Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
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Productos de "Señalización PI3K / Akt / mTOR"
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PDK1-IN-RS2
CAS:PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).Fórmula:C15H9ClN2O2S3Pureza:98%Forma y color:SolidPeso molecular:380.89KI8751
CAS:KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.Fórmula:C24H18F3N3O4Pureza:99.22% - 99.9%Forma y color:SolidPeso molecular:469.41Ref: TM-T2446
2mg37,00€5mg52,00€10mg86,00€25mg156,00€50mg294,00€100mg472,00€200mg670,00€1mL*10mM (DMSO)56,00€EGFR-IN-11
CAS:EGFR-IN-11 selectively blocks EGFR-tyrosine kinase and promotes apoptosis; targets EGFRL858R/T790M/C797S, IC50=18 nM; halts cell cycle at G0/G1.Fórmula:C29H35N9O2SPureza:99.37%Forma y color:SolidPeso molecular:573.71Ref: TM-T11158
1mg51,00€5mg116,00€10mg192,00€25mg304,00€50mg420,00€100mg560,00€1mL*10mM (DMSO)147,00€BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.Fórmula:C22H25N3OPureza:99.75%Forma y color:SolidPeso molecular:347.45Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Fórmula:C29H26ClFN4O4S·2C7H8O3SPureza:99.41%Forma y color:Yellow SolidPeso molecular:925.46CP-380736
CAS:CP-380736 (PF-00520893) inhibits EGFR, a kinase key in cancer-signaling pathways like MAPK, JNK, and Akt.Fórmula:C14H18N2O5Pureza:99.68%Forma y color:White To Off-White SolidPeso molecular:294.3Lifirafenib
CAS:Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinantFórmula:C25H17F3N4O3Pureza:98% - 98.25%Forma y color:SolidPeso molecular:478.42Ref: TM-T22272
1mg35,00€5mg69,00€10mg97,00€25mg190,00€50mgA consultar100mgA consultar1mL*10mM (DMSO)89,00€PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Fórmula:C18H18Cl2N6OPureza:96.78%Forma y color:SolidPeso molecular:405.28Mutant EGFR inhibitor
CAS:Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.Fórmula:C27H30ClN7O2Pureza:96.21% - 98%Forma y color:SolidPeso molecular:520.03Ref: TM-T2705
1mg37,00€2mg52,00€5mg80,00€10mg97,00€25mg168,00€50mg264,00€100mg379,00€500mgA consultar1mL*10mM (DMSO)104,00€CZ415
CAS:CZ415 is a potent and highly selective mTOR inhibitor.Fórmula:C22H29N5O4SPureza:97.54% - 98.36%Forma y color:SolidPeso molecular:459.56Ref: TM-T3514
1mg42,00€2mg51,00€5mg74,00€10mg110,00€25mg224,00€50mg338,00€100mg472,00€200mg652,00€1mL*10mM (DMSO)75,00€TGX-115
CAS:TGX-115 inhibits PI 3-K p110β (IC50=0.13μM) & p110δ (IC50=0.63μM), treats various cardiovascular diseases.Fórmula:C20H20N2O3Pureza:99.2%Forma y color:SolidPeso molecular:336.38Ref: TM-T24873
1mg200,00€5mg472,00€10mg645,00€25mg905,00€50mg1.121,00€100mg1.425,00€200mg1.863,00€1mL*10mM (DMSO)389,00€Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Forma y color:SolidPeso molecular:406.48AMPK activator 13
AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygenPureza:98%Forma y color:Odour SolidDNA-PK-IN-15
CAS:DNA-PK-IN-15 (compound 6) acts as an inhibitor of DNA-PK, exhibiting an IC50 value of 0.08 nM.Fórmula:C23H23N9OForma y color:SolidPeso molecular:441.49Tarloxotinib bromide
CAS:Tarloxotinib bromide (TH-4000) is an irreversible inhibitor of EGFR/HER2.Fórmula:C24H24Br2ClN9O3Pureza:97.15%Forma y color:SolidPeso molecular:681.77Ref: TM-T13088
1mg140,00€5mg283,00€10mg432,00€25mg707,00€50mg938,00€100mg1.311,00€1mL*10mM (DMSO)437,00€Tyrosine kinase-IN-7
CAS:Tyrosine kinase-IN-7 is a potent inhibitor of the tyrosine kinase EGFR, inhibiting EGFR(WT) and EGFR(T790M) and showing anti-cancer and anti-tumor activity.Fórmula:C16H15N3OSPureza:99.93%Forma y color:SolidPeso molecular:297.38HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Fórmula:C13H17ClF3N5OPureza:98%Forma y color:SolidPeso molecular:351.76Vacuolin-1
CAS:Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane.Fórmula:C26H24IN7OPureza:97.20% - 98.45%Forma y color:SolidPeso molecular:577.42Os30
Os30 is a potent fourth-generation EGFR inhibitor, specifically targeting the EGFRC797S-TK mutation with IC50 values of 18 nM for EGFRDel19/T790M/C797S TK andPureza:98%Forma y color:Odour SolidTrastuzumab
CAS:Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Pureza:98% - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Forma y color:LiquidPeso molecular:Approximately 145.53 kDa
