mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Productos de "mTOR"
Ordenar por
MTI-31
CAS:MTI-31 (LXI-15029) is a potent oral mTORC1/2 inhibitor with a Kd of 0.20 nM, >5,000-fold selectivity, and an IC50 of 39 nM.Fórmula:C26H30N6O3Pureza:99.76%Forma y color:SolidPeso molecular:474.55Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14TMBIM6 antagonist-1
CAS:TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitorFórmula:C15H12N2O3Pureza:99.26%Forma y color:SolidPeso molecular:268.27Ref: TM-T8649
1mg93,00€2mg120,00€5mg187,00€10mg315,00€25mg567,00€50mg810,00€100mg1.111,00€500mg2.232,00€1mL*10mM (DMSO)202,00€Rapamycin
CAS:Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.Fórmula:C51H79NO13Pureza:97.08% - 99.03%Forma y color:Yellow SolidPeso molecular:914.17Ref: TM-T1537
1g283,00€10mg35,00€25mg48,00€50mg52,00€100mg69,00€200mg106,00€500mg188,00€1mL*10mM (DMSO)50,00€CC214-1
CAS:CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.Fórmula:C20H21N7O2Pureza:97.87%Forma y color:SolidPeso molecular:391.43WYE-354
CAS:WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).Fórmula:C24H29N7O5Pureza:97.86% - 99.61%Forma y color:SolidPeso molecular:495.53Gedatolisib
CAS:Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFórmula:C32H41N9O4Pureza:98% - 99.48%Forma y color:SolidPeso molecular:615.73Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Forma y color:SolidPeso molecular:505.5FT-1518
CAS:FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.Fórmula:C20H26N8OPureza:98.34% - 98.80%Forma y color:SolidPeso molecular:394.47CC-115
CAS:CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).Fórmula:C16H16N8OPureza:86.79% - 99.22%Forma y color:SolidPeso molecular:336.35Voxtalisib
CAS:Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.Fórmula:C13H14N6OPureza:98.01% - 99.36%Forma y color:SolidPeso molecular:270.29Ref: TM-T7014
1mg38,00€2mg49,00€5mg79,00€10mg124,00€25mg240,00€50mg384,00€100mg560,00€1mL*10mM (DMSO)79,00€NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Fórmula:C29H27F2N5O5S2Pureza:99.58%Forma y color:SolidPeso molecular:627.68Ref: TM-T16355
2mg42,00€5mg64,00€10mg93,00€25mg168,00€50mg245,00€100mg375,00€200mg533,00€1mL*10mM (DMSO)88,00€Cyclovirobuxine D
CAS:Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.Fórmula:C26H46N2OPureza:97.78% - 98%Forma y color:SolidPeso molecular:402.66Rheb inhibitor NR1
CAS:Rheb inhibitor NR1 is a Rheb inhibitor and selective mTORC1 inhibitor that promotes phosphorylation of S473pAKT.Fórmula:C25H19BrCl2N2O3SPureza:99.72%Forma y color:SolidPeso molecular:578.3Ref: TM-T16741
1mg92,00€5mg188,00€10mg311,00€25mg628,00€50mg945,00€100mg1.596,00€1mL*10mM (DMSO)47,00€JR-AB2-011
CAS:JR-AB2-011: selective mTORC2 inhibitor, IC50 = 0.36μM, blocks Rictor-mTOR, Ki = 0.19μM, cytotoxic in glioblastoma.Fórmula:C17H14Cl2FN3OSPureza:98.87%Forma y color:SolidPeso molecular:398.28Ref: TM-T11728
1mg95,00€5mg202,00€10mg344,00€25mg630,00€50mg945,00€100mg1.264,00€1mL*10mM (DMSO)224,00€Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Fórmula:C25H30N6O3Pureza:97.08% - 99.06%Forma y color:SolidPeso molecular:462.54Ref: TM-T1961
1mg37,00€5mg74,00€10mg117,00€25mg173,00€50mg236,00€100mg378,00€200mg558,00€1mL*10mM (DMSO)84,00€Dactolisib
CAS:Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).Fórmula:C30H23N5OPureza:97.64% - 99.85%Forma y color:SolidPeso molecular:469.54Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Forma y color:SolidPeso molecular:406.48Insecticidal agent 364
CAS:Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.Fórmula:C23H18N4O3SPureza:98.24%Forma y color:SolidPeso molecular:430.48Hederacolchiside A1
CAS:Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Fórmula:C47H76O16Pureza:99.54% - 99.92%Forma y color:SolidPeso molecular:897.1Ref: TM-T2P2806
1mg48,00€5mg120,00€10mg170,00€25mg283,00€50mg430,00€100mg620,00€1mL*10mM (DMSO)170,00€
