Antiparasitarios
Los antiparasitarios son compuestos diseñados para tratar y prevenir infecciones parasitarias mediante la inhibición del crecimiento y la supervivencia de los parásitos. Esta categoría incluye una variedad de agentes antiparasitarios destinados exclusivamente para uso en laboratorio y no para el consumo humano. Estos productos son esenciales para fines de investigación, permitiendo a los científicos estudiar los ciclos de vida de los parásitos, los mecanismos de acción y el desarrollo de resistencia. El uso de antiparasitarios en entornos de laboratorio ayuda en el descubrimiento y la optimización de nuevos tratamientos para enfermedades parasitarias, contribuyendo a los avances en parasitología médica y veterinaria. Los investigadores dependen de estos productos para mejorar su comprensión de las infecciones parasitarias y desarrollar terapias más efectivas.
Productos de "Antiparasitarios"
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(2R,3R)-Benzhydryl 2,3-bis(benzyloxy)-4-hydroxybutanoate
Producto controladoApplications (2R,3R)-Benzhydryl 2,3-bis(benzyloxy)-4-hydroxybutanoate is an intermediate in synthesizing 4-Phospho D-Erythronate (P355000), which is an intermediate in the synthesis of pyridoxal 5'-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Phosphorylated aldonic acids are strong inhibitors of 6-phosphogluconate dehydrogenase, and 4-phospho-D-erythronate (4PE) and 4-phospho-D-erythronohydroxamate are two of the strongest inhibitors of the Trypanosoma brucei enzyme. References Tanaka, N., et al.: J. Mol. Biol., 324, 519 (2002); Fitzpatrick, T., et al.: Biochem. J., 407, 1 (2007); Kalliri, E., et al.: J. Bacteriol., 190, 3793 (2008)Fórmula:C31H30O5Forma y color:NeatPeso molecular:482.567Insecticidal agent 16
CAS:Insecticidal agent 16 (compound A21) exhibits insecticidal activity against Plutella xylostella, with LC50 values of 1.2 and 13.2 µg/mL respectively.Fórmula:C21H13Cl2F6N5O2SForma y color:SolidPeso molecular:584.32Ac-Atovaquone
CAS:Ac-Atovaquone, an ester-acetylated derivative of atovaquone, acts as a potent inhibitor of cytochrome bc1 (cytochrome bc1). This compound shows potential for use in malaria research.Fórmula:C24H21ClO4Forma y color:SolidPeso molecular:408.87Bacopasaponin C
CAS:Bacopasaponin C may have antioxidant activity, it also shows anti-leishmanial property.Fórmula:C46H74O17Pureza:97.85%Forma y color:SolidPeso molecular:899.074-Amino-1-pentanol-d4 Benzyl Ether
Producto controladoApplications 4-Amino-1-pentanol-d4 Benzyl Ether is an intermediate in the synthesis of Hydroxychloroquine-d4 Sulfate (H916902), which is an antimalarial; antirheumatic; lupus erythematosus suppressant. References Yarden, Y., et al.: Nature, 323, 226 (1986), Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989), Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002), Card, J., et al.: Toxicol. Sci., 75, 169 (2003),Fórmula:C12D4H13NO2Forma y color:NeatPeso molecular:211.293Piperaquine-d6 Tetraphosphate
CAS:Producto controladoApplications Piperaquine-d6, is a 4-aminoquinoline derivative used as an antimalarial agent. Piperaquine interferes with physiological function of the food vacuole membrane of the trophozoites leading to autophagocytosis of the parasites. It is commonly used in combination with Dihydroartemisinin (D448360) for the treatment of multi-drug resistant falciparum malaria. References Nguyen, T.M.T. et al.: Tap Chi Duoc Hoc, 57, 22 (2007); Song, J. et al.: Malaria J., 10, 231 (2011);Fórmula:C29H26D6Cl2N6•4H3PO4Forma y color:NeatPeso molecular:933.53Halofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Fórmula:C16H17BrClN3O3Pureza:97.67%Forma y color:Off-White SolidPeso molecular:414.685-(N-Ethyl-N-2-hydroxyethylamino)-2-penthlamine
CAS:Producto controladoApplications 5-(N-Ethyl-N-2-hydroxyethylamino)-2-penthlamine is a useful synthetic intermediate in the synthesis of Hydroxy Chloroquine (H905300/H905305); a major metabolite of Chloroquine (C379965, diphosphate salt) which is a standard anti-malarial drug. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Brocks, D., et al.: Clin. Pharmacokinet., 42, 1359 (2003); Brocks, D., et al.: Clin. Pharmacokinet., 42, 1359 (2003); Huang, S., et al.: Talanta, 64, 887 (2004); Luthman, H., et al.: Nucleic Acids Res., 11, 1295 (1983); Vezmar, M., et al.: Biochem. Pharmacol., 56, 733 (1998); Krajewski, W.A., et al.: J. Biomol. Struct. Dyn., 16, 1097 (1999)Fórmula:C11H26N2OForma y color:NeatPeso molecular:202.337cis-Atovaquone-d5 (contains 10% trans isomer)
CAS:Producto controladoApplications Cis isomer of Atovaquone-d5.Fórmula:C22H14D5ClO3Forma y color:NeatPeso molecular:371.87trans-Clopenthixol dihydrochloride
CAS:Trans-Clopenthixol dihydrochloride ((E)-Clopenthixol dihydrochloride), an antibiotic without neuroleptic effects, has demonstrated in vitro efficacy against Pseudomonas aeruginosa and Plasmodium falciparum, as referenced in [1] [2].Fórmula:C22H27Cl3N2OSPureza:98%Forma y color:SolidPeso molecular:473.89Atherosperminine
CAS:Atherosperminine inhibits AChE/BChE and relaxes trachealis via cAMP phosphodiesterase inhibition.Fórmula:C20H23NO2Pureza:99.4%Forma y color:SolidPeso molecular:309.4Piperonyl butoxide
CAS:Piperonyl butoxide (Pyrenone 606) is an insecticide synergist, particularly for rotenone and pyrethroids.Fórmula:C19H30O5Pureza:99.84%Forma y color:Pale Yellow Liquid Oil LiquidPeso molecular:338.44Antileishmanial agent-21
Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism.Fórmula:C21H16N2O3Pureza:98%Forma y color:SolidPeso molecular:344.36UCB7362
CAS:UCB7362 (GLXC-26743) is an orally available and potent plasmepsin X (PMX) inhibitor with anti-malarial activity.UCB7362 inhibits parasite reproduction.Fórmula:C25H26ClN5O3Pureza:97.38%Forma y color:SolidPeso molecular:479.963-Aminopropionitrile (Stabilized with K2CO3)
CAS:Producto controladoFórmula:C3H6N2Forma y color:NeatPeso molecular:70.09Eflornithine
CAS:Eflornithine blocks ornithine decarboxylase, treating African trypanosomiasis and female facial hair.Fórmula:C6H12F2N2O2Pureza:99.44% - 99.84%Forma y color:SolidPeso molecular:182.17Antileishmanial agent-20
Antileishmanial agent-20 exhibits selectivity against the Leishmania parasite, with IC50 values of 2.8 μM for L.Fórmula:C15H16N4O3Pureza:98%Forma y color:SolidPeso molecular:300.31Miltefosine
CAS:Fórmula:C21H46NO4PPureza:>98.0%(T)(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:407.58Kojic acid
CAS:Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 μM for mushroom tyrosinase.Fórmula:C6H6O4Pureza:99.34% - 99.72%Forma y color:Prismatic Needles From Acetone Ethanol+Ether Or Methanol+Ethyl Acetate Tan PowderPeso molecular:142.11
