Fuente botánica

Benzoylmesaconine (BEN, an aconitine derivative extracted from heated-Aconiti tuber) induces the generation of CD4+ T cells antagonistic to type 2 T cells (BEN-CD4+ T cells), the combination therapy of IL-12 (an inducer of type 1 T cell responses) and BEN (an inhibitor of type 2 T cell responses) may protect TI-mice from severe HSV-1 infection.

Gypenoside XLIX is a saponin compound, which is derived from the plant Gynostemma pentaphyllum, commonly known as Jiaogulan. This plant is a valuable source of various gypenosides, which are structurally similar to ginsenosides found in ginseng. Gypenoside XLIX acts primarily through modulating cellular pathways, including antioxidative, anti-inflammatory, and apoptotic processes. It interacts with cell signaling mechanisms, potentially influencing metabolic and cardiovascular health. Gypenoside XLIX is being studied for its wide-ranging pharmacological applications. Research has shown that it may possess neuroprotective and cardioprotective effects, making it a focus in studies related to neurodegenerative diseases and myocardial ischemia. Additionally, its role in enhancing immune function and promoting cellular homeostasis opens avenues for further exploration in cancer research. While studies are ongoing, its multifaceted actions suggest potential in therapeutic interventions and preventative healthcare strategies.

Mycothiol (MSH or AcCys-GlcN-Ins) is an unusual thiol compound found in the Actinobacteria. It is composed of a cysteine residue with an acetylated amino group linked to glucosamine, which is then linked to inositol. The oxidized, disulfide form of mycothiol (MSSM) is called mycothione, and is reduced to mycothiol by the flavoprotein mycothione reductase. Mycothiol biosynthesis and mycothiol-dependent enzymes such as mycothiol-dependent formaldehyde dehydrogenase and mycothione reductase have been proposed to be good drug targets for the development of treatments for tuberculosis. This material is provided as a solid in dried buffer improve stability. MSH can readily be prepared from MSSM. Due to the rapid oxidation of MSH to MSSM, only MSSM can be shipped.

Narirutin has anti-inflammatory effect in a murine model of allergic eosinophilic airway inflammation, the mechanism is likely to be associated with a reduction in the OVA-induced increases of IL-4 and IgE, suggests that narirutin may be an effective new tool in the treatment of bronchial asthma.

Angoroside C has anti-inflammatory effect , it can significantly inhibit LPS-induced PGE(2), NO and TNF-alpha in a concentration-dependent manner; it also exhibits cytotoxic and cytostatic activities against several kinds of cancer cells. Angoroside C has beneficial effects against ventricular remodeling, the mechanism is likely to be related to decreasing the level of Ang Ⅱ, attenuating the mRNA expressions of ET-1 and TGF-β1.

Memantine lactose adduct is a synthetic pharmaceutical compound, which is derived from memantine, a well-known NMDA receptor antagonist, conjugated with lactose. This compound is sourced through chemical synthesis processes that aim to explore alternative formulations and derivatives of memantine to enhance delivery and bioavailability. Memantine acts by blocking the NMDA receptor in the central nervous system, which can prevent excitotoxicity caused by overactivation of glutamate neurotransmission. The conjugation with lactose is hypothesized to facilitate improved pharmacokinetic properties, potentially allowing for better absorption or controlled release. In scientific settings, memantine lactose adduct is primarily researched for its potential applications in treating neurological conditions such as Alzheimer's disease and other cognitive disorders that involve excitotoxic neuronal damage. Researchers are particularly interested in its capacity to provide neuroprotective effects, making it a subject of ongoing preclinical and clinical studies aimed at advancing therapeutic options in neuropharmacology.