Receptor sigma
Los receptores sigma son sitios de unión únicos que, a diferencia de los GPCR tradicionales, no encajan en las categorías clásicas de proteínas receptoras. Están involucrados en la modulación de los sistemas de neurotransmisores y se han implicado en varios trastornos neurológicos y psiquiátricos. Los receptores sigma también están asociados con la supervivencia celular, y sus ligandos se están explorando para aplicaciones terapéuticas en neuroprotección, cáncer y manejo del dolor. En CymitQuimica, ofrecemos una selección de moduladores de receptores sigma de alta calidad para apoyar su investigación en neurociencia, oncología y biología de receptores.
Productos de "Receptor sigma"
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Glycerol phenylbutyrate
CAS:Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).Fórmula:C33H38O6Pureza:99.00% - 99.74%Forma y color:SolidPeso molecular:530.65AF-710B
CAS:AF710B is an enantiomer of AF710. AF-710B is also a sigma and M1 muscarinic receptors agonist.Fórmula:C20H27N3OSPureza:98.62% - 99.89%Forma y color:SolidPeso molecular:357.51KSK67
CAS:KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with KiFórmula:C22H27N3O2Pureza:99.11%Forma y color:SoildPeso molecular:365.47PD 144418 oxalate
CAS:PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.Fórmula:C20H24N2O5Pureza:99.08%Forma y color:SolidPeso molecular:372.42Siramesine
CAS:Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potentFórmula:C30H31FN2OPureza:98%Forma y color:SolidPeso molecular:454.58σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.Fórmula:C22H28N2O2Forma y color:SolidPeso molecular:352.47S1R agonist 1 hydrochloride
CAS:S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFórmula:C20H26ClNOPureza:98%Forma y color:SolidPeso molecular:331.88S1R agonist 2 hydrochloride
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.Fórmula:C21H28ClNOPureza:98%Forma y color:SolidPeso molecular:345.91BMY-14802
CAS:BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.Fórmula:C18H22F2N4OPureza:98.93%Forma y color:SoildPeso molecular:348.39Ref: TM-T67739
1mg40,00€5mg88,00€10mg137,00€25mg264,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)87,00€Sigma-1 receptor antagonist 6
CAS:Sigma-1 receptor antagonist 6 (Compound 12), a σ1R antagonist, demonstrates significant antiallodynic effects by targeting the Sigma-1 receptor (σ1R). This compound is effective in animal models for neuropathic pain, particularly for reducing mechanical allodynia caused by paclitaxel.Fórmula:C32H34N6Forma y color:SolidPeso molecular:502.65Sigma-1 receptor antagonist 5
Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative, exhibits analgesic properties through its antagonistic action on sigma receptorsFórmula:C26H27N3OPureza:98%Forma y color:SolidPeso molecular:397.51Cutamesine dihydrochloride
CAS:Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.Fórmula:C23H32N2O2·2HClPureza:98.83% - 99%Forma y color:SolidPeso molecular:441.43Ref: TM-T3597
2mg38,00€5mg55,00€10mg96,00€25mg178,00€50mg281,00€100mg445,00€200mg640,00€1mL*10mM (DMSO)60,00€σ1 Receptor antagonist-1
CAS:σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.Fórmula:C21H23NOSPureza:99.80%Forma y color:SolidPeso molecular:337.48Ref: TM-T9244
2mg38,00€5mg55,00€10mg88,00€25mg170,00€50mg269,00€100mg391,00€200mg562,00€1mL*10mM (DMSO)59,00€OPC-14523 hydrochloride
CAS:OPC-14523 hydrochloride, an oral sigma/5-HT1A agonist, shows potent antidepressant activity with strong receptor affinity.Fórmula:C23H29Cl2N3O2Pureza:99.70%Forma y color:SolidPeso molecular:450.4AD186
AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.Fórmula:C22H28N2Pureza:98%Forma y color:SolidPeso molecular:320.47Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFórmula:C30H32ClFN2OPureza:100% - 99.75%Forma y color:SolidPeso molecular:491.04Ref: TM-T1885
1mg60,00€2mg88,00€5mg111,00€10mg173,00€25mg354,00€50mg528,00€100mg743,00€1mL*10mM (DMSO)120,00€Roluperidone
CAS:Roluperidone (CYR-101) is a novel cyclic amide derivative.Fórmula:C22H23FN2O2Pureza:96.46% - 97.77%Forma y color:SolidPeso molecular:366.43NE-100 hydrochloride
CAS:NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.Fórmula:C23H34ClNO2Pureza:98.85%Forma y color:SolidPeso molecular:391.98Ref: TM-T20797
1mg46,00€2mg57,00€5mg92,00€10mg137,00€25mg221,00€50mg329,00€100mg490,00€200mg700,00€500mg1.035,00€4-PPBP maleate
CAS:4-PPBP maleate: potent σ1 agonist, selective NR1a/2B NMDA antagonist, neuroprotective.Fórmula:C25H31NO4Pureza:99.54%Forma y color:SolidPeso molecular:409.52Ref: TM-T22513
5mg48,00€10mg74,00€25mg135,00€50mg210,00€100mg313,00€200mg442,00€1mL*10mM (DMSO)56,00€Blarcamesine hydrochloride
CAS:Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Fórmula:C19H24ClNOPureza:98.62% - 99.57%Forma y color:SolidPeso molecular:317.85Ref: TM-T4111
1mg46,00€2mg59,00€5mg93,00€10mg139,00€25mg255,00€50mg457,00€100mg655,00€500mg1.406,00€1mL*10mM (DMSO)97,00€
