Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

2-Chloro-3-methyl-8-trifluoromethoxyquinoline

2-Phenylmalonamide is a heterocyclic compound with a carbocyclic ring. It is a potent antitumor agent that has been shown to inhibit tumor growth and induce cell differentiation. The compound has shown potent anti-inflammatory activity as well as a proliferative effect on cells in culture. 2-Phenylmalonamide also inhibits the production of cytokines and chemokines, which are factors involved in inflammatory responses. This drug can be used for the treatment of autoimmune diseases and inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis, and psoriasis. 2-Phenylmalonamide may be useful for treating cancer in bladder cancer or other malignancies. This drug also inhibits the production of proinflammatory cytokines and chemokines including TNF-α, IL-1β, IL-6, IL-8, MCP1, GMCSF, IFNγ,

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Chloroisoquinoline-7-carbonitrile

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Trifluoromethyl)pyridazine

Ethyl 5-amino-1-{4-[chloro(difluoro)methoxy]phenyl}-1H-pyrazole-4-carboxylate

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3-Amino-6-chloropyridine-2(1H)-thione is a heterocyclic compound with the chemical formula NHClPS. It is an analog of pyridine and has been shown to be a potent inhibitor of the enzyme hydroxide. The following are some examples: "Rifapentine is an anti-tuberculosis drug that belongs to the class of rifamycins." "Tilmicosin is a macrolide antibiotic that inhibits the growth of bacteria by binding to the 50S ribosomal subunit." "3-Desacetylcefotaxime potassium (3DCTKP) is an antibacterial agent that belongs to the group of β-lactam antibiotics." "Gatifloxacin is a fluoroquinolone antibiotic that inhibits the DNA gyrase and topoisomerase IV, which are enzymes that

Versatile small molecule scaffold

1H-Pyrrolo[3,2-c]pyridine-3-carbaldehyde

Versatile small molecule scaffold

2-Hydroxy-5-(methylthio)benzaldehyde (HMB) is a ligand that binds reversibly to a copper ion in the active site of many enzymes. It has been shown to react as a bidentate ligand, forming a tripodal complex with two axial and two equatorial coordination sites. HMB also reacts with perchlorates, forming an ionic complex that is soluble in organic solvents such as dichloromethane or chloroform. The protonation of HMB at the phenolic hydroxyl group leads to its formation of an ionic complex with the axial Cu(I) ion. This reaction is favored by low pH, which causes deprotonation of the hydroxyl group. The reaction can be observed by electrochemical studies. 2-hydroxy-5-(methylthio)benzaldehyde (HMB) is a ligand that binds reversibly to a copper ion in

This is a research chemical that demonstrates the potential to be used as a drug substance. It has been studied for its mechanisms and cost-effectiveness. This compound exemplifies strategies for pharmaceutical development and commercialization, including how to manage the lifecycle of a substance.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-(Pyrrolidin-3-yloxy)pyrimidine hydrochloride

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

tert-Butyl 3-(3-(bromomethylene)cyclobutyl)azetidine-1-carboxylate

Pyrvinium pamoate is an anthelmintic drug that is used to treat parasitic worm infections. It has been shown to have potent antitumor activity and has been used in the treatment of a variety of cancers, including breast cancer. Pyrvinium pamoate can inhibit tumor cell viability by interfering with energy metabolism and mitochondrial membrane potential. It also inhibits the production of growth factor-β1, which is involved in carcinogenesis. This drug has been shown to cause cellular necrosis, apoptosis, and autophagy in experimental models. Pyrvinium pamoate can be used as a pharmacokinetic probe for studying drug transport across the blood-brain barrier.

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Bromo-6-(trifluoromethyl)-1,3-benzoxazole

Versatile small molecule scaffold

Versatile small molecule scaffold

5-Bromo-2-chloro-6-methyl-3-nitropyridine

Azepane-2-carboxylic acid is a chiral compound that can be obtained by the asymmetric synthesis of a diamino amide. It has been used to synthesize cyclic imino compounds in high yields and as an oxidizing agent for ruthenium. Azepane-2-carboxylic acid can also be used as a dehydrogenase, which is an enzyme that catalyzes the oxidation of organic substances like carbohydrates, fats, and alcohols to produce energy. This molecule has been shown to have strong acidity due to its carbonyl group. It is also able to act as an acid dehydrogenase, which is an enzyme that catalyzes oxidation of fatty acids with NAD (nicotinamide adenine dinucleotide) or NADP (nicotinamide adenine dinucleotide phosphate) to form acetyl CoA or acetoacetyl CoA.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Cyclobutanethiol is a 1-cyclopentene-1-carboxylic acid, which is a cyclic form of the alkylthio group. It is an organic solvent with a hydroxyl group at one end and an alkyl group at the other end. Cyclobutanethiol can be used as a sealant or as a solvent in organic chemistry. The compound has been shown to inhibit insulin resistance by binding to cb1 receptors on cells, thereby inhibiting the production of glucose. Cyclobutanethiol also absorbs ultraviolet light, so it can be used in photochemistry.

Versatile small molecule scaffold

Nitrobenzene is a chemical that is used in wastewater treatment. It reacts with sodium carbonate to form sodium nitrite and hydrogen fluoride. The reaction mechanism is not well understood, but it is thought that the hydrogen fluoride acts as a catalyst for the reaction. Nitrobenzene has been shown to have transport properties in natural water systems. It can be found in the environment from industrial waste or from the combustion of fossil fuels. Nitrobenzene has been shown to cause chronic exposure when ingested by humans and animals, as well as structural changes in DNA, which may lead to cancer. Nitrobenzene can also react with an inorganic acid to form an organic compound called a nitrosamine. These compounds are carcinogenic and mutagenic, and have been linked to various cancers such as bladder cancer, stomach cancer, pancreatic cancer, lung cancer, breast cancer, esophageal cancer and liver cancer. The most common nitrosamines are N-nit

Versatile small molecule scaffold

Versatile small molecule scaffold

tert-Butyl 2-chloro-5-methylpyridin-4-ylcarbamate

5,6-Dihydrobenzo[h]quinazolin-2-ol

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Moroxydine hydrochloride is a natural compound that has been shown to have anti-infective properties. It has been used as a plate test to identify infectious diseases and resistant mutants, as well as an analytical method for measuring the concentration of proteins in biological samples. Moroxydine hydrochloride is used in experimental models to study the response element and matrix effect, which are factors that affect enzyme activity. This drug also has protein genes that can inhibit viruses. Moroxydine hydrochloride can be used as an inhibitor of virus replication and is effective against HIV-1 and hepatitis C virus (HCV) in human serum. The drug was also shown to be active against herpes simplex virus type I (HSV-1).

Versatile small molecule scaffold

Versatile small molecule scaffold

[(4-Hydroxy-6-methylpyrimidin-2-yl)amino]formonitrile is a pyrimidine antagonist. It inhibits the activity of guanidines, which are compounds that play a role in the metabolism of nucleotides. This drug also has metabolic stability and in vitro metabolic activity. It is an important tool for studying the structure activity relationship of guanidines.

Versatile small molecule scaffold

5-Amino-2-bromopyridine

Versatile small molecule scaffold

Versatile small molecule scaffold

N-Boc-endo-3-aminotropane

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Imidazo[1,2-a]pyrimidine-2-carboxaldehyde is a biologically active compound that is synthesized through a multicomponent reaction. The synthesis of imidazo[1,2-a]pyrimidine-2-carboxaldehyde requires sodium carbonate and malononitrile as starting materials. The reactants are activated with enolizable reagents such as pyran or acetone before being subjected to the reaction. This process yields target compounds with high yields and excellent spectroscopic properties.

Versatile small molecule scaffold

Versatile small molecule scaffold

Pyridine-3,5-dicarboxylic acid

2-Chloro-5H-pyrrolo[2,3-b]pyrazine

1-(2,4-Diethoxyphenyl)ethanone is a substrate for the benzene ring and alkoxy group. It has been shown to undergo efficient cyclization with furan and substituted in the 1-position with alkyl, aryl, or other electron-withdrawing groups. In addition, this compound is fluorescent and can be used as an advance in organic chemistry.

1-(Toluene-4-sulphonyl)-1H-imidazole

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

3,4-Dimethylthiophene is a reactive chemical that has been used in the treatment of acne. It also has been shown to be an effective antimicrobial agent against resistant strains of microorganisms such as methicillin-resistant Staphylococcus aureus and methicillin-resistant Enterococcus faecalis. 3,4-Dimethylthiophene is activated by metal cations and fatty acids in the cell membrane, which leads to bond cleavage and the production of reactive oxygen species. The reaction time for this process varies depending on the type of fatty acid used but can be as short as 10 minutes. 3,4-Dimethylthiophene is synthesized from isoprene with an activation energy of 118 kJ/mol. The functional theory explains how this reaction occurs with an electron transfer from the methyl group to form a radical cation, which reacts with oxygen to form a peroxy radical.