Antimicrobianos

Piperaquine tetraphosphate tetrahydrate is an antimalarial compound with action on Plasmodium parasites by disrupting DNA synthesis and is used for treating malaria in combination therapies.

Troleandomycin is a macrolide antibiotic with action on bacterial protein synthesis by binding to the ribosome and is used for treating bacterial infections, particularly respiratory infections.

Oxfendazole is a benzimidazole anthelmintic with action on microtubule formation in parasitic worms and is used for treating gastrointestinal parasites in livestock.

Tautomycin is a natural compound classified as a polyketide, which is isolated from the bacterium *Streptomyces spiroverticillatus*. This bacterium is renowned for its ability to produce biologically active secondary metabolites with diverse pharmacological properties. Tautomycin is recognized for its mode of action as a potent inhibitor of protein phosphatases, specifically protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). These enzymes play critical roles in cellular processes by regulating phosphorylation states, which control various signaling pathways within the cell. By inhibiting PP1 and PP2A, tautomycin disrupts cellular signaling, offering valuable insights into understanding signal transduction mechanisms. This makes it a powerful tool in biochemical research, particularly in the study of cancer, where dysregulated phosphatase activity is often implicated. Furthermore, tautomycin's unique inhibitory profile provides a platform for developing novel therapeutic strategies aimed at modulating phosphatase activity. Its applications extend beyond cancer research, offering utility in neurobiology and other fields where phosphorylation-dephosphorylation cycles are critical to cell function and health.

Sordarin sodium salt is an antifungal agent, characterized as a semisynthetic derivative produced from the fermentation products of filamentous fungi, specifically belonging to the phylum Ascomycota. This compound exerts its effects by selectively inhibiting fungal protein synthesis. It achieves this by obstructing the function of elongation factor 2 (EF-2), an essential component of fungal ribosomal activity, thereby disrupting the translational elongation step of protein synthesis. The primary uses and applications of Sordarin sodium salt lie in the study of fungal infections and the development of antifungal therapies. Due to its specific mechanism of targeting fungal organisms without affecting human cells, it is a valuable tool in biochemical and pharmacological research. Scientists employ it to elucidate the molecular pathways involved in fungal growth and replication, providing insights that could lead to novel antifungal drug development. Its specificity and mode of action make it an important subject in research directed at combatting resistant strains of fungi, contributing to the broader field of infectious disease management.

Picloxydine digluconate is an antiseptic agent, which is derived from synthetic chemical processes designed to produce highly effective antimicrobial compounds. It operates through the disruption of microbial cell membranes, leading to the leakage of cell contents and subsequent cell death. This mode of action is particularly efficient against a wide spectrum of bacteria, including both Gram-positive and Gram-negative strains, as well as fungi and some viruses. Picloxydine digluconate is primarily used in medical and clinical settings for wound care and surgical site disinfection, as its broad-spectrum antimicrobial activity helps prevent infections in compromised tissue. Additionally, it is applied in various formulations for hand sanitization in healthcare environments, ensuring a high standard of hygiene and reducing the risk of nosocomial infections. This compound's stability and efficacy at low concentrations make it a valuable tool in infection control protocols, contributing significantly to patient safety and recovery outcomes in both acute and chronic care scenarios.

Sartorypyrone B is a secondary metabolite, which is isolated from certain fungal species, including those in the genus **Aspergillus**. This compound is part of a class of natural products known as polyketides, characterized by their diverse structural complexity and bioactivity. The mode of action of Sartorypyrone B involves the inhibition of microbial growth and disruption of cellular processes, making it a compound of interest in antibacterial and anticancer research. The uses and applications of Sartorypyrone B are primarily centered around its potential as a therapeutic agent. Its ability to impede the growth of various pathogenic bacteria opens avenues for the development of new antibacterial drugs. Furthermore, its action against cancer cell lines suggests its utility in anticancer drug development. Research continues to explore its full spectrum of biological activities, mechanisms of action, and potential for pharmaceutical exploitation. The focus remains on its synthesis, bioactivity studies, and understanding its interactions at the molecular level for possible future applications in medicine.

Pseudomonic acid F is a naturally occurring secondary metabolite, which is derived from the bacterium *Pseudomonas fluorescens*. Its mode of action involves the inhibition of bacterial protein synthesis by targeting the bacterial isoleucyl-tRNA synthetase enzyme. This inhibition disrupts the addition of isoleucine to the growing polypeptide chain, effectively impeding bacterial growth and proliferation. Pseudomonic acid F has garnered interest due to its potent antibacterial properties, making it a valuable compound for research into novel antibiotic therapies. Its specificity and efficacy against a broad range of Gram-positive bacteria, including resistant strains, underscore its potential in addressing antibiotic resistance challenges. Researchers are exploring its use in the development of new therapeutic agents that can be employed in clinical settings to treat infections that are unresponsive to conventional antibiotics. Additionally, its structural and functional attributes offer insights for synthetic modifications aimed at enhancing its pharmacokinetic properties and broadening its spectrum of activity.

Cytarabine is a pyrimidine nucleoside analogue that is used to treat leukaemia especially, non-lymphocytic leukaemia. This drug also has anti-viral and immunosuppressant properties. Cytarabine is cytotoxic and acts through direct DNA damage. Although its mechanism of action is not fully understood, it is said to inhibit DNA polymerase. Cytarabine hydrochloride is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Norfloxacin methyl ester is a synthetic derivative of the fluoroquinolone antibiotic, norfloxacin, which is sourced from chemical synthesis. Its mode of action involves inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication, transcription, repair, and recombination. This specific mechanism disrupts bacterial replication and cell division, leading to bacterial cell death. Norfloxacin methyl ester is primarily used in research and development settings to explore modifications to fluoroquinolone antibiotics and enhance pharmacokinetic profiles. It acts as a prodrug, potentially offering improved absorption and bioavailability over its parent compound, norfloxacin. Applications extend to preclinical studies for investigating antibacterial activity and resistance patterns. Researchers may utilize this compound to understand better the structural and functional aspects of fluoroquinolone interactions with bacterial targets.