Antimicrobianos

Ceftiofur is a third-generation cephalosporin antibiotic with action on bacterial cell wall synthesis and is used for treating bacterial infections in veterinary medicine.

Dimethenamid-ethane sulfonic acid (ESA) sodium is a herbicide metabolite, which is derived from Dimethenamid, an active ingredient in pre-emergent herbicides used for controlling grass and broadleaf weeds. The compound is formed through the metabolic degradation of the parent herbicide in soil and plants, largely influenced by microbial activity and environmental conditions. The mode of action of Dimethenamid-ethane sulfonic acid (ESA) sodium involves the inhibition of cell division by disrupting the synthesis of essential proteins necessary for weed growth. Through this mechanism, the product effectively restricts the development of emerging seedlings, thereby reducing competition with crops. Dimethenamid-ethane sulfonic acid (ESA) sodium is extensively used in agricultural research to assess the environmental behavior and persistence of herbicides. By studying its formation and degradation pathways, scientists can better understand the long-term impacts of Dimethenamid application on ecosystems, enabling more informed decisions regarding crop management and environmental protection. This research is essential for developing sustainable agricultural practices and ensuring the responsible use of herbicides.

Ethambutol 2HCl is a bacteriostatic antimycobacterial agent with action on arabinosyl transferases to inhibit cell wall synthesis and is used for treating tuberculosis in combination with other antibiotics.

Desmethyl ferroquine is an antimalarial compound, which is a derivative of ferroquine. It is synthesized through chemical modification processes, specifically designed to enhance its pharmacokinetic and pharmacodynamic properties. This compound exhibits its mode of action by compromising the integrity of the Plasmodium parasite's digestive vacuole. By doing so, it disrupts heme detoxification, which is crucial for the parasite’s survival within red blood cells. Desmethyl ferroquine is primarily utilized in research related to drug-resistant strains of malaria, offering insights into potential therapeutic approaches. Given the pressing challenge of resistance to widely used antimalarial drugs, Desmethyl ferroquine serves as a promising candidate in the development of next-generation antimalarial therapies. Researchers focus on its efficacy in various in vitro and in vivo studies to explore its potential applications further.

Neomycin is an antibiotic that inhibits the synthesis of proteins by binding to ribosomes and preventing the formation of peptide bonds. It has been shown to inhibit voltage-dependent calcium channels and polymerase chain reactions, which may be due to its ability to bind to RNA. Neomycin has also been used for a variety of metabolic disorders, including diabetes mellitus. This antibiotic is usually administered systemically, but it can also be used topically on skin infections. Neomycin is not active against bacteria that are resistant to other antibiotics such as penicillin or erythromycin.

Tenatoprazole sodium is a proton pump inhibitor, which is a synthetic pharmaceutical compound designed to selectively inhibit the hydrogen-potassium ATPase enzyme in the gastric parietal cells. This enzyme is essential for the final step of gastric acid production. Originating from organic chemical synthesis processes, Tenatoprazole sodium features a unique imidazopyridine structure, distinguishing it from other members of the proton pump inhibitor class such as omeprazole, which belongs to the benzimidazole family. In terms of its mode of action, Tenatoprazole sodium irreversibly binds to the cysteine residues present on the gastric proton pumps. This binding leads to the suppression of acid secretion in the stomach, providing a prolonged and potent effect compared to other similar agents. Consequently, it is employed in managing conditions like gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and peptic ulcers. Researchers are particularly interested in its long plasma half-life, which potentially offers improved dosing schedules and patient compliance. This makes Tenatoprazole sodium a significant subject in the ongoing development of therapies aimed at optimizing gastric acid-related disorder management.

Symetine is a synthetic peptide-based compound, which is a highly selective agonist of the adenosine A2A receptor. This receptor is coupled to G-proteins mainly associated with activating adenylate cyclase, leading to an increase in cyclic adenosine monophosphate (cAMP) levels within the cell. Symetine binds with high affinity to these receptors, inducing a conformational change that facilitates the downstream signaling pathways associated with this receptor family. The primary applications of Symetine are in the fields of neurobiology and cardiovascular research, where it serves as a tool to probe the physiological and pathophysiological roles of the adenosine A2A receptor. By selectively activating this receptor, researchers can delineate its role in modulating neurotransmission, neuroprotection, and inflammation. Moreover, due to its influence on cAMP levels, Symetine is also utilized in research focused on metabolic regulation and cellular energy homeostasis. Understanding the action of Symetine and its receptor may provide insights into various medical conditions, including neurodegenerative diseases, ischemic injuries, and inflammatory disorders.

2'-Deoxycoformycin is a potent adenosine deaminase inhibitor, which is derived from the fermentation of Streptomyces antibioticus, a species of actinomycete bacteria. This compound acts by specifically inhibiting the enzyme adenosine deaminase, leading to an accumulation of toxic deoxyadenosine triphosphate in lymphocytes. This buildup hinders DNA synthesis, effectively suppressing the proliferation of lymphoid cells. In clinical settings, 2'-Deoxycoformycin, also known as pentostatin, is used primarily in the treatment of certain types of cancer, such as hairy cell leukemia and chronic lymphocytic leukemia. Its mode of action makes it highly effective as a chemotherapeutic agent, particularly due to its ability to induce apoptosis in malignant cells. Researchers are also exploring its potential in treating autoimmune disorders, taking advantage of its immune-modulating properties. The specificity of 2'-Deoxycoformycin for adenosine deaminase makes it a valuable tool in both therapeutic applications and scientific research, highlighting its significance in biochemical studies and drug development.

9,11Beta-Dichloro-17,21-dihydroxy-16beta-methyl-pregna-1,4-diene-3,20-dione dipropionate is a synthetic corticosteroid, which is derived from chemical synthesis in laboratories. It functions by mimicking the actions of naturally occurring corticosteroids in the body, modulating immune responses and suppressing inflammatory mediators at the cellular level. The primary mode of action involves its interaction with specific glucocorticoid receptors, leading to the inhibition of pro-inflammatory cytokine production and the stabilization of lysosomal membranes. This results in decreased vascular permeability and reduced migration of leukocytes to sites of inflammation. This compound is extensively used in clinical settings to manage a variety of inflammatory and autoimmune conditions. It is applied in formulations for dermal, inhalation, or systemic administration, depending on the targeted application. Its efficacy in reducing symptoms of inflammation and allergy makes it valuable in managing diseases such as asthma, eczema, and arthritis. Careful dosing is crucial to minimize potential side effects associated with long-term corticosteroid use.

Antibiotic; used in selective media for P. aeruginosa

Stability Unstable in Aqueous Solution Applications Taurolidine-D6 is a labelled analogue of Taurolidine (T009050). Taurolidine is a derivative of the amino acid Taurine (T007850). Taurolidine exhibits antiendotoxin and antimicrobial activity, and has also been shown to exhibit antitumour activity in vitro and in vivo. Taurolidine is used for the treatment of sepsis and is utilized in hospitals to prevent catheter-related bloodstream infections. References Jurewitsch, B., et al.: J. Parent. Enter. Nut., 22, 242 (1998); McCourt, M., et al.: Ann. Surg. Oncol., 7, 685 (2000); Willatts, S., et al.: Crit. Care Med., 23, 1033 (1995)

Piperacillin sodium is a broad-spectrum beta-lactam antibiotic with action on bacterial cell wall synthesis and is used for treating severe infections caused by gram-negative bacteria, including Pseudomonas aeruginosa.

Saquinavir is a HIV protease inhibitor drug that is used with other antiretroviral drugs for the treatment of HIV-1. As this drug prevents HIV protease activity, it prevents the proteolysis of the Gag polyprotein and thus results in non-infectious virus particles. Saquinavir mesylate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Tigecycline mesylate is a novel glycylcycline antibiotic, which is a derivative of the tetracycline class of antibiotics. It is a semi-synthetic product derived from minocycline, exhibiting a broad spectrum of antibacterial activity. Tigecycline mesylate functions through the inhibition of bacterial protein synthesis. It achieves this by binding to the 30S ribosomal subunit, thereby preventing the incorporation of amino acid residues into elongating peptide chains, a crucial step in protein production. The primary use of Tigecycline mesylate lies in its effectiveness against multidrug-resistant (MDR) pathogens, including Gram-positive and Gram-negative bacteria, as well as certain anaerobes. Its applications extend to treating complicated skin and soft tissue infections, intra-abdominal infections, and community-acquired bacterial pneumonia. Due to its broad spectrum of activity and efficacy against resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA) and extended-spectrum beta-lactamase (ESBL)-producing organisms, it remains a significant option for combating antimicrobial resistance in clinical settings.