Antibacteriano

Rufloxacin HCl (MF-934 HCl): a fluoroquinolone that inhibits topoisomerase and B-cell differentiation.

Pymetrozine (CGA 215944) is a Homoptera feeding inhibitor that effectively prevents transmission of the cauliflower mosaic caulimovirus by the aphid species

IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux, used in atherosclerosis research.

Ftaxilide (Histanorm) has antibacterial property, used as antiseptic.

Amikacin hydrate (BAY 41-6551 hydrate) is an aminoglycoside antibiotic with bacteriostatic properties.

Biapenem (CLI 86815), a carbapenem antibiotic, has broad antibacterial effects, stable kidney enzyme resistance, and low neurotoxicity.

N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders.

Robinetin (3,3',4',5',7-Pentahydroxyflavone) has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with

Applications 9-(2,5-d|Dioxo-L-3-amino-1-pyrrolidineacetic acid)-10-deglycine Daptomycin is a stereoisomer of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial. References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

Stability Light Sensitive, Temperature Sensitive Applications Labelled Lymecycline. A semi-synthetic antibiotic related to Tetracycline (T291400). Antibacterial. References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004),

Applications Ceftiofur Sodium is a cephalosporin based antibacterial compound. References Heinrich, K. et al: Food Addit. Contam. A., 30, 1733 (2013); Harlow, B. et al.: Veter. Microbiol., 166, 225 (2013);

Cefazolin sodium, a beta-lactam antibiotic, targets PBPs to disrupt bacterial cell wall synthesis, causing cell lysis.

Applications Labelled Isoniazid. Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic). References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)

Sulfamoxole (Sulfamoxol) is an antibacterial belonging to sulfonamide.

PNU-176798 is an agent with antimicrobial.

Walrycin B is a new-type antibacterial compound targeting the WalR response regulator.

Ribocil-C is a highly selective inhibitor of bacterial riboflavin riboswitches.

Applications Cefotiam Dihydrochloride-13C, 15N2 is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations. References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)

Cefoperazone (Medocef) inactivates PBPs, disrupting bacterial cell wall synthesis and division; inhibits rMrp2 [3H]E217βG uptake (IC50: 199 μM).

Difloxacin hydrochloride (Difloxacin HCl) is a fluoroquinolone antibiotic, is a broad-spectrum antibacterial drug.