Antimicrobianos

Oxysanguinarine is an alkaloid compound, which is derived from the plant species of the Papaveraceae family. As a benzophenanthridine alkaloid, it is predominantly extracted from plants such as Sanguinaria canadensis. Its mode of action involves disrupting microbial cell membranes and interfering with enzyme systems, leading to antimicrobial and antifungal effects. This compound exhibits potential in inhibiting the growth of various pathogens, making it a subject of interest in pharmaceutical and microbiological research. Applications of oxysanguinarine extend to studying its efficacy in antimicrobial treatments, exploring its potential as a natural pesticide, and investigating its role in traditional medicine. Due to its complex biochemical interactions, ongoing research aims to better understand its mechanisms and potential therapeutic uses.

BIOSAFE® RTU Antimicrobial, 1% aqueous solution BIOSAFE® Antimicrobial is a non-leaching silicon-based antimicrobial that imparts bacteriostatic, fungistatic, and algistatic properties to coatings and resins for manufactured goods. 3-(Trihydroxysilyl)propyldimethyloctadecyl ammoniumchloride, 1% aqueous solution; 3-(Trihydroxysilyl)propyldimethyloctadecyl ammonium chloride; Octadecyldimethyl(3-trihydroxysilylpropyl)ammonium chloride, 84% active condensed; Silsesquioxanes, 3-(dimethyloctadecylammonio)propyl, hydroxy-terminated, chlorides EPA Registration Number: 83019-21% of HM4100 in waterUsed in water based surface treatments and coatingsMicrobiostatic agent that protects articles from deterioration and discolorationLeach resistantActive against forms of fungi, algae, and bacteriaHigh antimicrobial performance in ISO and ASTM testingDoes not promote development of resistant microorganismsIncompatible with anionic detergentsTypical use concentrations of 0.25-0.5 wt% active relative to the substrate being treated Water Based Surface Treatments CarpetNon-wovensRoll goodsBuilding materialsShoesIndoor environment surfaces

Silthiofam-des(trimethylsilyl) is a synthetic fungicidal compound, serving as a crucial component in the agricultural sector. It originates as a derivative from organic chemistry processes, designed to enhance the fungicide silthiofam by modifying its chemical structure to improve its stability and activity. The primary mode of action of Silthiofam-des(trimethylsilyl) involves disrupting the cellular processes of fungal pathogens, especially those that reside in the soil. This disruption is achieved through the inhibition of specific enzymes critical for fungal growth and development, making it an effective solution against pathogens such as those causing take-all disease in cereals. In scientific research and practical applications, Silthiofam-des(trimethylsilyl) is extensively utilized in the protection of crops, significantly wheat and barley, where soil-borne diseases are prevalent. Its usage is a vital component of integrated pest management strategies, aiming to enhance crop yield and health. As with any specialized compound, proper handling and application are essential to maximize efficacy and minimize any environmental impact.

Fosmanogepix is a novel antifungal prodrug, which is derived from manogepix. This product is a synthetic compound, designed to target invasive fungal infections through its unique mechanism of action. The prodrug itself is inactive until metabolized in the body, where it converts into its active form, manogepix. This activation occurs through enzymatic hydrolysis, enabling it to exert its antifungal effects. The mode of action of fosmanogepix involves the inhibition of the fungal enzyme Gwt1, which is crucial for glycosylphosphatidylinositol (GPI)-anchored protein maturation. This disruption in GPI-anchored proteins, which play a vital role in fungal cell wall integrity and virulence, leads to the impairment of fungal growth and replication. This targeted mechanism differentiates it from other antifungal agents, offering potential efficacy against a broader range of fungal pathogens, including strains resistant to conventional treatments. Fosmanogepix holds promise in the treatment of severe, systemic fungal infections, particularly in immunocompromised patients. Its broad-spectrum antifungal activity and unique mechanism provide a significant advancement in combating multidrug-resistant fungal pathogens. Further clinical evaluations are ongoing to establish its safety profile and efficacy across various fungal species.

Inhibits chaperone protein HSP90; anti-proliferative; antineoplastic

Amicoumacin A is an antibiotic compound, which is derived from the bacterium Bacillus subtilis. This natural source is known for its production of a variety of biologically active compounds that contribute to its utility in numerous scientific contexts. The mode of action of Amicoumacin A involves the inhibition of bacterial protein synthesis by targeting the ribosomal subunit. Specifically, it interferes with the translation process, effectively disrupting the growth and proliferation of susceptible bacterial strains. Amicoumacin A is primarily utilized in research settings to study bacterial resistance mechanisms, as well as to explore novel antibacterial therapies. Its application in scientific research extends to examining its potential synergistic effects with other antimicrobial agents, and it serves as a model compound for understanding ribosomal inhibition. The study of Amicoumacin A not only contributes to the broader field of antibiotic development but also offers insights into the molecular interactions that underlie bacterial protein synthesis and antibiotic resistance. This compound's unique properties make it an important subject of investigation for microbiologists and pharmacologists alike, emphasizing its relevance in the ongoing battle against antibiotic-resistant pathogens.

Stability Moisture Sensitive Applications 3,6-Dichlorophthalic Anhydride is an intermediate in the synthesis of phthalic compounds, phthalazines, and quinones with antimicrobial activity. References Hansongnern, K., et al. Appl. Magnetic. Resonance., 23, 333 (2003);

1,4-Dihydro-2,3-benzodithiine is a synthetic organic compound, which is often utilized in the field of material science and chemical research. It is derived from aromatic dithiins, characterized by a unique heterocyclic structure containing sulfur atoms within its ring system. The compound’s mode of action primarily involves its ability to partake in various cycloaddition reactions due to the electron-rich nature of the dithiine ring, which can facilitate interactions with electrophiles. In terms of its applications, 1,4-Dihydro-2,3-benzodithiine is valuable in the synthesis of advanced materials, particularly those requiring specific electronic properties. It serves as a precursor in the development of polymers and organic electronic materials, where its chemical stability and electronic characteristics are highly sought after. Additionally, this compound is pivotal in research areas exploring new synthesis methodologies and reaction mechanisms, providing insights into the behavior of sulfur-containing heterocycles.

Applications (+)-Phytone is an constituent of leaf essential oil of Lawsonia Inermis growing in Nepal with potential anti-microbial activities. References Satyal, P., et al.: Pharmacol., 1, 31 (2012);

Tenofovir is an acyclic nucleoside phosphonate that exhibits anti-viral properties through its inhibition of reverse transcriptases. In particular, Tenofovir is a potent inhibitor of Human Immunodeficiency Virus (HIV) and chronic Hepatitis B Virus (HBV) reverse transcriptases, thus preventing the replication of genetic viral material. This property is beneficial in virus research areas and developing antiviral treatments. Once inside the body tenofovir is metabolized into its active form, tenofovir diphosphate, by the lysosomal protease cathepsin A, nucleotide kinases and adenylate kinases.  Tenofovir is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Geneticin is very efficient against gram-negative bacteria, however it is not applied for treating infections due to high renal toxicity. Geneticin and its resistance genes found application in the selection of transgenic cell lines including yeasts such as P. pastoris and S. serevisiae, other eukaryotic cell lines such as CHO or HEK293, but also plant cells and bacterial cells.

STAADIUM™ PeptiZide L-Ala is a targeted inhibitor for L-alanine aminopeptidase-producing bacteria. The antibacterial activity of STAADIUM™ PeptiZide L-Ala is triggered by the enzyme L-alanine aminopeptidase, an enzyme located in the bacterial cell wall and is a characteristic of Gram-negative bacteria. L-alanine aminopeptidase has not been experimentally detected in Campylobacter species, anaerobic bacilli, Gram-positive and Gram-variable bacteria. More details in the application notes document.

Capastat sulfate is an antibiotic with action against Mycobacterium tuberculosis by inhibiting protein synthesis and is used for treating tuberculosis.

Levomekol is a topical antibiotic ointment, which is a synthesized pharmaceutical product with antibacterial and anti-inflammatory properties. It contains chloramphenicol, a broad-spectrum antibiotic, and methyluracil, which promotes tissue repair and regeneration. The mode of action involves the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, effectively curbing bacterial growth and proliferation. Concurrently, methyluracil stimulates leukocyte activity and enhances the healing process by promoting cellular regeneration and collagen production. Levomekol is primarily used for the treatment of infected wounds, burns, and ulcers. Its application is particularly beneficial in environments where sterility and infection control are paramount. The ointment is applied directly to the affected area, where it exerts both antimicrobial and reparative effects. Its dual functionality makes it a valuable tool in clinical settings for managing both the prevention of infection and the acceleration of wound healing. Through its targeted action, Levomekol effectively manages infection and inflammation, facilitating the restoration of damaged tissues.