Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Productos de "Señalización citoesquelética"
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para-Nitroblebbistatin
CAS:para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II.Cost-effective and quality-assured.Fórmula:C18H15N3O4Pureza:100% - 99.92%Forma y color:SolidPeso molecular:337.33Ref: TM-T12360
1mg87,00€5mg212,00€10mg316,00€25mg512,00€50mg695,00€100mg940,00€200mg1.264,00€1mL*10mM (DMSO)215,00€Chromeceptin
CAS:Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.Fórmula:C19H16F3N3OPureza:99.72%Forma y color:SoildPeso molecular:359.35Ref: TM-T60055
5mg50,00€10mg74,00€25mg140,00€50mg197,00€100mg306,00€200mg442,00€1mL*10mM (DMSO)51,00€PU-H71
CAS:PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.Fórmula:C18H21IN6O2SPureza:98.31%Forma y color:SolidPeso molecular:512.37Delcasertib
CAS:Delcasertib (KAI-9803) is a potent and selective inhibitor of δ-protein kinase C (δPKC).Fórmula:C120H199N45O34S2Pureza:99.96%Forma y color:SolidPeso molecular:2880.28Ref: TM-T11740
1mg202,00€5mg512,00€10mg740,00€25mg1.121,00€50mg1.539,00€100mg2.072,00€1mL*10mM (DMSO)1.691,00€1-Oleoyl-2-acetyl-sn-glycerol
CAS:1-Oleoyl-2-acetyl-sn-glycerol (1-oleoyl-2-acetyl-glycerol) is a PKC activator that induces superoxide production.Fórmula:C23H42O5Forma y color:SolidPeso molecular:398.58Nilotinib hydrochloride
CAS:Nilotinib HCl (AMN-107 HCl), an oral Bcr-Abl inhibitor, targets neuroinflammation, cognitive issues, and chronic myelogenous leukemia.Fórmula:C28H23ClF3N7OPureza:100%Forma y color:SolidPeso molecular:565.98Hispidin
CAS:Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective propertiesFórmula:C13H10O5Pureza:98.27%Forma y color:White Crystalline PowderPeso molecular:246.22Ref: TM-T7792
1mg88,00€5mg187,00€10mg298,00€25mg533,00€50mg747,00€100mg1.017,00€1mL*10mM (DMSO)207,00€SB-743921 hydrochloride
CAS:SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).Fórmula:C31H34Cl2N2O3Pureza:95.58% - 99.70%Forma y color:SolidPeso molecular:553.52Ref: TM-T2255
1mg42,00€5mg106,00€10mg163,00€25mg278,00€50mg429,00€100mg657,00€500mg1.501,00€1mL*10mM (DMSO)130,00€PPY A
CAS:PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinase and inhibits the growth of Bcr-Abl T315l mutant or wild-type Bcr-Abl gene-transformed cellsFórmula:C22H20N4O2Pureza:98.77%Forma y color:SolidPeso molecular:372.42ILK-IN-2
CAS:ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.Fórmula:C30H30F3N5OPureza:99.30%Forma y color:SolidPeso molecular:533.59Ref: TM-T5488
1mg48,00€5mg97,00€10mg128,00€25mg162,00€50mg192,00€100mg281,00€200mg408,00€1mL*10mM (DMSO)137,00€Rosabulin
CAS:v Rosabulin (STA 5312) is an orally active microtubule inhibitor with potency.Fórmula:C22H16N4O2SPureza:98.06%Forma y color:SolidPeso molecular:400.45Ref: TM-T16788
1mg97,00€5mg243,00€10mg364,00€25mg658,00€50mg938,00€100mg1.415,00€1mL*10mM (DMSO)265,00€Arg-Gly-Asp-Ser acetate
Arg-Gly-Asp-Ser acetate targets integrin, binding pro-caspase-8, -9, -3, but not -1; inhibits receptor function.Fórmula:C17H31N7O10Pureza:98.14%Forma y color:SolidPeso molecular:493.47Hsp90-IN-34
CAS:Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Fórmula:C22H14F2N6OForma y color:SolidPeso molecular:416.38Mivobulin
CAS:Mivobulin is an inhibitor of tubulin .Fórmula:C17H19N5O2Pureza:98%Forma y color:SolidPeso molecular:325.37FPA-124
CAS:FPA-124 is a cell-permeable copper complex that acts as a selective Akt (protein kinase B) inhibitor to induce apoptosis in a variety of cancer cell lines.Fórmula:C11H9Cl2CuN3O2SPureza:95.04%Forma y color:SolidPeso molecular:381.73ZLY06
CAS:ZLY06 is a dual agonist of peroxisome proliferator-activated receptors (PPAR) δ and γ with oral activity (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). It mediates the upregulation of CD36 and induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1. Moreover, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, primarily by enhancing the β-oxidation of fatty acids and reducing hepatic lipid synthesis, thereby alleviating fatty liver disease.Fórmula:C25H26O6Forma y color:SolidPeso molecular:422.47ATN-161 trifluoroacetate salt
CAS:ATN-161 TFA salt, a new integrin α5β1 inhibitor, curbs angiogenesis, liver metastases growth, enhances survival in mice.Fórmula:C25H36F3N9O10SPureza:98% - 99.98%Forma y color:SolidPeso molecular:711.67PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Forma y color:SolidPeso molecular:501.5Catumaxomab
CAS:Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.Pureza:95%Forma y color:LiquidCK-869
CAS:CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor(IC50 of 7 μM),and is useful tools for the investigation of the Arp2/3 complex.Fórmula:C17H16BrNO3SPureza:99.85%Forma y color:SolidPeso molecular:394.28Zelavespib hydrochloride
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.Pureza:98%Forma y color:Odour SolidSC79
CAS:SC79 is an AKT agonist with specificity and blood-brain barrier permeability.Fórmula:C17H17ClN2O5Pureza:98% - 99.93%Forma y color:SolidPeso molecular:364.78β-glycosidase-IN-1
CAS:β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.Fórmula:C13H23NO5Pureza:98%Forma y color:SolidPeso molecular:273.33A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Fórmula:C12H14Cl2N2O2SPureza:99.32%Forma y color:SolidPeso molecular:321.22Ref: TM-T14069
1mg35,00€5mg66,00€10mg96,00€25mg170,00€50mg274,00€100mg439,00€500mg938,00€1mL*10mM (DMSO)90,00€(8R)-8-Hydroxyepoxyboetirane A
(8R)-8-Hydroxyepoxyboetirane A is a neuroactivating compound that interacts with PKCδ-C1B. This compound binds into the PKC enzyme pocket through hydrogen bonds with glycine-253, leucine-251, and threonine-242. It induces the release of NRG1 and promotes the differentiation of neural stem cells into neurons. (8R)-8-Hydroxyepoxyboetirane A holds potential for research into nervous system disorders.Forma y color:Odour SolidTASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFórmula:C13H17N5O3SPureza:98.14%Forma y color:SolidPeso molecular:323.37Ref: TM-T7879
1mg55,00€5mg117,00€10mg187,00€25mg315,00€50mg449,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)134,00€Orbofiban TFA
CAS:Orbofiban TFA is an orally active GPIIb/IIIa platelet receptor antagonist with inhibitory effects on platelet aggregation for the study of unstable coronaryFórmula:C19H24F3N5O6Pureza:97.45% - 98.43%Forma y color:SolidPeso molecular:475.42HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFórmula:C13H12O4SPureza:99.51%Forma y color:SolidPeso molecular:264.3Ref: TM-T7265
1mg130,00€2mg185,00€5mg311,00€10mg472,00€25mg753,00€50mg1.064,00€100mg1.415,00€1mL*10mM (DMSO)455,00€Firategrast
CAS:Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervousFórmula:C27H27F2NO6Pureza:99.16%Forma y color:SolidPeso molecular:499.5Ref: TM-TQ0291
1mg47,00€5mg87,00€10mg140,00€25mg283,00€50mg464,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)97,00€Vevorisertib trihydrochloride
CAS:Vevorisertib trihydrochloride (ARQ 751 trihydrochloride) is ainhibitor of pan-AKT and AKT1-E17K mutations, inhibiting AKT1, AKT2 and AKT3.Fórmula:C35H41Cl3N8OPureza:98.28%Forma y color:SolidPeso molecular:696.12Ref: TM-T38846
1mg70,00€5mg149,00€10mg230,00€25mg393,00€50mg552,00€100mg740,00€200mg1.130,00€1mL*10mM (DMSO)212,00€Teprenone
CAS:Teprenone (Geranylgeranylacetone) is a anti-ulcer drug, and works as an inducer of heat shock proteins (HSPs).Fórmula:C23H38OPureza:99.76% - 99.96%Forma y color:SolidPeso molecular:330.55FAK-IN-14
CAS:FAK-IN-14 is a FAK inhibitor that induces apoptosis and cell cycle arrest. FAK-IN-14 has a more significant inhibitory effect on FAK, FGFR1 and Pyk2.Fórmula:C21H24BrN7OSPureza:99.7%Forma y color:SoildPeso molecular:502.43BNC105
CAS:BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.Fórmula:C20H20O7Pureza:96.57%Forma y color:SolidPeso molecular:372.37Ref: TM-T14694
1mg84,00€5mg160,00€10mg226,00€25mg371,00€50mg520,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)170,00€Teclistamab
CAS:Teclistamab(JNJ-64007957) is a human bispecific monoclonal antibody targeting the CD3 receptor on t-cells and the BCMA for relapsed and refractory multiple myeloma.Pureza:95%Forma y color:LiquidPentachloropseudilin
CAS:Pentachloropseudilin inhibits Myosin-1 and speeds up TGF-β receptor turnover, suppressing TGF-β activity.Fórmula:C10H4Cl5NOPureza:98.14%Forma y color:SolidPeso molecular:331.41PF-562271
CAS:PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Fórmula:C21H20F3N7O3SPureza:100% - 97.65%Forma y color:SolidPeso molecular:507.49Ref: TM-T2465
1mg59,00€5mg127,00€10mg159,00€25mg240,00€50mg378,00€100mg567,00€200mg793,00€1mL*10mM (DMSO)140,00€Akt1 and Akt2-IN-1
CAS:Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM). It has potent and balanced activity.Fórmula:C33H29N7OForma y color:SolidPeso molecular:539.63cSRC/BCR-ABL-IN-1
cSRC/BCR-ABL-IN-1 (compound 21b) is a potent inhibitor of Bcr-Abl and C-Src, with IC50 values of 56.2 nM and 101 nM, respectively. It exhibits cytotoxicity.Fórmula:C29H31Cl2N5O4Peso molecular:584.494ε-V1-2, Cys-conjugated
Epsilon-V1-2, a Cys-conjugated, is a biologically active peptide known as the εPKC-specific inhibitor.Fórmula:C40H70N10O14SPureza:98%Forma y color:SolidPeso molecular:947.11Miltefosine
CAS:Miltefosine (HePC), effective oral drug for both visceral and cutaneous leishmaniasis, in clinical trials worldwide.Fórmula:C21H46NO4PPureza:98% - 99.87%Forma y color:White To Off-White PowderPeso molecular:407.57SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Fórmula:C36H34BrClFN5OPPureza:98%Forma y color:SolidPeso molecular:718.02HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Forma y color:Pale Yellow Crystalline SolidPeso molecular:277.3420-HETE
CAS:20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.Fórmula:C20H32O3Pureza:99.79%Forma y color:SolidPeso molecular:320.47Ref: TM-T14021
1mg (312.04μM*10mL in Ethanol)1.139,00€5mg (312.04μM*50mL in Ethanol)2.327,00€100μg (312.04μM*1mL in Ethanol)474,00€PKCiota-IN-2
CAS:PKCiota-IN-2 selectively inhibits PKC-ι (IC50=2.8nM) and also blocks PKC-α, ε (IC50s=71nM, 350nM).Fórmula:C24H21N5OPureza:99.74%Forma y color:SolidPeso molecular:395.46Ref: TM-T9863
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€1mL*10mM (DMSO)279,00€(E)-Akt inhibitor-IV
CAS:(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.Fórmula:C31H29IN4SPureza:99.01% - 99.74%Forma y color:SolidPeso molecular:616.56Ref: TM-T9393
1mg55,00€5mg116,00€10mg180,00€25mg338,00€50mg469,00€100mg655,00€200mg924,00€1mL*10mM (DMSO)157,00€Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Fórmula:C24H30O9Pureza:98.18% - 99.22%Forma y color:SolidPeso molecular:462.49Taurochenodeoxycholic acid sodium
CAS:Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Fórmula:C26H44NNaO6SPureza:98.23% - 99.45%Forma y color:White To Off-White PowderPeso molecular:521.68Arimoclomol maleate
CAS:Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.Fórmula:C18H24ClN3O7Pureza:99.9% - 99.98%Forma y color:SolidPeso molecular:429.85Ombrabulin hydrochloride
CAS:Ombrabulin hydrochloride is a synthetic, selective CA-4 phosphate ester or derivative of Ombrabulin to disrupt the tubulin cytoskeleton of endothelial cells andFórmula:C21H27ClN2O6Pureza:98%Forma y color:SolidPeso molecular:438.9Roslin 2 bromide
CAS:Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.Fórmula:C13H19BrN4Pureza:97.07%Forma y color:SolidPeso molecular:311.22
