Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Productos de "Señalización citoesquelética"
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PKCθ pseudosubstrate peptide inhibitor,myristoylated
Myristoylated PKCθ pseudosubstrate peptide inhibitor is a synthetic peptide utilized to investigate the mechanism of action of protein kinase C theta (PKCθ) [1Fórmula:C105H184N36O21SPureza:98%Forma y color:SolidPeso molecular:2318.88Miransertib
CAS:Miransertib (ARQ-092) is an orally bioavailable, selective, and potent allosteric Akt inhibitor.Fórmula:C27H24N6Pureza:98.83% - ≥95%Forma y color:SolidPeso molecular:432.52Ref: TM-T3467
1mg52,00€5mg97,00€10mg169,00€25mg344,00€50mg567,00€100mg908,00€500mg1.795,00€1mL*10mM (DMSO)114,00€Defactinib hydrochloride
CAS:Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Fórmula:C20H22ClF3N8O3SPureza:98.06% - 98.78%Forma y color:SolidPeso molecular:546.95Midostaurin
CAS:PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor.Fórmula:C35H30N4O4Pureza:100% - 99.47%Forma y color:SolidPeso molecular:570.64Ref: TM-T3211
1mg51,00€5mg88,00€10mg126,00€25mg216,00€50mg328,00€100mg487,00€500mg1.093,00€1mL*10mM (DMSO)96,00€LY3372689
CAS:LY3372689 (Formulaic Ia) is an orally active O-GlcNAcase (OGA) enzyme inhibitor for tau protein-based disorders including Alzheimer's disease.Fórmula:C16H22FN5O3SPureza:99.27% - 99.45%Forma y color:SolidPeso molecular:383.44Ref: TM-T61661
1mg99,00€5mg235,00€10mg354,00€25mg635,00€50mg935,00€100mg1.415,00€1mL*10mM (DMSO)259,00€Multi-kinase inhibitor 1
CAS:Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) is a Multi-kinase inhibitor.Fórmula:C20H17F3N4O3Pureza:99.34%Forma y color:SolidPeso molecular:418.37FRAX597
CAS:FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).Fórmula:C29H28ClN7OSPureza:97.34% - 99.85%Forma y color:SolidPeso molecular:558.1Ansamitocin P 3'
CAS:Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.Fórmula:C32H43ClN2O9Pureza:98.16% - 99.16%Forma y color:SolidPeso molecular:635.14Ref: TM-T1910
2mg34,00€5mg50,00€10mg84,00€25mg145,00€50mg229,00€100mg340,00€200mg472,00€1mL*10mM (DMSO)70,00€Ifebemtinib
CAS:Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.Fórmula:C28H28F4N6O4Pureza:98.07% - 99.82%Forma y color:SolidPeso molecular:588.55Ionomycin calcium
CAS:Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.Fórmula:C41H70CaO9Pureza:98% - 98.11%Forma y color:SolidPeso molecular:747.07NAMI-A
CAS:NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Fórmula:C8H15Cl4N4ORuSPureza:98%Forma y color:SolidPeso molecular:458.18Ipfencarbazone
CAS:Ipfencarbazone herbicide agent, is a substance being developed for the control of weeds such as watergrass in rice.Fórmula:C18H14Cl2F2N4O2Forma y color:SolidPeso molecular:427.23Dynapyrazole A
CAS:Dynapyrazole A inhibits dynein 1 and 2 (IC50s: 2.3, 2.6 μM) and Hedgehog signaling (IC50: 1.9 μM).Fórmula:C20H12ClIN4OPureza:98.01%Forma y color:SolidPeso molecular:486.69RWJ 50271
CAS:RWJ 50271 inhibits LFA-1/ICAM-1 interaction with IC50 5.0 μM in HL60 cells.Fórmula:C18H17F3N4O2SPureza:99.09%Forma y color:SolidPeso molecular:410.41Ref: TM-T12783
1mg127,00€5mg311,00€10mg472,00€25mg747,00€50mg1.017,00€100mg1.311,00€200mg1.786,00€1mL*10mM (DMSO)344,00€AMP-945
CAS:AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.Fórmula:C28H32F3N5O2Pureza:99.60%Forma y color:SolidPeso molecular:527.58Ref: TM-T9576
1mg97,00€5mg188,00€10mg311,00€25mg533,00€50mg755,00€100mg1.035,00€1mL*10mM (DMSO)254,00€Etrolizumab
CAS:MEDI-578 is a CHO-expressed humanized monoclonal antibody targeting NGF/bNGF for the study of neurological and immune system disorders.Pureza:95% - 95%Forma y color:LiquidAdhesamine diTFA
CAS:Adhesamine diTFA, a dumbbell-shaped molecule, activates the MAPK/FAK pathway. It promotes adhesion and growth in mammalian cells and accelerates differentiation and enhances the survival rate of primary cultured mouse hippocampal neurons.Fórmula:C28H32Cl2F6N8O6S2Forma y color:SolidPeso molecular:825.63BX-2819
CAS:BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Fórmula:C21H24N4O4SPureza:98%Forma y color:SolidPeso molecular:428.51αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).Fórmula:C28H35F3N6O8SPureza:98%Forma y color:SolidPeso molecular:672.67Hydroxy-Dynasore
CAS:Hydroxy-Dynasore (Dyngo-4a) , a effective dynamin inhibitor, inhibits withDynI (brain), DynI (rec), and DynII (rec) of IC50 of 0.38 μM, 1.1 μM, and 2.3 μM,Fórmula:C18H14N2O5Pureza:100% - 97.60%Forma y color:SolidPeso molecular:338.31Ref: TM-T6822
5mg50,00€10mg84,00€25mg137,00€50mg221,00€100mg329,00€200mg490,00€500mg783,00€1mL*10mM (DMSO)55,00€αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Fórmula:C25H32F2N4O3Forma y color:SolidPeso molecular:474.5416-38-Thymosin β4 (cattle) (TFA)
Thymosin β4 (cattle) TFA is a high-affinity activator of MLCK that operates independently of Ca2+ [1].Fórmula:C120H205F3N32O43Pureza:98%Forma y color:SolidPeso molecular:2841.1K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Fórmula:C13H15N3O2SPureza:100%Forma y color:SolidPeso molecular:277.34AZ13705339
CAS:AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM.Fórmula:C33H36FN7O3SPureza:98.57%Forma y color:SolidPeso molecular:629.75FAK-IN-7
CAS:FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.Fórmula:C16H13N3OSPureza:98.2%Forma y color:SolidPeso molecular:295.36AJH-836
CAS:AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFórmula:C22H38O5Pureza:98%Forma y color:SolidPeso molecular:382.5310-Deacetyltaxol
CAS:10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.Fórmula:C45H49NO13Pureza:94.63% - 99.93%Forma y color:SolidPeso molecular:811.87Tadocizumab
CAS:Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Forma y color:LiquidKNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Fórmula:C13H11NO4Pureza:98.90%Forma y color:SolidPeso molecular:245.23PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Fórmula:C25H37FN8O2Pureza:98% - 98.79%Forma y color:SolidPeso molecular:500.61Gamitrinib TPP
CAS:Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.Fórmula:C52H65N3O8PPureza:98%Forma y color:SolidPeso molecular:891.078API-1
CAS:API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .Fórmula:C13H15N5O6Pureza:99.07%Forma y color:SolidPeso molecular:337.29Ref: TM-T8969
1mg59,00€5mg125,00€10mg207,00€25mg376,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)133,00€AKT-IN-1
CAS:AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).Fórmula:C22H21N3OPureza:98.63%Forma y color:SolidPeso molecular:343.42Ref: TM-T4489
1mg113,00€2mg158,00€5mg235,00€10mg400,00€25mg652,00€50mg909,00€100mg1.225,00€1mL*10mM (DMSO)188,00€HSP70/SIRT2-IN-2
CAS:HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Fórmula:C17H13N3S3Pureza:98%Forma y color:SolidPeso molecular:355.5LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Fórmula:C25H25F3N4O4Pureza:98.3% - 99.92%Forma y color:SolidPeso molecular:502.49Ref: TM-T11898
1mg52,00€5mg122,00€10mg185,00€25mg363,00€50mg567,00€100mg690,00€200mg948,00€500mg1.444,00€1mL*10mM (DMSO)135,00€Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Fórmula:C22H30N6O2SPureza:98.98%Forma y color:SolidPeso molecular:442.58AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Forma y color:SolidPeso molecular:381.43Ref: TM-T3068
1mg47,00€2mg60,00€5mg95,00€10mg170,00€25mg299,00€50mg499,00€100mg723,00€1mL*10mM (DMSO)97,00€Bisindolylmaleimide III
CAS:Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6Fórmula:C23H20N4O2Pureza:98.6%Forma y color:SolidPeso molecular:384.43Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Fórmula:C8H7NO2SPureza:99.33% - 99.79%Forma y color:SolidPeso molecular:181.21KP-23172
CAS:KP-23172 is a inhibitor of PI3-K/Akt pathway.Fórmula:C10H4N6OPureza:98%Forma y color:SolidPeso molecular:224.18ML346
CAS:ML346 is a novel activator of Hsp70.Fórmula:C14H12N2O4Pureza:99.25% - 99.29%Forma y color:SolidPeso molecular:272.26Ref: TM-T3594
1mg40,00€2mg52,00€5mg85,00€10mg115,00€25mg172,00€50mg274,00€100mg427,00€500mg938,00€1mL*10mM (DMSO)85,00€Degrasyn
CAS:Degrasyn (WP1130) inhibits DUBs (USP5, UCH-L1, USP9x, USP14, UCH37) and Bcr/Abl without affecting the 20S proteasome.Fórmula:C19H18BrN3OPureza:98.32% - 99.98%Forma y color:SolidPeso molecular:384.27Ref: TM-T6300
2mg44,00€5mg64,00€10mg97,00€25mg198,00€50mg340,00€100mg532,00€200mg747,00€1mL*10mM (DMSO)69,00€Phorbol 12,13-dibutyrate
CAS:Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Fórmula:C28H40O8Pureza:100% - 99.32%Forma y color:SolidPeso molecular:504.61Ref: TM-T16526
1mg62,00€5mg169,00€10mg283,00€25mg557,00€50mg795,00€100mg1.074,00€1mL*10mM (DMSO)180,00€Akt3 degrader 1
CAS:Akt3 degrader 1 counters Osimertinib resistance in NSCLC, inhibits cell growth, and reduces mouse tumors.Fórmula:C53H72N8O4Pureza:98.18% - 99.14%Forma y color:SolidPeso molecular:885.19VTX-27
CAS:VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Fórmula:C20H24ClFN6OPureza:99.49%Forma y color:SolidPeso molecular:418.9Ref: TM-T13314
1mg93,00€2mg125,00€5mg244,00€10mg364,00€25mg562,00€50mg780,00€100mg1.035,00€1mL*10mM (DMSO)225,00€Ruboxistaurin hydrochloride
CAS:Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Fórmula:C28H28N4O3·HClPureza:98.44% - 99.22%Forma y color:SolidPeso molecular:505.01Ref: TM-T3689
1mg71,00€2mg93,00€5mg157,00€10mg256,00€25mg513,00€50mg740,00€100mg1.035,00€500mg2.072,00€1mL*10mM (DMSO)202,00€Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFórmula:C29H31N7OPureza:100% - 99.94%Forma y color:Off White PowderPeso molecular:493.6Tetradecyltrimethylammonium bromide
CAS:Tetradecyltrimethylammonium bromide (MitMAB) is a Dynamin GTPase activity inhibitor and a cationic surfactant with asymmetrical structure.Fórmula:C17H38BrNPureza:100%Forma y color:SolidPeso molecular:336.39K-252b
CAS:K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor.Fórmula:C26H19N3O5Pureza:98%Forma y color:Ready-To-Use SolutionPeso molecular:453.45Larazotide acetate
CAS:Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.Fórmula:C34H59N9O12Pureza:95.53%Forma y color:SolidPeso molecular:785.89
