Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
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Productos de "Señalización PI3K / Akt / mTOR"
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ASP4132
CAS:ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Fórmula:C46H51F3N6O8S2Pureza:98.34%Forma y color:SolidPeso molecular:937.06Ref: TM-T8432
1mg67,00€2mg96,00€5mg131,00€10mg197,00€25mg358,00€50mg535,00€100mg753,00€1mL*10mM (DMSO)205,00€ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.Fórmula:C18H14N4OSPureza:98.53%Forma y color:SolidPeso molecular:334.39PH14
PH14, a dual PI3K/HDAC inhibitor, demonstrates potent inhibition with IC50 values of 20.3 nM for PI3Kα and 24.5 nM for HDAC3.Pureza:98%Forma y color:Odour SolidAntiproliferative agent-34
CAS:Antiproliferative Agent-34 (Compound A14), a multitarget kinase inhibitor, demonstrates IC50 values of 177 nM for EGFR L858R/T790M and 1567 nM for EGFR WT.Fórmula:C27H27N7O5Pureza:98%Forma y color:SolidPeso molecular:529.55YKL-06-062
CAS:YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor that inhibits SIK1, SIK2 and SIK3 with IC50s of 2.12 nM, 1.40 nM and 2.86 nM.Fórmula:C31H39N7OPureza:99.95%Forma y color:SolidPeso molecular:525.69S6K1-IN-DG2
CAS:S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.Fórmula:C16H17BrN6OPureza:99.25%Forma y color:SolidPeso molecular:389.25ARN-3236
CAS:ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nMFórmula:C19H16N2O2SPureza:99.57% - 99.7%Forma y color:SolidPeso molecular:336.41Ref: TM-T5993
1mg60,00€2mg86,00€5mg124,00€10mg182,00€25mg343,00€50mg427,00€100mg658,00€200mg938,00€500mg1.388,00€1mL*10mM (DMSO)150,00€PI3K/VEGFR2-IN-1
CAS:PI3K/VEGFR2-IN-1 is a potent dual inhibitor targeting both PI3K and VEGFR2 with IC50 values of 2.21 μM for PI3K and 68 μM for VEGFR2, respectively.Fórmula:C17H14ClN3OSPureza:98%Forma y color:SolidPeso molecular:343.83KU-57788
CAS:NU7441 (KU-57788 (NU7441)) is a highly effective and specific DNA-PK inhibitor (IC50: 14 nM).Fórmula:C25H19NO3SPureza:100% - 99.87%Forma y color:SolidPeso molecular:413.49PQR530
CAS:PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Fórmula:C18H23F2N7O2Pureza:99.50%Forma y color:SolidPeso molecular:407.42Duvelisib (R enantiomer)
CAS:Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.Fórmula:C22H17ClN6OPureza:98%Forma y color:SolidPeso molecular:416.86YU238259
CAS:YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.Fórmula:C22H22ClN3O4SPureza:99.12% - 99.43%Forma y color:SolidPeso molecular:459.95Ref: TM-T4339
1mg48,00€2mg63,00€5mg87,00€10mg153,00€25mg305,00€50mg543,00€100mg780,00€500mg1.605,00€1mL*10mM (DMSO)87,00€Pred17
Pred17 is an effective EGFR inhibitor with potential applications in lung cancer research.Fórmula:C27H22BN3OForma y color:SolidPeso molecular:415.29JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Fórmula:C17H14Cl2FN3OSPureza:98.87%Forma y color:SolidPeso molecular:398.28Ref: TM-T11728
1mg95,00€5mg202,00€10mg344,00€25mg630,00€50mg945,00€100mg1.264,00€1mL*10mM (DMSO)224,00€OTSSP167
CAS:OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.Fórmula:C25H28Cl2N4O2Pureza:98.22% - 99.47%Forma y color:SolidPeso molecular:487.42Ref: TM-T1759
1mg40,00€2mg51,00€5mg88,00€10mg119,00€25mg187,00€50mg283,00€100mg432,00€500mg938,00€1mL*10mM (DMSO)96,00€Icotinib Hydrochloride
CAS:Icotinib Hydrochloride, an oral EGFR inhibitor (BPI-2009H), may halt cancer growth by blocking EGFR signaling.Fórmula:C22H22ClN3O4Pureza:99.77%Forma y color:SolidPeso molecular:427.88TAS6417
CAS:Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.Fórmula:C23H20N6OPureza:99.71%Forma y color:SolidPeso molecular:396.44Ref: TM-T16996
1mg87,00€2mg124,00€5mg188,00€10mg311,00€25mg630,00€50mg1.008,00€100mg1.549,00€500mg3.117,00€1mL*10mM (DMSO)215,00€ALK/EGFR-IN-1
CAS:ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.Fórmula:C27H34ClN7O3SPureza:98%Forma y color:SolidPeso molecular:572.12R547
CAS:R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.Fórmula:C18H21F2N5O4SPureza:90% - 99.84%Forma y color:SolidPeso molecular:441.45Ref: TM-T6312
1mg49,00€2mg72,00€5mg107,00€10mg156,00€25mg283,00€50mg542,00€100mg778,00€500mg1.605,00€1mL*10mM (DMSO)127,00€SYR127063
CAS:SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.Fórmula:C23H20ClF3N4O3Pureza:98.57%Forma y color:SolidPeso molecular:492.88
