Heterociclos con nitrógeno (N)

6-Nitropiperonyl alcohol is a polymerase inhibitor that prevents the production of DNA, RNA, and proteins. It binds to the active site of polymerases by competitive inhibition and inhibits the incorporation of triphosphates into the growing nucleic acid chain. 6-Nitropiperonyl alcohol has been shown to inhibit the activity of all three types of polymerases: DNA-, RNA-, and protein-dependent polymerases. This drug can be used for the treatment of cancers associated with the overproduction of these proteins. The photochemical properties of 6-nitropiperonyl alcohol have also been studied. When exposed to UV light, 6-nitropiperonyl alcohol undergoes photochemical reactions in which it forms nitrobenzaldehyde, which then reacts with urea to produce anions (e.g., nitrite). These anions can be used as markers for polymers during patterning processes such as lithography and microfabrication.

Please enquire for more information about 6-Propyl-pyridin-2-ylamine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Quinoline-3-sulfonyl chloride is a disulfonate that has cytotoxic effects on cancer cells. It has been shown to inhibit the growth of breast cancer cells in vitro and in vivo. Quinoline-3-sulfonyl chloride inhibits the production of reactive oxygen species and stimulates cell death by reacting with cysteine residues in proteins. This compound also suppresses the activity of human cytochrome P450 enzymes, which may be due to its regiospecificity for the Cys residue at position 47. The drug is not active against cisplatin or chlorinated compounds, such as human cytochrome P450 enzymes.

Please enquire for more information about Piperidine-3-carboxylic acid(4-nitro-phenyl)-amide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about tert-Butyl (6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)carbamate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-Pyridin-4-yl-propionamidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-(4-Bromophenyl)-4,6-dichloropyrimidine is a reactant used in the synthesis of Macitentan, an orally active dual endothelin receptor antagonist. References Bolli, M. et al.: J. Med. Chem., 55, 7849 (2012);

Please enquire for more information about 2,6-Dimethyl-4-(1-naphthyl)pyridine-3,5-dicarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(6-Bromopyridin-2-yl)benzaldehyde including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Lercanidipine Impurity 21 monohydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

2-Amino-4-fluoropyridine is an acylation reaction product of 2-amino-4-chloropyridine and a fatty acid. The diaminopyridine moiety is responsible for the inhibition of copper enzymes. In addition, fluorine substitution provides a higher operational stability. The synthesis of this compound is accomplished through the use of thionyl chloride in an operational procedure that includes heating at 180 °C for 4 hours. 2-Amino-4-fluoropyridine has been shown to be effective against some bacteria such as Mycobacterium tuberculosis and Legionella pneumophila, which are resistant to other agents. This drug also has antiplasmodial properties and can be used to treat malaria. The structure based design of this molecule was optimized by replacing chlorine with fluorine as well as introducing a n oxide group to provide a sterically more favorable conformation.

Please enquire for more information about 4,6-Dimethyl-2-pyridinemethanol including the price, delivery time and more detailed product information at the technical inquiry form on this page

4-Nitropyridine-2-carboxylic acid1-oxide is a chromophore that can be observed in the solid state by powder diffraction analysis. It is characterized as an intramolecular hydrogen bond donor, also known as a hydrogen bond acceptor. The crystallographic data for 4-Nitropyridine-2-carboxylic acid1-oxide show that it has a monoclinic crystal system and space group P21/n with lattice parameters a=12.5, b=11.5, c=7.5 and beta=-120 degrees. The molecule has two nitro groups on the pyridine rings, which are responsible for its yellow color. 4-Nitropyridine-2-carboxylic acid1-oxide also has fluorescence properties, which are observed when irradiated with UV light at 365 nm.

Applications 1-Piperidin-2-ylacetone Hydrochloride is an intermediate used in the synthesis of 1-Piperidin-2-ylacetone (B449983), which is a useful research chemical.

Please enquire for more information about 4-Chloropiperidine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-Chloro-6-isopropoxypyrimidin-2-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(1H-Pyrazol-3-ylcarbonyl)piperidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-Fluoro-3-nitropyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(2-(Methylsulfonyl)phenyl)piperazine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-(4-hydroxy-1H-pyrazolo[3,4-d]pyrimidin-6-yl)isobutyramide including the price, delivery time and more detailed product information at the technical inquiry form on this page

2,4,6-Tribromopyrimidine is a heterocycle that contains three bromine atoms. It has magnetic properties and can be used to study biomolecules such as proteins. 2,4,6-Tribromopyrimidine has been synthesised from pyrrole and fluorine, which are both polyhalogenated. The chemical shift of 2,4,6-Tribromopyrimidine is found at about 4 ppm in the proton NMR spectrum, which is due to its anion character. This compound also has a nuclear spin of I=3/2 and anisotropy parameters of γ=1.8 and χ=0.5.

2,6-Pyridinedicarboxylic acid monomethyl ester (2,6-PDA) is an organic compound that is used in analytical chemistry to introduce fatty acids into non-polar solvents. 2,6-PDA can be synthesized from the reaction of pyridine and acetic acid. The introduction of fatty acids into non-polar solvents is a necessary first step for analysis by liquid chromatography. This process can be done by using 2,6-PDA as an intermediate. The melting point of 2,6-PDA is about 170°C and it decomposes at a temperature of about 220°C. The purified 2,6-PDA should be stored in a cool place or refrigerated to prevent decomposition.

1-Methyl-piperidine-3-carboxylic acid methyl ester (1MPCE) is a phenyloxadiazolyl derivative that was synthesized to investigate the effects of oxadiazole derivatives on Alzheimer's disease. 1MPCE and its metabolites are able to cross the blood brain barrier and have been shown to have a high affinity for the hippocampus and forebrain regions of the brain. 1MPCE has been shown to have an inhibitory effect on acetylcholinesterase, an enzyme that breaks down acetylcholine in the nervous system. This inhibition leads to an increase in acetylcholine levels, which may be beneficial for patients with Alzheimer's disease.

Please enquire for more information about 2-(Methylcarboxy)pyridine-5-boronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-(Chloromethyl)-2-methylpyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Ethyl 7-cyclopropyl-2-phenylpyrazolo[1,5-a]pyrimidine-6-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-(4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl)isobutyramide including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(3-Azido-3-deoxy-beta-D-ribofuranosyl)-5-nitropyridine-2(1H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Chloro-2-(ethylthio)pyrimidine-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 3-Chloro[1,2,4]Triazolo[4,3-a]Pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Chloro-3-bromo-5-aminopyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Pyrimidine-2,4,6-triol is a pentacyclic triterpene that has been shown to have anticancer properties and may be an effective treatment for cancer. Studies have shown that pyrimidine-2,4,6-triol inhibits the growth of tumor cells by inhibiting the production of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system. Pyrimidine-2,4,6-triol also increases dopamine levels in the brain and has antiinflammatory activity. Pyrimidine-2,4,6-triol is one of two tautomers of malonic acid; it can exist as either a keto or enol form. The keto form is more stable than the enol form because of its increased resonance stabilization energy.

(S)-Piperidin-2-ylmethanol is a chiral chemical compound that is used to synthesize other chiral compounds. It has been shown to be effective in the asymmetric synthesis of heterocycles, and it can be used as a precursor for the synthesis of piperidine derivatives, which are used in pharmacology and biochemistry. (S)-Piperidin-2-ylmethanol can also be used to modify biomolecules with its stereoselective reactivity. This chemical is useful in the study of protein folding and enzyme inhibition.

Applications 3-Chloropyridine-d4 (CAS# 1001003-95-7) is a useful isotopically labeled research compound.

1-(2-Methoxyphenyl)piperazine is a drug that has been shown to have locomotor activity, antihypertensive activity, and inhibitory properties. It also acts as a matrix effect and receptor activity. 1-(2-Methoxyphenyl)piperazine has been shown to have inhibitory effects on 5-ht7 receptors, which are mainly found in the brain. This drug binds to the 5-ht2 receptor, which is a type of serotonin receptor in the brain. The binding of 1-(2-methoxyphenyl)piperazine to the 5-ht2 receptor inhibits the release of dopamine from neurons and leads to necrotic cell death. This drug can also be used as an analytical tool for measuring 5-ht1a receptors, which is a type of serotonin receptor found in the brain.

Please enquire for more information about 2-(CyclopropylaMino)pyriMidine-5-boronic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

1,2,4-Triazole is a heterocyclic compound that is used as an intermediate in the synthesis of many other organic compounds. It can be obtained by reacting trifluoroacetic acid with nitrobenzene in the presence of ammonia. This reaction yields a protonated 1,2,4-triazole and ammonium chloride as byproducts. The thermodynamic data for this compound has been determined using an electrochemical impedance spectroscopy method and it was found that the protonation state of 1,2,4-triazole depends on pH. 1,2,4-Triazole has been shown to cause genotoxic effects in carcinoma cell lines. It is also capable of inhibiting the growth of bacteria by binding to nitrogen atoms present on their surface. This leads to a decrease in bacterial activity and may be useful for biological treatment purposes. Nitro groups are able to react with 1,2,4

Please enquire for more information about 6-Methyl-3-oxo-2,3-dihydropyridazine-4-carboxylicacid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 4-Amino-2-chloropyrimidine-5-carboxylicacid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Bromo-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2-(1-Piperazinyl)-phenol Dihydrochloride, is used to prepare nonpeptidic biaryl inhibitors of human cathepsin K in relation to treatment of osteoporosis. It is also used to synthesize serotonin transporters/histamine H3 receptors. References Robichaud, J., et al.: J. Med. Chem., 46, 3709 (2003); Keith, J., et al.: Bioorg. Med. Chem. Lett., 17, 702 (2007)

Please enquire for more information about 1-Benzoylpiperidin-3-amine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),

1-(4-Methoxybenzyl)piperazine is a chemical compound that has been shown to have inhibitory activities against cancer cells. It also shows potential for the treatment of type 2 diabetes and Alzheimer's disease. The mechanism of action is not well understood, but it may be due to its ability to induce mitochondrial biogenesis and insulin sensitivity. 1-(4-Methoxybenzyl)piperazine has also been shown to improve memory in rats with spontaneous dementia, similar to the effects of donepezil (a drug used for Alzheimer's disease). 1-(4-Methoxybenzyl)piperazine can be taken orally or administered via injection.

Please enquire for more information about 4,6-Dichloro-7H-pyrrolo[2,3-d]pyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about Methyl 2-(4,5-dimethoxy-2-(piperid-1-ylsulfonyl)phenyl)acetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2-Chloro-5-nitropyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS). References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)

Please enquire for more information about 1-(3,4-Difluorophenyl)piperidin-4-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 2-Bromo-6-chloro-4-pyridinecarboxylic Acid Methyl Ester, can be used as an intermediate in the preparation of Trifluoromethyl-Substituted pyridines, possessing wide range of bioactivites. References Cottet, F., et al.: Eur. J. Org. Chem., 327 (2002);

Please enquire for more information about 4,6-Dichlorothieno[2,3-b]pyridine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Chloro-2-ethynylpyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page