Fuente botánica

Formononetin 7-O-glucoside-6''-O-malonate is a naturally occurring flavonoid compound, which is often derived from various plant sources, particularly those in the legume family. It is a malonylated glucoside derivative of formononetin, a well-known isoflavone. This compound plays a significant role in the plants' defense mechanisms and contributes to their physiological processes. The mode of action of Formononetin 7-O-glucoside-6''-O-malonate largely centers around its potential antioxidant and anti-inflammatory properties. By interacting with cellular pathways, it can modulate the activity of enzymes and receptors involved in oxidative stress and inflammation, thereby exhibiting potential protective effects against cellular damage. In scientific research, Formononetin 7-O-glucoside-6''-O-malonate is studied for its potential applications in promoting human health. Its antioxidant capabilities suggest a role in protecting cells from oxidative stress, while its anti-inflammatory properties may have implications in the management of inflammatory conditions. Further investigation is ongoing to fully elucidate its range of biological activities and potential therapeutic applications.

Liensinine is a human ether-a-go-go-related gene (hERG) inhibitor and a novel autophagy/mitophagy inhibitor, which can antagonize the ventricular arrhythmias. It exerts remarkable effect against thrombosis and possesses strong effect against platelet aggregation and coagulation.

Nomilin has immunomodulatory, antioxidant, anti-human immunodeficiency virus(HIV), cancer chemopreventive, antiangiogenic, anti-obesity and anti-hyperglycemic effects. Nomilin inhibits tumor-specific angiogenesis by downregulating VEGF, NO and proinflammatory cytokine profile and also by inhibiting the activation of MMP-2 and MMP-9. It inhibits osteoclastogenesis in vitro by suppression of NFATc1 and MAPK signaling pathways, indicates that nomilin-containing herbal preparations have potential utility for the prevention of bone metabolic diseases.

Linarin is a flavone glycoside in the plants Flos chrysanthemi indici, Buddleja officinalis, Cirsium setosum, Mentha arvensis and Buddleja davidii, possesses analgesic, antipyretic, anti-inflammatory and neuroprotective activities.

(R)-Ginsenoside Rg2 is a naturally occurring bioactive compound derived from the roots of the Panax ginseng plant. It is classified as a saponin, known for its significant pharmacological potential. The source of (R)-Ginsenoside Rg2 lies in the ginsenosides, specific triterpenoid saponins found in ginseng, which have been extensively studied for their health-promoting properties. The mode of action of (R)-Ginsenoside Rg2 involves numerous biochemical pathways, including modulation of signaling pathways associated with antioxidative and anti-inflammatory effects. It has the capability to influence neuroprotective activities and can alter the expression of various genes related to neurological functions and immune response. Applications of (R)-Ginsenoside Rg2 are diverse, primarily due to its therapeutic potential. It has been investigated for its role in enhancing cognitive functions, providing neuroprotection, and supporting cardiovascular health. Its use in research is particularly focused on understanding its effects on central nervous systems and its potential as a treatment in neurodegenerative diseases. This makes (R)-Ginsenoside Rg2 an intriguing subject in pharmacological and clinical studies, bringing forth its potential contributions to future therapeutic developments.

20-(S)-Ginsenoside F2 is a bioactive compound isolated from the roots of Panax ginseng, a plant renowned for its diverse pharmacological properties. As a saponin glycoside, it is derived through the enzymatic hydrolysis of major ginsenosides like Rb1. The compound functions primarily through modulating various cellular pathways, including apoptosis, autophagy, and inflammation via its interaction with membrane receptors and intracellular signaling molecules. The compound has demonstrated potential in the fields of oncology, cardiovascular health, and neuroprotection. Its anti-cancer effects are notable, achieved by inducing apoptosis in cancer cells and inhibiting metastatic pathways. Additionally, 20-(S)-Ginsenoside F2 exhibits cardioprotective properties through its antioxidative action and modulation of lipid metabolism. In neurological applications, it offers neuroprotective benefits, potentially ameliorating neurodegenerative disorders through attenuation of oxidative stress and neuroinflammation. These multifaceted mechanisms render 20-(S)-Ginsenoside F2 a subject of significant interest in the development of novel therapeutic agents, particularly due to its natural derivation and potential for minimal adverse effects compared to synthetic pharmaceuticals.

Spirosolane-type steroidal alkaloid glycoside found in ripe cherry tomato

Vitexicarpin has shown antitumor, cytotoxicity, anti-inflammatory, analgesic and immunoregulatory properties.Vitexicarpin can act as a novel angiogenesis inhibitor, it exerts good antiangiogenic effects by inhibiting vascular-endothelial-growth-factor-(VEGF-) induced endothelial cell proliferation, migration, and capillary-like tube formation on matrigel in a dose-dependent manner. It can significantly reduce vascular inflammation, through inhibition of ROS-NF-κB pathway in vascular endothelial cells.

gamma-Mangostin is a dual agonist that activates both PPARδ and PPARα, is also a novel competitive antagonist for the 5-HT2A receptors in vascular smooth muscles and platelets.gamma-Mangostin has free radical scavenging activity, and antiproliferative and apoptotic activity in HepG2 cells, and exhibits antihypertensive, anti-inflammatory, analgesic effects. gamma-Mangostin could as a preventive agent of the metabolic syndrome, and could serve as a micronutrient for colon cancer prevention.