mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Productos de "mTOR"
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BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:100% - 98.40%Forma y color:SolidPeso molecular:534.53Ref: TM-T6072L
1mg52,00€5mg114,00€10mg187,00€25mg411,00€50mg607,00€100mg847,00€1mL*10mM (DMSO)156,00€Corynoxine
CAS:Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.Fórmula:C22H28N2O4Pureza:96.83% - 99.93%Forma y color:SolidPeso molecular:384.47BGT226 maleate
CAS:BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .Fórmula:C28H25F3N6O2·C4H4O4Pureza:97.75% - 98.78%Forma y color:SolidPeso molecular:650.6Ref: TM-T6072
1mg38,00€5mg77,00€10mg114,00€25mg244,00€50mg359,00€100mg512,00€200mg702,00€1mL*10mM (DMSO)99,00€GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Fórmula:C19H22N6O3SPureza:98.42% - 99.42%Forma y color:SolidPeso molecular:414.48Ref: TM-T6845
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg210,00€50mg349,00€100mg434,00€200mg635,00€1mL*10mM (DMSO)92,00€MT 63-78
CAS:MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).Fórmula:C21H14N2O2Pureza:97.11%Forma y color:SolidPeso molecular:326.35PF-04979064
CAS:PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).Fórmula:C24H26N6O3Pureza:98.04% - ≥98%Forma y color:SolidPeso molecular:446.5GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFórmula:C17H20N6O2SPureza:98%Forma y color:SolidPeso molecular:372.44mTOR inhibitor-14
mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1Pureza:98%Forma y color:Odour SolidAutogramin-1
CAS:Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.Fórmula:C23H27N5O5SPureza:97.22% - 98.76%Forma y color:SolidPeso molecular:485.56PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Forma y color:SolidPeso molecular:425.48P-2281
CAS:P-2281 is an mTOR inhibitor with anticancer and anti-inflammatory properties.P-2281 inhibits dextran sulfate sodium (DSS)-induced colitis by suppressing T-cellFórmula:C9H8ClN3OPureza:99.95%Forma y color:SolidPeso molecular:209.63MHY1485
CAS:MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.Fórmula:C17H21N7O4Pureza:100% - 99.6%Forma y color:SolidPeso molecular:387.39Lupiwighteone
CAS:Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.Fórmula:C20H18O5Pureza:99.20%Forma y color:SolidPeso molecular:338.35Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Fórmula:C43H45BrCl2N3OPPureza:97.25% - 98.34%Forma y color:SolidPeso molecular:801.62S6K1-IN-DG2
CAS:S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.Fórmula:C16H17BrN6OPureza:99.25%Forma y color:SolidPeso molecular:389.25PQR530
CAS:PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Fórmula:C18H23F2N7O2Pureza:99.50%Forma y color:SolidPeso molecular:407.42AZD-8055
CAS:AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.Fórmula:C25H31N5O4Pureza:98% - 99.69%Forma y color:SolidPeso molecular:465.54mTOR inhibitor-3
CAS:mTOR inhibitor-3 is a selective mTOR inhibitor (Ki= 1.5 nM). mTOR inhibitor-3 inhibits mTORC1 and mTORC2 in cellular and in vivo experiments.Fórmula:C25H30N8O2Pureza:98.29% - 99%Forma y color:SolidPeso molecular:474.56Ref: TM-T12123
1mg60,00€5mg127,00€10mg180,00€25mg306,00€50mg464,00€100mg655,00€500mg1.359,00€1mL*10mM (DMSO)135,00€Rotundic acid
CAS:Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.Fórmula:C30H48O5Pureza:96.91% - 99.97%Forma y color:SolidPeso molecular:488.7CZ415
CAS:CZ415 is a potent and highly selective mTOR inhibitor.Fórmula:C22H29N5O4SPureza:97.54% - 98.36%Forma y color:SolidPeso molecular:459.56Ref: TM-T3514
1mg42,00€2mg51,00€5mg74,00€10mg110,00€25mg224,00€50mg338,00€100mg472,00€200mg652,00€1mL*10mM (DMSO)75,00€
