mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Productos de "mTOR"
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Torin 2
CAS:Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.Fórmula:C24H15F3N4OPureza:98.31% - 99.32%Forma y color:SolidPeso molecular:432.4GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:504.63Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Fórmula:C44H70O16Pureza:98% - 99.5%Forma y color:SolidPeso molecular:855.02PQR620
CAS:PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.Fórmula:C21H25F2N7O2Pureza:97.61%Forma y color:SolidPeso molecular:445.47Ref: TM-T5472
1mg64,00€5mg150,00€10mg210,00€25mg354,00€50mg505,00€100mg677,00€200mg914,00€1mL*10mM (DMSO)145,00€Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Fórmula:C23H30N8O3SPureza:98.28% - 99.52%Forma y color:SolidPeso molecular:498.6WYE-132
CAS:WYE-125132: potent mTOR inhibitor, IC50 0.19 nM, selective over PI3Ks/hSMG1/ATR.Fórmula:C27H33N7O4Pureza:99.16%Forma y color:SolidPeso molecular:519.6Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Fórmula:C21H27ClN2S2Pureza:99.55% - 99.55%Forma y color:White To Off-White SolidPeso molecular:407.04NV-5138
CAS:NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.Fórmula:C7H13F2NO2Pureza:98% - ≥98%Forma y color:SolidPeso molecular:181.18OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Fórmula:C21H22N6O3Pureza:97.42%Forma y color:SolidPeso molecular:406.44Ref: TM-T6319
1mg42,00€2mg52,00€5mg86,00€10mg138,00€25mg248,00€50mg389,00€100mg567,00€1mL*10mM (DMSO)88,00€Onatasertib
CAS:Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.Fórmula:C21H27N5O3Pureza:99.14% - 99.91%Forma y color:SolidPeso molecular:397.47MHY-1685
CAS:MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.Fórmula:C11H8N2O4Pureza:98.44%Forma y color:SolidPeso molecular:232.194-FPBUA
CAS:4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.Fórmula:C31H23FO7Forma y color:SolidPeso molecular:526.51mTOR inhibitor-11
CAS:mTOR inhibitor-11 (Compound 9) is a brain-penetrant compound capable of inhibiting mTOR with an IC50 of 21 nM for pS6.Fórmula:C21H26N6O2Pureza:98%Forma y color:SolidPeso molecular:394.47GDC-0349
CAS:GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.Fórmula:C24H32N6O3Pureza:96.00% - 98.98%Forma y color:SolidPeso molecular:452.55Ref: TM-T6510
2mg39,00€5mg66,00€10mg107,00€25mg215,00€50mg324,00€100mg462,00€500mgA consultar1mL*10mM (DMSO)70,00€mTOR inhibitor-1
CAS:C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Fórmula:C16H15BrN2O3Pureza:99.43%Forma y color:SolidPeso molecular:363.21Anti-Phospho-MTOR (Ser2481) Antibody (4R8)
Anti-Phospho-MTOR (Ser2481) Antibody (4R8) is an antibody targeting Phospho-MTOR (Ser2481). Anti-Phospho-MTOR (Ser2481) Antibody (4R8) can be used in ELISA, WB, IF.Forma y color:Odour LiquidEverolimus
CAS:Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.Fórmula:C53H83NO14Pureza:97.76% - 99.52%Forma y color:Off-White To Light Yellow PowdPeso molecular:958.22Ref: TM-T1784
5mg44,00€10mg55,00€25mg82,00€50mg96,00€100mg120,00€200mg177,00€500mg298,00€1mL*10mM (DMSO)55,00€L-Leucine
CAS:L-Leucine is an essential amino acid vital for protein synthesis, metabolism, muscle and bone repair, blood sugar control, and wound healing.Fórmula:C6H13NO2Pureza:100%Forma y color:White Solid CrystallinePeso molecular:131.17Temsirolimus
CAS:Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.Fórmula:C56H87NO16Pureza:100% - 99.64%Forma y color:White Crystalline PowderPeso molecular:1030.29Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66%Forma y color:SolidPeso molecular:332.39
