Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
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Productos de "Señalización PI3K / Akt / mTOR"
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Anti-EGFR Antibody (3B845)
Anti-EGFR Antibody (3B845) is an antibody targeting EGFR. Anti-EGFR Antibody (3B845) can be used in ELISA, WB, IHC.Forma y color:Odour LiquidPetosemtamab (FUT8-KO)
Petosemtamab (FUT8-KO) is a variant of Petosemtamab with the fucosyltransferase 8 gene (FUT8) knocked out. Petosemtamab is a monoclonal antibody (mAb) targeting EGFR (with a Kd of 0.22 nM) and LGR5 (with a Kd of 0.86 nM). This antibody disrupts EGFR signaling and causes receptor degradation in LGR5+ cancer cells. It is applicable in research on solid tumors such as head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer (CRC).Forma y color:Odour LiquidMELK-8a hydrochloride
CAS:MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM).Fórmula:C25H33ClN6OPureza:99.87%Forma y color:SolidPeso molecular:469.02Ref: TM-T11996
2mg35,00€5mg52,00€10mg85,00€25mg156,00€50mg239,00€100mg353,00€200mg492,00€1mL*10mM (DMSO)55,00€Allitinib tosylate
CAS:Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.Fórmula:C31H26ClFN4O5SPureza:98.46% - 98.68%Forma y color:SolidPeso molecular:621.08Kaempferol 3-neohesperidoside
CAS:Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid compound, demonstrates an insulinomimetic effect on the rat soleus muscle.Fórmula:C27H30O15Pureza:98.34%Forma y color:SolidPeso molecular:594.52Ref: TM-TN1819
1mg62,00€5mg127,00€10mg187,00€25mg315,00€50mg472,00€100mg658,00€1mL*10mM (DMSO)166,00€PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Fórmula:C20H15Cl2N5O3Pureza:98%Forma y color:SolidPeso molecular:444.27ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Fórmula:C20H25N3O3Pureza:98%Forma y color:SolidPeso molecular:355.43PI3K-IN-38
CAS:PI3K-IN-38: oral PI3K inhibitor, IC50 of 0.541 µM, anticancer, anti-inflammatory, halts tumors in vivo.Fórmula:C20H24N6O2Pureza:99.74%Forma y color:SolidPeso molecular:380.44Rheb inhibitor NR1
CAS:Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Fórmula:C25H19BrCl2N2O3SPureza:99.72%Forma y color:SolidPeso molecular:578.3Ref: TM-T16741
1mg92,00€5mg188,00€10mg311,00€25mg628,00€50mg945,00€100mg1.596,00€1mL*10mM (DMSO)47,00€GSK3a-IN-38
CAS:GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.Fórmula:C18H20N4OPureza:99.75%Forma y color:SoildPeso molecular:308.38Cisapride hydrate
CAS:Cisapride acts directly as a selective agonist of serotonin 5-HT4 receptor with IC50 value of 0.483 μM. And It also acts indirectly as a parasympathomimetic.Fórmula:C23H31ClFN3O5Pureza:98%Forma y color:SolidPeso molecular:483.96Naquotinib
CAS:Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFRFórmula:C30H42N8O3Pureza:97.49%Forma y color:SolidPeso molecular:562.71EGFR/CDK2-IN-4
EGFR/CDK2-IN-4 (compound 4c) is a dual inhibitor targeting EGFR and CDK-2, demonstrating IC50 values of 89.6 nM for EGFR and 165.4 nM for CDK-2.Fórmula:C24H16N6OS2Pureza:98%Forma y color:SolidPeso molecular:468.55Acalisib
CAS:Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.Fórmula:C21H16FN7OPureza:98.99% - ≥95%Forma y color:SolidPeso molecular:401.4HG-9-91-01
CAS:HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 andFórmula:C32H37N7O3Pureza:96.86% - 99.64%Forma y color:SolidPeso molecular:567.68Ref: TM-T4599
1mg84,00€2mg96,00€5mg160,00€10mg274,00€25mg459,00€50mg658,00€100mg939,00€1mL*10mM (DMSO)187,00€H-9 dihydrochloride
CAS:H-9 dihydrochloride: Strong PKA inhibitor, curbs 5-HT response and EGF signaling, affects pharyngeal function.Fórmula:C11H15Cl2N3O2SPureza:96.57%Forma y color:SolidPeso molecular:324.23AZD-8835
CAS:AZD-8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).Fórmula:C22H31N9O3Pureza:98.22% - 98.49%Forma y color:SolidPeso molecular:469.544-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Fórmula:C8H6BrClOPureza:99.56%Forma y color:White To Beige SolidPeso molecular:233.49FD2056
CAS:FD2056 is a potent, orally active PI3K inhibitor, with IC50 values of 0.30, 0.80, 1.10, and 0.42 nM against PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively.Fórmula:C23H17ClN6O2SPureza:98%Forma y color:SolidPeso molecular:476.94MSC2360844
CAS:MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).Fórmula:C26H27FN4O5SPureza:100% - 99.32%Forma y color:SolidPeso molecular:526.58Ref: TM-T12115
1mg52,00€5mg116,00€10mg182,00€25mg354,00€50mg568,00€100mg900,00€200mg1.206,00€1mL*10mM (DMSO)135,00€
