Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Productos de "Señalización citoesquelética"
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AZ82
CAS:AZ82 is an inhibitor of the kinesin-like protein KIFC1, which induces multipolar mitosis and apoptosis in prostate cancer cells.Fórmula:C28H31F3N4O3SPureza:99.31%Forma y color:SolidPeso molecular:560.63Kazinol B
CAS:Kazinol B is an inhibitor of nitric oxide (NO) production, an isopentenylated flavan with a dimethylpyran ring.Kazinol B improves insulin sensitivity byFórmula:C25H28O4Pureza:98%Forma y color:SolidPeso molecular:392.49Procyanidin A1
CAS:Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+.Fórmula:C30H24O12Pureza:99.52%Forma y color:SolidPeso molecular:576.5AKT Kinase Inhibitor HCl
AKT Kinase Inhibitor HCl is an Akt inhibitor with antitumor activity.Fórmula:C16H20ClN7O3Pureza:98.87%Forma y color:SoildPeso molecular:393.83Taurochenodeoxycholic Acid
CAS:Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Fórmula:C26H45NO6SPureza:99.69% - 99.86%Forma y color:SolidPeso molecular:499.7C16Y
CAS:C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Fórmula:C78H115N17O17Forma y color:SolidPeso molecular:1562.85Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Fórmula:C28H34O7Pureza:99.38% - 99.68%Forma y color:SolidPeso molecular:482.57Ref: TM-T21883
1mg393,00€5mg1.169,00€10mg1.596,00€25mg2.365,00€50mg3.192,00€100mg4.304,00€1mL*10mM (DMSO)1.283,00€Si306
CAS:Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).Fórmula:C25H26BrClN6OSForma y color:SolidPeso molecular:573.94Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Fórmula:C32H46O8Pureza:97.10% - 99.33%Forma y color:SolidPeso molecular:558.7Afuresertib
CAS:Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFórmula:C18H17Cl2FN4OSPureza:97.51% - 99.17%Forma y color:SolidPeso molecular:427.32Ref: TM-T1911
1mg39,00€2mg50,00€5mg79,00€10mg97,00€25mg170,00€50mg274,00€100mg477,00€500mg1.035,00€1mL*10mM (DMSO)79,00€Ζ-Stat
CAS:ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis inFórmula:C10H8O10S3Pureza:98.01%Forma y color:SolidPeso molecular:384.36FRAX1036
CAS:FRAX-1036 is a effective and selective PAK1 inhibitor.Fórmula:C28H32ClN7OPureza:97.66% - 99.95%Forma y color:SolidPeso molecular:518.05Ref: TM-T6839
1mg51,00€2mg69,00€5mg87,00€10mg119,00€25mg210,00€50mg354,00€100mg512,00€1mL*10mM (DMSO)97,00€JB002
CAS:JB002, a myosin II inhibitor, exhibits potent activity with an IC50 of ≤10 μM.Fórmula:C18H15NO3Pureza:99.02%Forma y color:SoildPeso molecular:293.32Ref: TM-T72023
1mg77,00€5mg169,00€10mg264,00€25mg535,00€50mg747,00€100mg1.035,00€500mg2.072,00€1mL*10mM (DMSO)180,00€Monomethyl lithospermate
CAS:Monomethyl lithospermate shows antiviral traits, aids ischemic stroke via PI5K/Akt, protects SHSY-3Y cells, and reduces oxidative stress in MCAO rats.Fórmula:C28H24O12Pureza:98%Forma y color:SolidPeso molecular:552.48CFI-402257
CAS:CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.Fórmula:C28H30N6O3Pureza:96.66% - 99.51%Forma y color:SolidPeso molecular:498.58HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFórmula:C23H40O5Pureza:98%Forma y color:SolidPeso molecular:396.56PS315
CAS:PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.Fórmula:C23H19ClO2Pureza:98%Forma y color:SolidPeso molecular:362.85PKN1/2-IN-1
CAS:PKN1/2-IN-1 is a potent and selective PKN2 inhibitor, membrane permeability and anticancer.Protein kinase N proteins (PKN) are effectors of Rho GTPases.Fórmula:C14H15N3OForma y color:SolidPeso molecular:241.29POSH-IN-2
CAS:POSH-IN-2 (MIDI) is a mitochondrial fission inhibitor and a DRP1 inhibitor that effectively prevents mitochondrial fragmentation caused by cellular stress and genetic mitochondrial damage. It covalently interacts with DRP1-C367 to target the interaction of DRP1 with multiple receptors.Fórmula:C22H16N2O2Forma y color:SolidPeso molecular:340.37BCR-ABL-IN-9
BCR-ABL-IN-9 (Compound B1) is an inhibitor of BCR-ABL that achieves sustained suppression through the formation of stable covalent bonds with the ABL kinase. It effectively inhibits the activity of ABL kinase (IC50 = 1.2 nM) and possesses anticancer activity.Fórmula:C22H20N4O3Forma y color:SolidPeso molecular:388.42KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.89%Forma y color:SolidPeso molecular:332.4TRAP1-IN-1
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90.Fórmula:C45H39F7N2O4P2Pureza:98%Forma y color:SolidPeso molecular:866.74Ifebemtinib FA
BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.Fórmula:C29H30F4N6O6Pureza:98.40% - 99.62%Forma y color:SolidPeso molecular:634.58HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Fórmula:C29H48O10Pureza:98%Forma y color:SolidPeso molecular:556.69KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Fórmula:C23H20ClFO4Forma y color:SolidPeso molecular:414.85KIF18A-IN-15
CAS:KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, both with an IC50 range of 0.01-0.1 μM. These compounds inhibit the viability of OVCAR-3 cells, with IC50 values of 0.01-0.1 μM for EX36-A and 0-0.01 μM for EX36-B. KIF18A-IN-15 is applicable in research on tumors, including colon, breast, and lung cancers.Fórmula:C25H33F3N6O5SForma y color:SolidPeso molecular:586.63CCT128930
CAS:'CCT128930, potent Akt2 inhibitor (IC50=6 nM), 28x more selective over PKA.'Fórmula:C18H20ClN5Pureza:99.07% - 99.18%Forma y color:SolidPeso molecular:341.84Ref: TM-T6303
2mg42,00€5mg65,00€10mg94,00€25mg170,00€50mg273,00€100mg409,00€200mg652,00€1mL*10mM (DMSO)71,00€BTB-1
CAS:BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.Fórmula:C12H8ClNO4SPureza:99.71%Forma y color:SolidPeso molecular:297.71Kif15-IN-2
CAS:Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.Fórmula:C20H20N6O4SPureza:98.17%Forma y color:SolidPeso molecular:440.48PKCε inhibitor peptide,myristoylated
Myristoylated PKCε inhibitor peptide (Myr-PKCε-) is a cell-permeable inhibitor consisting of a peptide linked to myristic acid that specifically inhibitsFórmula:C51H91N9O14Pureza:98%Forma y color:SolidPeso molecular:1054.32PU-H71 HCl
CAS:PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.Fórmula:C18H22ClIN6O2SPureza:98.95%Forma y color:SoildPeso molecular:548.83αvβ1 integrin-IN-2
CAS:αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively.Fórmula:C29H38N4O4Pureza:98%Forma y color:SolidPeso molecular:506.64Vinblastine
CAS:Vinblastine inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM, used to treat certain kinds of cancer.Fórmula:C46H58N4O9Pureza:97.42%Forma y color:PowderPeso molecular:810.97CYP51/Hsp90-IN-1
CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.Fórmula:C38H40F2N6O4Forma y color:SolidPeso molecular:682.76A-205804
CAS:A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Fórmula:C15H12N2OS2Pureza:98.07% - 98.52%Forma y color:SolidPeso molecular:300.4Ref: TM-T2254
2mg44,00€5mg52,00€10mg81,00€25mg160,00€50mg271,00€100mg532,00€500mg1.169,00€1mL*10mM (DMSO)71,00€GPRP
CAS:GPRP (Gly-Pro-Arg-Pro) is a fibrin polymerization inhibitor.Fórmula:C18H31N7O5Forma y color:White To Off-White PowderPeso molecular:425.48Gap 26
CAS:Gap 26 is a mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.Fórmula:C70H107N19O19SPureza:98.26%Forma y color:SolidPeso molecular:1550.78Bepranemab
CAS:Bepranemab (UCB 0107) - humanized IgG4 monoclonal antibody targeting tau (235-250) for Alzheimer's research.Pureza:95% - 95%Forma y color:LiquidSU6656
CAS:SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.Fórmula:C19H21N3O3SPureza:97% - 98.21%Forma y color:SolidPeso molecular:371.45Ref: TM-T6997
1mg40,00€2mg51,00€5mg85,00€10mg139,00€25mg269,00€50mg449,00€100mg667,00€1mL*10mM (DMSO)88,00€TRC051384
CAS:TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Fórmula:C25H31N5O4Pureza:92.66%Forma y color:SolidPeso molecular:465.54Ref: TM-T3527
1mg37,00€5mg80,00€10mg111,00€25mg210,00€50mg298,00€100mg432,00€200mg622,00€1mL*10mM (DMSO)81,00€Meclofenamic acid
CAS:Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.Fórmula:C14H11Cl2NO2Pureza:98%Forma y color:SolidPeso molecular:296.15Tubulin polymerization-IN-47
CAS:Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancerFórmula:C22H21N3O3Pureza:99.69%Forma y color:SoildPeso molecular:375.42Adhibin
Adhibin is an allosteric inhibitor of RhoGAP class IX myosin (RhoGAP class IXmyosin), effectively inhibiting Myo9 ATPase in both mammals and invertebrates with an IC50 of 2.5 µM and 2.6 µM, respectively. It binds to ATPase, disrupting myosin's motor functions, blocking RhoGTPase-related signaling pathways, and affecting cellular migration, adhesion, and division. Adhibin is applicable for research in cancer metastasis.Fórmula:C13H9Br2NOForma y color:SolidPeso molecular:355.02Terflavoxate
CAS:Terflavoxate is a novel, orally active, semisynthetic statin microtubule inhibitor commonly used in combination with capecitabine.Fórmula:C26H29NO4Pureza:98.07%Forma y color:SolidPeso molecular:419.51Meclofenamic acid sodium
CAS:Meclofenamic acid sodium (Movens), a non-steroidal anti-inflammatory agent, has properties of antipyretic and antigranulation activities.Fórmula:C14H10Cl2NNaO2Pureza:98% - 98.96%Forma y color:SolidPeso molecular:318.14PKCα (C2-4) inhibitor peptide
PKCα (C2-4) inhibitor peptide is a specific antagonist to PKCα that impedes the α1A-adrenoreceptor agonist A-61603 [1] from inhibiting I_Kr.Fórmula:C47H74N14O17Pureza:98%Forma y color:SolidPeso molecular:1107.17TAT-Gap19 acetate
TAT-Gap19 acetate, a Cx43 HC inhibitor, crosses blood-brain barrier, reduces liver fibrosis in mice, and spares Cx43 GJCs.Fórmula:C119H212N46O26Pureza:99.74%Forma y color:SolidPeso molecular:2703.25Dimethylenastron
CAS:Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Fórmula:C16H18N2O2SPureza:98.07%Forma y color:SolidPeso molecular:302.39Ref: TM-T3118
1mg35,00€2mg48,00€5mg62,00€10mg87,00€25mg156,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)67,00€MKLP2-IN-1
CAS:MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.Fórmula:C23H19BrFN3O2Forma y color:SolidPeso molecular:468.318M2698
CAS:M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.Fórmula:C21H19ClF3N5OPureza:99.36%Forma y color:SolidPeso molecular:449.86Ref: TM-T11928
1mg50,00€5mg105,00€10mg170,00€25mg329,00€50mg475,00€100mg655,00€200mg883,00€1mL*10mM (DMSO)123,00€JB061
JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscleFórmula:C19H17NO4Pureza:98.76%Forma y color:SoildPeso molecular:323.34Ref: TM-T67951
1mg39,00€5mg84,00€10mg114,00€25mg202,00€50mg304,00€100mg452,00€500mg938,00€1mL*10mM (DMSO)92,00€KTC1101
CAS:KTC1101 is a pan-PI3K inhibitor with antiproliferative and anticancer activities, reducing phosphorylation of downstream AKT and mTOR.Fórmula:C21H26F2N8O3Pureza:98.75%Forma y color:SoildPeso molecular:476.48Ref: TM-T89831
1mg80,00€5mg158,00€10mg248,00€25mg495,00€50mg800,00€100mg1.283,00€1mL*10mM (DMSO)158,00€BJE6-106
CAS:BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM).Fórmula:C26H23NO2Forma y color:SolidPeso molecular:381.47RO0270608
CAS:RO0270608 is an α4β1/α4β7 integrin antagonist with anti-inflammatory activity for the study of allergic inflammatory responses.Fórmula:C24H19Cl3N2O4Pureza:98.55%Forma y color:SolidPeso molecular:505.78Danegaptide Hydrochloride
CAS:Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.Fórmula:C14H18ClN3O4Pureza:99.55%Forma y color:SolidPeso molecular:327.76Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Fórmula:C46H62N4O11Pureza:99.27% - 99.8%Forma y color:Red-Violet Crystalline PowderPeso molecular:847GNF-5
CAS:GNF-5, non-ATP Bcr-Abl inhibitor (IC50: 0.22±0.1 uM, wild-type), improves upon GNF-2 with better pharmacokinetics.Fórmula:C20H17F3N4O3Pureza:98% - 99.98%Forma y color:SolidPeso molecular:418.37CK-636
CAS:CK-636 (CK-0944636), an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human, fission yeast and bovine Arp2/3 complex.Fórmula:C16H16N2OSPureza:98.10% - 98.88%Forma y color:SolidPeso molecular:284.38Gap 27
CAS:Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.Fórmula:C60H101N15O17Pureza:100%Forma y color:SolidPeso molecular:1304.53Pivanex
CAS:Pivanex, an oral HDAC inhibitor, targets metastasis, angiogenesis, reduces Bcr-Abl protein, and promotes apoptosis.Fórmula:C10H18O4Pureza:≥98%Forma y color:SolidPeso molecular:202.25MMAD
CAS:MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).Fórmula:C41H66N6O6SPureza:99.25% - 99.91%Forma y color:SolidPeso molecular:771.06Tasiamide B
CAS:Tasiamide B is a linear peptide and Cathepsin D inhibitor discovered in the marine cyanobacterium Symploca sp. This compound serves as an excellent template for the development of aspartic protease inhibitors. Tasiamide B effectively targets skin cancer through its strong interaction with the protein HSP90.Fórmula:C50H74N8O12Forma y color:SolidPeso molecular:979.17Crolibulin
CAS:Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.Fórmula:C18H17BrN4O3Pureza:98.19%Forma y color:SolidPeso molecular:417.26Ref: TM-T15012
1mg64,00€2mg92,00€5mg137,00€10mg216,00€25mg376,00€50mg562,00€100mg753,00€1mL*10mM (DMSO)150,00€LXW7 TFA (1313004-77-1 free base)
LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect.Fórmula:C31H49F3N12O14S2Pureza:98%Forma y color:SolidPeso molecular:934.92GSK 3008348 hydrochloride
CAS:GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.Fórmula:C29H37N5O2xHClPureza:99.54%Forma y color:SolidPeso molecular:0Cyclo(RGDyK) trifluoroacetate
CAS:Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.Fórmula:C31H43F6N9O12Pureza:≥95%Forma y color:SolidPeso molecular:847.72SS28
CAS:SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.Fórmula:C18H20O3Pureza:98%Forma y color:SolidPeso molecular:284.35AST 487
CAS:AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.Fórmula:C26H30F3N7O2Pureza:98.17% - 99.56%Forma y color:SolidPeso molecular:529.56Ref: TM-T4053
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg187,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)92,00€Eg5-IN-1
Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.Fórmula:C23H16ClFN4OPureza:98.21%Forma y color:SolidPeso molecular:418.85PKCTheta-IN-2
CAS:PKCTheta-IN-2 (compound 14) is a potent and selective inhibitor of PKCθ, with an IC50 value of 0.25 nM. It demonstrates good selectivity across a broad range of kinases, including the PKC subfamily (30 kinases). Additionally, PKCTheta-IN-2 effectively inhibits the production of IL-2 in mice, where it exhibits an IC50 of 682 nM.Fórmula:C24H23N5O2Forma y color:SolidPeso molecular:413.47Sabeluzole
CAS:Sabeluzole (R-58735) has antiepileptic and cognitive enhancing properties and may be used in the study of Alzheimer's disease.Fórmula:C22H26FN3O2SPureza:99.91%Forma y color:SolidPeso molecular:415.52Zagotenemab
CAS:Zagotenemab: humanized antibody targeting tau protein to study neurological disorders, including Alzheimer's.Pureza:95% - > 95%Forma y color:LiquidPeso molecular:145.3 kDaNilotinib
CAS:Nilotinib (AMN107) is a Bcr-Abl tyrosine kinase inhibitor. Nilotinib has antitumor activity and may be used in CML. Cost-effective and quality-assured.Fórmula:C28H22F3N7OPureza:99.61% - 99.83%Forma y color:Off-White SolidPeso molecular:529.52PKC-iota inhibitor 1
CAS:PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM)Fórmula:C21H22N6OPureza:98.82%Forma y color:SolidPeso molecular:374.44Ref: TM-T8764
1mg113,00€2mg160,00€5mg230,00€10mg369,00€25mg615,00€50mg879,00€100mg1.198,00€500mg2.395,00€1mL*10mM (DMSO)240,00€gp96-II
Gp96-II is a gp96-blocking peptide that antagonizes cytokine production induced by gp96-mediated LPS. This compound is useful for research into inflammatory diseases.Fórmula:C200H353N59O53SForma y color:SolidPeso molecular:4464.37ZINC00640089
CAS:ZINC00640089: Selective LCN2 inhibitor; curbs SUM149 cell growth and AKT activity; useful for IBC research.Fórmula:C20H13F3N2O2Pureza:98.13% - 99.27%Forma y color:SolidPeso molecular:370.32AMP-PCP
CAS:AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.Fórmula:C11H18N5O12P3Pureza:98%Forma y color:SolidPeso molecular:505.21Aurothiomalate tetramer sodium
Aurothiomalate tetramer sodium, a tetrameric form of Aurothiomalate sodium, functions as an anti-arthritis gold agent. It also acts as a potent and selective inhibitor of the oncogenic PKCι signaling pathway.Forma y color:Odour Solid2-Methoxyhydroquinone
CAS:2-Methoxyhydroquinone is a phenolic compound that reduces the production of TNF-α-induced chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. It also serves as a synthetic precursor to the Hsp90 inhibitor Geldanamycin.Fórmula:C7H8O3Forma y color:SolidPeso molecular:140.14Gly3-VC-PAB-MMAE
CAS:Gly3-VC-PAB-MMAE Compound consisting of the ADC linker Gly3-VC-PAB and the microtubule inhibitor MMAE, which can be used to synthesize ADC compounds.Fórmula:C64H103N13O15Forma y color:SolidPeso molecular:1294.58T-900607
CAS:T-900607 is a novel microtubule protein active agent that disrupts microtubule polymerization through a unique mechanism of action. t-900607 is cardiotoxic.Fórmula:C14H10F5N3O4SPureza:99%Forma y color:SolidPeso molecular:411.3HG-7-85-01
CAS:HG-7-85-01 is a novel ATP-competitive and type II tyrosine kinase inhibitor targeting both wild-type and watchman mutant BCR-ABL, PDGFRα, Kit, and Src kinases.Fórmula:C31H31F3N6O2SPureza:98.08%Forma y color:SolidPeso molecular:608.68MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Fórmula:C21H22ClN3OS2Pureza:98.2%Forma y color:SolidPeso molecular:432BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Fórmula:C14H15ClN6OPureza:98% - 99.82%Forma y color:SolidPeso molecular:318.76αvβ6-IN-2
αvβ6-IN-2 (compound 20) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 7.8. It shows potential for use in research on idiopathic pulmonary fibrosis.Fórmula:C25H30F3N3O3Forma y color:SolidPeso molecular:477.523-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Fórmula:C13H11N5O2Pureza:98.84%Forma y color:SolidPeso molecular:269.26Ref: TM-T36123
1mg57,00€5mg120,00€10mg187,00€25mg338,00€50mg512,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)133,00€Elarofiban TFA
CAS:Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.Fórmula:C26H34F6N4O8Pureza:100%Forma y color:SoildPeso molecular:644.56CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Fórmula:C19H18ClN5O2SPureza:98%Forma y color:SolidPeso molecular:415.9Imatinib impurities3
CAS:Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.Fórmula:C24H20ClN5OPureza:97.05%Forma y color:SolidPeso molecular:429.9TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Fórmula:C25H32ClN5O4Pureza:97.55%Forma y color:SolidPeso molecular:502.01AMP-PCP disodium
CAS:AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Fórmula:C11H16N5Na2O12P3Pureza:100%Forma y color:SolidPeso molecular:549.17VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Fórmula:C21H23Cl2N5O2SPureza:98% - 99.16%Forma y color:SolidPeso molecular:480.41Bafetinib
CAS:Bafetinib (INNO-406): Dual Bcr-Abl/Lyn inhibitor; IC50: 5.8/19 nM; ineffective against T315I mutant, less on c-Kit/PDGFR.Fórmula:C30H31F3N8OPureza:94.16% - 99.68%Forma y color:SolidPeso molecular:576.62Ref: TM-T6311
1mg37,00€2mg52,00€5mg79,00€10mg103,00€25mg159,00€50mg188,00€100mg350,00€200mg455,00€1mL*10mM (DMSO)90,00€HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Fórmula:C27H33N5O5Forma y color:SolidPeso molecular:507.58Pyrintegrin
CAS:Pyrintegrin: β1-integrin agonist, boosts embryonic stem cell survival, and podocyte protection, improves cell-matrix adhesion.Fórmula:C23H25N5O3SPureza:97.81%Forma y color:SolidPeso molecular:451.54Ref: TM-T16695
1mg82,00€2mg96,00€5mg159,00€10mg226,00€25mg435,00€50mg648,00€100mg924,00€200mg1.225,00€1mL*10mM (DMSO)168,00€KX2-361
CAS:KX2-361 is a orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastomaFórmula:C24H24FN3O2Pureza:98.52% - 99.86%Forma y color:SolidPeso molecular:405.46Ref: TM-T9411
1mg81,00€5mg170,00€10mg235,00€25mg386,00€50mg543,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)182,00€Erbulozole
CAS:Erbulozole (R 55104) is a synthetic microtubule inhibitor with anti-invasive activity that induces Wernicke's encephalopathy-like neurotoxicity.Fórmula:C24H27N3O5SPureza:99.88%Forma y color:SolidPeso molecular:469.55Darovasertib
CAS:Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).Fórmula:C22H23F3N8OPureza:98.72% - ≥95%Forma y color:SolidPeso molecular:472.47Ref: TM-T5600
1mg52,00€5mg136,00€10mg188,00€25mg350,00€50mg522,00€100mg750,00€200mg1.026,00€1mL*10mM (DMSO)149,00€CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Forma y color:SolidPeso molecular:580.12
