Antibacteriano

TBT1 is a first-gen MsbA ATPase activator and LPS transport blocker in Acinetobacter, EC50 at 13 μM.

Impurity Cefalotin EP Impurity D Applications Deacetylcephalothin Lactone (Cefalotin EP Impurity D) is an impurity in the synthesis of Cefalonium (C236800), a first-generation cephalosporin antibiotic used as a long-acting intramammary cerate for infusion of dairy cows. References Endo, T.: Kach. Kokin. Kenk., 12, 8 (1991); Berry, E.A. et al.: J. Dairy Sci., 90, 760 (2007); Bradley, A.J. et al.: J. Dairy Sci., 93, 1566 (2010); Shibata, K., et al.: J. Antibiot., 50, 135 (1997);

Thiamphenicol (Dextrosulphenidol) is a methylsulfonyl analog of chloramphenicol. It is an antibiotic and immunosuppressive agent.

Sulfamethoxazole (STX 608), a sulfonamide antimicrobial, inhibits Cytochrome P450 2C9.

Stability Hygroscopic Applications Ribostamycin is a broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. It is used in pharmacokinetic and nephrotoxicity studies. References Zhou, S., et al.: Clinical Pharmacokinetics, 22, 144 (1992); Kitasato, I., et al.: Drugs Under Experimental and Clinical Research, 15, 273 (1989)

Applications Antibacterial. References Bourguignon, G.J., et al.: Antimicrob. Agents Chemother., 4, 479 (1973), Grubb, P.E., et al.: Anal. Profiles Drug Subs., 8, 371 (1979), Wright, H.T., et al.: Science, 213, 455 (1981),

Myristoyl glutamic acid (N-Myristoyl-L-glutamic acid) is a myristoyl glutamic acid, a surfactant that can be added to evolved make-up with foaming and partial

(3R,4R)-A2-32-01 is the (R,R)-enantiomer of A2-32-01 and has potential antibacterial activity.

2,6-Dimethoxyquinone, slightly soluble and weakly basic, is found in Rauvolfia vomitoria, Tibouchina pulchra, and wheat.

Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.

Effusanin A: antibacterial, damages DNA, inhibits DU145 cells at 3.16 μM and LoVo cells at 3.02 μM.

Chalcone (Cinnamophenone) is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as

Contezolid (MRX-I) is an antibiotic with bactericidal activity and can be used to study tuberculosis.

Chloroxine (Capitrol) is a quinoline derivative with antibacterial activity. Topical administration of chloroxine diminishes mitotic activity in the epidermis.

Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit.

Stability Hygroscopic Applications Neomycin C Hexaacetate is an aminoglycoside antibiotic found in many topical medications. Neomycin has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. References Umezawa, S., et al.: Bull. Chem. Soc. Jpm., 53, 3259 (1980); The Journal of antibiotics, NO. 2. 189 (1977);

Impurity Cefuroxime Sodium EP Impurity E Applications Desethyl Acetate (E)-Cefuroxime Axetil (Cefuroxime Sodium EP Impurity E) is a product from the photoisomerization of Cefuroxime Axetil (C248065), which is s widely used to treat respiratory tract infections. Antibacterial. References Fabre, H., et. al.: J. Pharm. Sci., 83, 553 (1994); Nguyen, N., et al.: Pharm. Res., 8, 893 (1991); Stoeckel, K., et al.: Antimicrob. Agents Chemother., 42, 2602 (1998); Scott, L., et al.: Drugs, 61, 1455 (2001); Bulitta, J. B., et al.: Antimicrob. Agents Chemother., 53, 3462 (2009)

WAY-329764 is an antibacterial agent.

4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label, it displays good activity against B. subtilis.

Applications Vaborbactam is a non-β-lactam β-lactamase inhibitor. While not effective as an antibiotic by itself, it restores potency to existing antibiotics by inhibiting the beta-lactamase enzymes that would otherwise degrade them. When combined with an appropriate antibiotic it can be used for the treatment of gram-negative bacterial. References Hecker, S.J., et al.: Journal of Medicinal Chemistry, 58, 3682 (2015);