Antimicrobianos

Butoconazole nitrate is an antifungal agent and is used for the treatment of vaginal yeast infections. It inhibits the synthesis of ergosterol, disrupting the fungal cell membrane.

Fenaminostrobin is a broad-spectrum fungicide, which is synthesized chemically. It operates primarily through inhibition of mitochondrial respiration in fungal cells, targeting the bc1 complex, which disrupts ATP production and leads to the inhibition of spore germination and fungal growth. This mode of action makes Fenaminostrobin effective against a wide range of pathogenic fungi that affect various crops. In agriculture, Fenaminostrobin is applied to control diseases such as powdery mildew, rusts, and leaf spots across cereals, fruits, and vegetables. It is valued not only for its protective capabilities but also for its curative actions on established infections. The chemical stability and systemic activity of Fenaminostrobin allow it to be absorbed and translocated within plant tissues, providing comprehensive protection. Its efficacy at lower application rates also contributes to its use in integrated pest management strategies.

Amphotericin B is a macrocycle antibiotic first isolated from Streptomyces nodosus. Its antifungal activity is exerted by interacting with the fungal membrane, mainly ergosterol, and inducing pore formation. The increase in membrane permeability causes loss of ions and cell death. The C-2’ hydroxyl residue of the mycosamine carbohydrate moiety in the structure seems to have a major role in binding to ergosterol. It is used in cell culture to prevent growth of microbial contaminants, such as yeast and fungi. It is recommended by the WHO and CDC as an antifungal component for VTM at a concentration of 250ug/ml.

Applications (R)-(+)-Camphor is a terpenoid with a wide variety of use. (R)-(+)-Camphor has insecticidal activity and is also used as an antimicrobial agent. (R)-(+)-Camphor is used as a culinary flavouring agent in parts of asia. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Abdelgaleil, S.A.M. Appl. Entomol. Zool., 45, 425 (2010); Tabanca, N. et al.: J. Agric. Food. Chem., 49, 4300 (2001);

Flavomycin - 8% premix is an antibacterial feed additive with action on bacterial cell wall synthesis and is used for promoting growth and improving feed efficiency in livestock and poultry.

N-Demethyl rifampin is a metabolite of rifampin, which is a natural product derivative. Rifampin itself is a well-known antibiotic derived from the bacterium *Amycolatopsis rifamycinica*. N-Demethyl rifampin is formed through the metabolic process where rifampin undergoes demethylation. This transformation occurs primarily in the liver, mediated by the cytochrome P450 enzyme system. This compound retains the core antibacterial properties of its parent molecule by targeting the bacterial DNA-dependent RNA polymerase. Its inhibitory action disrupts RNA synthesis, ultimately suppressing bacterial replication. This mode of action makes it particularly valuable in the study of bacterial resistance mechanisms and the exploration of rifamycin derivatives' pharmacokinetics and dynamics. In terms of applications, N-Demethyl rifampin is primarily utilized in scientific research rather than clinical settings. Researchers investigate its role in resistance modulation, metabolic pathways, and its impact on the efficacy of rifampin-based treatments. It serves as a crucial tool in understanding the complexities of antibiotic metabolism and developing improved strategies for combating bacterial infections.

Enoxacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandins and thromboxanes. It has been shown to be effective against infectious diseases caused by bacteria, protozoa, and fungi, including E. coli, Salmonella typhimurium, Giardia lamblia, Candida albicans, Trichophyton mentagrophytes, Microsporum canis and T. violaceum. Enoxacin's mechanism of action is not fully understood but it may inhibit the transcription of genes that code for proteins involved in inflammation or produce an inhibitory response element in the promoter region of these genes. This drug also has minimal toxicity to humans and low levels of drug interactions with other drugs when taken concurrently. Nitrite ion and human polymorphonuclear leukocytes (PMNL) are both important factors in enoxacin's mechanism of action as they activate the enzyme guanylate cyclase which

Applications (±)-Camphor, has a strong aromatic odor. It is toxic to insects so it can be used as repellent. Camphor can also be used as a plasticizer for nitrocellulose, as a moth repellent, and as an antimicrobial substance.This compound is a contaminant of emerging concern (CECs)EC Number: 200-945-0 Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Abdelgaleil, S.A.M. Appl. Entomol. Zool., 45, 425 (2010); Tabanca, N. et al.: J. Agric. Food. Chem., 49, 4300 (2001);

Rifamdin is an antibiotic, which is a chemical substance derived from the source compound rifampicin. Its mode of action involves the inhibition of bacterial DNA-dependent RNA polymerase, which effectively suppresses bacterial RNA synthesis, leading to cell death. This mechanism primarily targets Mycobacterium tuberculosis, the causative agent of tuberculosis. The uses and applications of Rifamdin are primarily in the treatment and management of tuberculosis infections. As a critical component of multi-drug regimens, it plays a vital role in reducing the bacterial load and preventing the development of drug resistance. Rifamdin’s effectiveness in penetrating cellular barriers also allows it to reach intracellular pathogens, making it suitable for addressing both active and latent tuberculosis infections. The use of Rifamdin, in combination with other antitubercular agents, continues to be pivotal in global tuberculosis control strategies, contributing significantly to the reduction of morbidity and mortality associated with the disease.

Iclaprim is an antibiotic, which is a synthetic diaminopyrimidine antimicrobial agent with a specific mechanism of action. It works by selectively inhibiting bacterial dihydrofolate reductase, a crucial enzyme in the bacterial folate synthesis pathway. This inhibition prevents the production of tetrahydrofolate, ultimately disrupting DNA, RNA, and protein synthesis in susceptible bacterial cells. The primary use of Iclaprim is in the treatment of acute bacterial infections, particularly skin and soft tissue infections caused by Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes. Its efficacy stems from its potent action against resistant bacterial strains, making it a valuable option in addressing antibiotic resistance challenges. Due to its mechanism, human cells remain unaffected, as they use a different pathway for folate synthesis, which underscores its selectivity and therapeutic potential. The development and application of Iclaprim offer significant insights into combating bacterial resistance and improving patient outcomes in clinical settings.

Doripenem is a carbapenem antibiotic with action on bacterial cell wall synthesis and is used for treating complicated bacterial infections like intra-abdominal infections and urinary tract infections.

Pefloxacin-d3 is a deuterated fluoroquinolone antibiotic, which is a synthetic derivative of pefloxacin utilized primarily for research purposes. This compound is chemically modified to include deuterium atoms, a stable isotope of hydrogen, thus offering unique properties essential for precise quantitative analysis in pharmacokinetic studies. The source of Pefloxacin-d3 is laboratory synthesis, where deuteration is applied to improve the compound's analytical characteristics, such as greater stability and differentiation in mass spectrometry. This enables enhanced tracking of the drug within biological systems, allowing scientists to gain a robust understanding of its absorption, distribution, metabolism, and excretion. Pefloxacin-d3 acts as an antibiotic by inhibiting DNA gyrase, an enzyme critical for bacterial DNA replication. This mechanism disrupts bacterial cell division and growth, making fluoroquinolones potent antimicrobials. In research contexts, Pefloxacin-d3 is pivotal in drug metabolism and pharmacokinetic modeling. By studying this compound, scientists can derive essential data on the pharmacological behavior of pefloxacin in vivo, facilitating the development of dosing strategies and the assessment of drug-drug interactions in clinical settings.

Biapenem is a carbapenem antibiotic and is used for the treatment of bacterial infections. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins.

Puromycin-D3 is a deuterium-labeled antibiotic, which is synthetically derived from the bacterium *Streptomyces alboniger*, with three hydrogen atoms replaced by deuterium. Its mode of action involves the inhibition of protein synthesis by mimicking the aminoacyl end of tRNA, causing premature chain termination during translation on ribosomes. This mechanism specifically targets growing peptides in cells, making it a valuable tool for studying protein synthesis. In scientific research, Puromycin-D3 is utilized in a variety of applications, including cell biology and molecular biology studies, where it serves as an essential component in experiments aiming to understand protein dynamics. The isotopic labeling with deuterium provides enhanced resolution in mass spectrometry, facilitating more accurate quantification and analysis of protein synthesis rates. Researchers employ Puromycin-D3 in experiments to investigate mechanisms of translational control and to monitor protein synthesis in vitro and in vivo, contributing to advances in understanding cellular processes and disease mechanisms.