EGFR
Les inhibiteurs du récepteur du facteur de croissance épidermique (EGFR) sont des composés qui bloquent la signalisation de l'EGFR, un récepteur souvent surexprimé dans divers cancers et qui joue un rôle crucial dans l'angiogenèse. Les inhibiteurs de l'EGFR sont utilisés pour prévenir la croissance tumorale et les métastases en perturbant les voies qui favorisent la formation de vaisseaux sanguins dans les tumeurs. Ces inhibiteurs sont largement utilisés dans la recherche et le traitement du cancer. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de l'EGFR de haute qualité pour soutenir vos recherches en oncologie et angiogenèse.
Produits appartenant à la catégorie "EGFR"
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Tyrphostin AG 879
CAS :Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.Formule :C18H24N2OSDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :316.46Desmethyl Erlotinib hydrochloride
CAS :Desmethyl Erlotinib hydrochloride (OSI 420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor.Formule :C21H21N3O4·HClDegré de pureté :99.49%Couleur et forme :SolidMasse moléculaire :415.87Ref: TM-T6619
1mg59,00€2mg84,00€5mg115,00€10mg188,00€25mg335,00€50mg505,00€100mg720,00€1mL*10mM (DMSO)127,00€PROTAC EGFR degrader 8
CAS :PROTAC EGFR degrader 8 (T-184) is a PROTAC that selectively degrades the epidermal growth factor receptor (EGFR) with a DC50 of 15.56 nM in HCC827 cells.Formule :C40H46ClN11O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :796.32lavendustin A
CAS :lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.Formule :C21H19NO6Degré de pureté :98%Couleur et forme :Off-White SolidMasse moléculaire :381.38EGFR ligand-11
CAS :EGF Rligand-11, a target protein ligand for EGFR, is utilized in the synthesis of PROTAC MS154.Formule :C25H29ClFN5O4Couleur et forme :SolidMasse moléculaire :517.98RG14620
CAS :RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.Formule :C14H8Cl2N2Degré de pureté :99.56% - 99.82%Couleur et forme :SolidMasse moléculaire :275.13Ref: TM-T3554
2mg35,00€5mg52,00€10mg77,00€25mg137,00€50mg259,00€100mg432,00€500mg938,00€1mL*10mM (DMSO)58,00€BLU-945
CAS :BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).Cost-effective and quality-assured.Formule :C28H37FN6O3SDegré de pureté :99.11% - 99.16%Couleur et forme :SolidMasse moléculaire :556.71,5-Dihydroxyxanthone
CAS :1,5-Dihydroxyxanthone inhibits EGFR-tyrosine kinase (IC50: 90.34 nM) and may block AChE/BChE.Formule :C13H8O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :228.203DA-0157
CAS :DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.Formule :C31H43BrN7O2PCouleur et forme :SolidMasse moléculaire :656.597TYRPHOSTIN B48
CAS :Formule :C16H12N2O3Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :280.2781EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Couleur et forme :Odour SolidEGFR/HER2/DHFR-IN-3
EGFR/HER2/DHFR-IN-3 (compound 4c) serves as an efficacious dual inhibitor specifically targeting EGFR/HER2, exhibiting IC50 values of 0.138 μM for EGFR and 0.Degré de pureté :98%Couleur et forme :Odour SolidIBI-334
IBI-334 is a bispecific antibody targeting both B7-H3 and EGFR. It features an EGFR arm responsible for signal blocking, connected to a modified B7-H3 arm that ensures optimal affinity and binding. The antibody is afucosylated to enhance its antibody-dependent cellular cytotoxicity (ADCC) effects. IBI-334 is widely applicable in EGFR-driven solid tumors.Couleur et forme :Odour LiquidBI-4020
CAS :BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase.Formule :C30H38N8O2Degré de pureté :100.00% - 98.44%Couleur et forme :SolidMasse moléculaire :542.68Ref: TM-T10534
1mg170,00€5mg398,00€10mg568,00€25mg848,00€50mg1.130,00€100mg1.510,00€200mg2.062,00€1mL*10mM (DMSO)472,00€CGP77675
CAS :CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates andFormule :C26H29N5O2Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :443.54Dalmitamig
Dalmitamig is a humanized IgG4κ antibody targeting EGFR/CD28, with HumanIgG4(S228P) kappa as its corresponding isotype control.Couleur et forme :Odour LiquidPD-149163 hydrochloride
PD-149163 hydrochloride is a neurokinin B agonist with antipsychotic activity, used for research on neurological diseases.Formule :C42H72ClN9O6Couleur et forme :SolidMasse moléculaire :834.53Rilematovir
CAS :Rilematovir (JNJ-678) inhibits fusion protein, has antiviral properties, low toxicity, and targets RSV treatment.Formule :C21H20ClF3N4O3SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :500.92Mutated EGFR-IN-1
CAS :Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activatingFormule :C25H31N7ODegré de pureté :98.91%Couleur et forme :SolidMasse moléculaire :445.56Allitinib tosylate
CAS :Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.Formule :C31H26ClFN4O5SDegré de pureté :98.46% - 98.68%Couleur et forme :SolidMasse moléculaire :621.08
