Estándares de hidrocarburos aromáticos policíclicos (PAH)

Applications Benzo[a]pyrene-d12 is deuterium labelled and a useful compound for determining polycyclic aromatic hydrocarbons in cigarette mainstream smoke. It can also be used to prepare isotope internal standard solutions suitable for analyzing polycyclic aromatic compounds from complex mixtures in mass spectrometry. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Wang, X., et al.: Faming Zhuanli Shenqing CN 103439443 A 20131211 (2013); Sim, P. G., et al.: Polycyclic Aromat. Compd 3, 55 (1993)

Applications A medicinal, prophylactic additive in animal feeds, protecting poultry from histomoniasis.Environmental contaminants; Food contaminants; Heat processing contaminants References Kowalski, P., et al.: J. Pharm. Biomed. Anal., 32, 937 (2003), Khlebnikov, A., et al.: Bioorg. Med. Chem., 16, 9302 (2008), Schepetkin, I., et al.: Mol. Pharmacol., 74, 392 (2008),

Applications Phenanthrene is a polycyclic aromatic hydrocarbons, an environmental pollutant.This compound is a contaminant of emerging concern (CECs). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Di Toro, D. et al.: Environ. Toxicol. Chem., 19, 1971 (2000); Vines, C. et al.: Aquat. Toxicol., 51, 225 (2000); Incardona, J. et al.: Toxicol. Appl. Pharmacol., 196, 191 (2004); Junghans, M. et al.: Aquat. Toxicol., 76, 93 (2006);

Applications 1,6-Dichloropyrene is a chlorinated polycyclic aromatic hydrocarbon found in air samples from the urban environment. References Oestman, C., et al.: J. High Res. Chromatog., 15, 745 (1992)

Applications 6-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. This is the labeled analog. References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999);

Applications Dibenzo[b,def]chrysene is a carcinogenic, polycyclic aromatic hydrocarbon whose derivatives have the ability to deliver high-power-conversion efficiencies in bulk heterojunction solar cells. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Winzenberg, K., et al.: Chem. Mater., 21, 5701 (2009)

Applications 1-Methylpyrene is a fluorescent probe useful for micellar aggregation number. References Malliaris, Angelos., et al.: J. Chem. Soc. 82, 109 (1986); Boens, N., et al.: Chemical Physics Letters, 146, 337 (1988);

Applications 1-Nitropyrene is the most abundant nitropolycylcic aromatic hydrocarbon found in exhaust from diesel engines with potent carcinogenic and mutagenic properties. References Arce, R., et al.: J. Phys. Chem. A., 112, 10294 (2008);

Applications 1-Methylfluoranthene is an environmental pollutant that has been found to be a mutagen. References Wise, S.A., et. al.: Environ. Int., 11, 147 (1985)

Applications 5-Methylbenz[a]anthracene is a monomethylated polycyclic aromatic hydrocarbon with carcinogenic activity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Majumdar, R. et al.: Mutat. Res. Lett., 175, 1 (1986); Smith, I.A. et al.: Int. J. Quant. Chem. Quant. Biol. Symp., 5, 311 (1978); Wislocki, P.G. et al.: Carcinogenesis, 3, 215 (1982);

Applications A major metabolite of 2-nitrofluorene (NF). It exhibits a significant estrogenic activity. References Stresser, D., et al.: Drug Metab. Dispos., 26, 868 (1998), Charles, G., et al.: Toxicol. Sci., 55, 320 (2000), Raichurkar, A., et al.: J. Med. Chem., 46, 4419 (2003).

Applications 2,7-Diisopropylnaphthalene (cas# 40458-98-8) is a useful research chemical. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 6-Methylquinoline, is a building block used for the synthesis of various pharmaceutical compounds, and biologically active compounds. It can be used for the preparation of pyranobenzopyrone compounds, having anti-norovirus activity. References Pokhrel, L., et al.: bioorg. Med. Chem. Lett., 22, 3480 (2012);

Applications 2-Methylnaphthalene-D10 is a labelled analogue of 2-Methylnaphthalene (M323130). 2-​Methylnaphthalene is a polycyclic aromatic hydrocarbon (PAH) that has been used as an indicator of smoke exposure in food and packaging materials. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Johnston, J.J., et. al.: J. Agr. Food Chem., 42, 1954 (1994)

Applications 3-Chloroacenaphthene is a chloro derivative of Acenaphthene (D448330); a polycyclic aromatic hydrocarbon serving as a carcinogenic agent. References Hansen, B., et al.: Environ. Toxicol. Chem., 18, 772 (1999); Czub, G., et al.: Environ. Sci. Technol., 38, 2406 (2004)

Applications 6-Nitrochrysene-d11 is an isotopically labelled form of 6-Nitrochrysene(N520220). 6-Nitrochrysene is a nitro-polycyclic aromatic hydrocarbon and a carcinogen selector. An environmental contaminant and a carcinogen. References Hu, S., et al.: J. Air Waste Manag. Assoc., 63, 984 (2013); Boyiri T., et al.: Carcinogenesis, 25, 637 (2004); Krieger, R. K., et al.:Proceedings, Annual Meeting - Air & Waste Management Association, 90, WP100A06 (1997);

Applications 3-Hydroxy Benzopyrene O-β-D-glucuronide is the glucuronide conjugate and metabolite of the carcinogen Benzopyrene (B205800). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bevan, D.R. et al.: Carcinogensis, 13, 403 (1992); Nishimoto, M. et al.: Xenobiotica, 22, 949 (1992);Zheng, Z. et al.: Drug Metab. Dispos., 30,397 (2002);

Applications Octachloronapthalene is a polychlorinated napththalene (PCN) produced via industrial thermal processes. It is a chemical pollutant present in the environment. References Liu, G. et al.: Chemos., 118, 112 (2015); Pena-Abaurrea, M. et al.: Env. Sci. Tech., 48, 9591 (2014);

Applications Dibenzo[a,i]pyrene is a polycyclic aromatic hydrocarbon (PAH) with potent carcinogenic activity. Dibenzo[a,i]pyrene was shown to induce DNA adduction, tumorigenicity as well as Ki-ras oncogene mutations in strain A/J mouse lung. Dibenzo[a,i]pyrene has been shown to be present in cigarette smoke condensate and in automobile exhaust gas in small quantities. References Prahalad, A.K. et al.: Carcinogenesis, 18, 1955 (1997); Wynder, E.L. et al.: Nature, 192, 1092 (1961); Homburger, F. et al.: J. Nat. Cancer Inst., 44, 357 (1970);

Applications A 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Particularly used in the treatment of Mycoplasma infection. References Osono, T. et al.: J. Antibiot., 27, 366 (1974); Kuriaki, K. et al.: Jpn. J. Antibiot., 22, 232 (1969); Tan K. et al.: Zhonghua Yiyuamganranxue Zazhi, 16, 235 (2006);

Applications A metabolite of Benzopyrene (BaP), a carcinogenic component of tobacco smoke implicated in lung cancer. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References DiBiasio, K., et al.: Drug Metab. Dispos.,19, 227 (1991), Beach, J., et al.: J. Anal. Toxicol., 24, 670 (2000), Borman, S., et al.: Toxicol. Appl. Pharmacol., 167, 191 (2000), Tsai-Turton, M., et al.: Biol. Reprod., 77, 442 (2007),

Applications Phenanthrene derivative used to make fluorescent probes. References Panda, G., et al.: Bioorg. Med. Chem., 12, 5269 (2004), Panda, G., et al.: Eur. J. Med. Chem., 42, 410 (2007), Nakagawa-Goto, K., et al.: J. Med. Chem., 51, 3297 (2008),

Applications Mono[2-(perfluorohexyl)ethyl] phosphate is used to water- and grease-proof food packaging materials, and this chemical is a known precursor to perfluoroalkyl carboxylic acids (PFCAs) References Gebbink, Wouter A., Envir. Sci. and Pollution Res., 20(11), 7949-7958 (2013)

Applications 8-Hydroxybentazone, is a metabolite of Bentazon, a selective post-emergence herbicide. References Kim, J., et al.: ACS Symp. Series, 899, 92 (2005); Roper, J., et al.: Wat. Res., 29, 2720 (1995);

Applications 9,10-Dichlorophenanthrene is a chlorinated polycyclic aromatic hydrocarbon (Cl-PAH) found in the urban environment, known to display dioxin-like toxicity and mutagenicity. References Ma, J., et al.: Adv. Mat. Res., 610, 2989 (2013); Ma, J., et al.: Environ. Sci. Technol., 43, 643 (2009)

Applications trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene (B205800). Benzo[a]pyrene (B205800), a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene (D452280) undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2'-deoxyguanosine. A carcinogen. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Gelhaus, S. et al: Chem. Res. Toxicol., 24, 89 (2011); Belvedere, G. et al.: Biochem. Pharmacol., 29, 1693 (1980); Jennette, K. et al.: Biochem. Pharmacol., 28, 338 (1979); Yagi, H. et al.: J. Am. Chem. Soc., 99, 2358 (1977)

Applications Perylene has been used as an acceptor for pristine C70 to be used as a sensitizer for efficient triplet-triplet annihilation upconversion; which has shown improved stability under continuous laser irradiation compared to the benchmark Pt(II)-ocetaethylprphyrin. Perylene has also been used as a dopant representing blue fluorescent dye on a white-emitting polymer film. Dyes and metabolites. References Moor, K., et. al.: Chem. Commun., 49, 10829 (2013); Sakai, K., et. al.: J. Mater. Chem-C, 1, 7866 (2013)

Applications 6-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999);

Applications A metabolite of polycyclic aromatic hydrocarbons in humans. References Jacob, J., et al.: Xenobiotica, 12, 45 (1982), Becher, G., et al.: Cancer Lett., 17, 301 (1983), Hoffmann, D., et al.: Cancer Treat. Res., 72, 1 (1995), Einolf, H., et al.: Chem. Res. Toxicol., 10, 609 (1997),

Applications Benzo[a]fluoren-11-one is a polycyclic aromatic hydrocarbon that has potential carcinogenic properties. It is a common organic substance found in aerosols, atmospheric air and gasoline exhausts. References Bekki, K., et al.: J. Health Sci., 55, 601 (2009); Moeller, M., et al.: Mutat. Res. Gen. Toxicol. Test., 157, 149 (1985); Simoneit, B., et al.: Atmos. Env. A. Gen. Topic., 25A, 2111 (1991); Yu, M. & Hites, R.: Anal. Chem., 53, 951 (1981)