Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase
- CDK
- Arrêt du cycle cellulaire
- Chk
- c-Myc
- Dynamine
- DYRK
- Ferroptose
- HSP
- Intégrine
- Kinésine
- KSP
- LIM Kinase
- Microtubules associés
- PKC
- PLK
- Rho
- ROCK
- Wee1
Affichez 11 plus de sous-catégories
Produits appartenant à la catégorie "Cycle cellulaire/point de contrôle"
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CDK1-IN-6
CDK1-IN-6 (Ligand 3) is an effective inhibitor of CDK1 and shows potential for use in cancer research.Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.43Gallium maltolate
CAS :Gallium maltolate is a ribonucleoside-diphosphate reductase inhibitor.Formule :C18H15GaO9Degré de pureté :99.67% - 99.75%Couleur et forme :SolidMasse moléculaire :445.03Pyridostatin TFA
CAS :Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-Formule :C37H35F9N8O11Degré de pureté :97.09% - 99.84%Couleur et forme :SolidMasse moléculaire :938.71TMX-2039
CAS :TMX-2039 is a pan-CDK inhibitor that targets cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcription CDKs (CDK7 and CDK9), with IC50 values of 2.6, 1.0, 52.1, 0.5, 35.0, 32.5, and 25 nM, respectively. It serves as a ligand for the target protein in PROTAC applications.Formule :C17H20BrFN6O3SCouleur et forme :SolidMasse moléculaire :487.347Stigmatellin
CAS :Stigmatellin is an antibiotic derived from the cell mass of the myxobacterium, effective against yeasts (yeasts), filamentous fungi (filamentous fungi), and several Gram-positive bacteria (Gram-positive bacteria). Additionally, it serves as a potent inhibitor of photosynthetic electron (photosynthetic electron) transfer. Stigmatellin utilizes various sugars, polysaccharides, and acids from the citric acid cycle as substrates, inhibiting RNA and protein synthesis. It has two different inhibitory sites: one located on the reducing side of photosystem II and the other at the cytochrome b6/f complex. Stigmatellin holds potential for use in antimicrobial and photosynthesis research.Formule :C30H42O7Couleur et forme :SolidMasse moléculaire :514.65MGB-BP-3
CAS :MGB-BP-3 is a synthetic antibiotic with bactericidal activity that inhibits bacterial DNA replication and can be used to study recurrent C. difficile infections.Formule :C36H37N7O4Degré de pureté :97.06% - 98.92%Couleur et forme :SolidMasse moléculaire :631.72STX-100
PY314 is a CHO-expressed humanized monoclonal antibody targeting TREM2 with antitumor activity for the study of metastatic renal cell carcinoma.Degré de pureté :95% - 95%Couleur et forme :Odour Liquid2',3'-Dideoxyuridine
CAS :2',3'-Dideoxyuridine is a purine nucleoside analog with potential antitumor activity.Formule :C9H12N2O4Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :212.2WRN inhibitor 11
CAS :WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.Formule :C34H35ClF3N9O5Couleur et forme :SolidMasse moléculaire :742.15C16Y
CAS :C16Y, a short peptide, serves as an inhibitor for the integrins αvβ3 and α5β1. It targets the cell membrane and exerts its antitumor activity by inhibiting angiogenesis.Formule :C78H115N17O17Couleur et forme :SolidMasse moléculaire :1562.85EMD534085
CAS :EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).Formule :C25H31F3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.535-Methylcytosine
CAS :5-Methylcytosine is a methylated nucleotide base found in eukaryotic DNA.Formule :C5H7N3ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :125.13SRI-29329
CAS :SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Formule :C20H26ClN7Degré de pureté :99.18%Couleur et forme :SolidMasse moléculaire :399.92Ref: TM-T8801
1mg92,00€5mg188,00€10mg306,00€25mg520,00€50mg748,00€100mg1.026,00€1mL*10mM (DMSO)215,00€3-AP
CAS :3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).Formule :C7H9N5SDegré de pureté :97.33% - 99.75%Couleur et forme :SolidMasse moléculaire :195.24Ref: TM-T1982
2mg39,00€5mg57,00€10mg69,00€25mg150,00€50mg264,00€100mg400,00€500mg909,00€1mL*10mM (DMSO)57,00€Human PD-L1 inhibitor V
CAS :Human PD-L1 Inhibitor V is a peptide that binds to the human PD-1 protein with an affinity characterized by a dissociation constant (Kd) of 3.32 μM, effectivelyFormule :C65H104N20O18SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1485.71T521
CAS :T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.Formule :C17H14FNO5S2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :395.43AZ5576
CAS :AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].Formule :C21H24FN3O3Degré de pureté :99.88%Couleur et forme :SoildMasse moléculaire :385.43Ref: TM-T60152
1mg35,00€5mg80,00€10mg113,00€25mg221,00€50mg331,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)87,00€PROTAC CDK9 degrader-11
CAS :PROTAC CDK9 degrader-11 (Compound C3) is an orally active PROTAC CDK9 degrader with a DC50 of 1.09 nM. This compound exhibits cytotoxicity in small cell lung cancer (SCLC) cells, with IC50 values in the nanomolar range. It induces cell cycle arrest at the G0/G1 phase and inhibits cell invasion in DMS114 and DMS53 cells. In addition, PROTAC CDK9 degrader-11 shows antitumor activity in an NCI-H446 xenograft mouse model. (Pink: ligand for target protein CDK9 ligand 3; Black: linker; Blue: ligand for E3 ligase Cereblon E3 ligase Ligand 56)Formule :C39H48Cl2N10O5Couleur et forme :SolidMasse moléculaire :807.768SCH900776 (S-isomer)
CAS :SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM).Formule :C15H18BrN7Degré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :376.25Ref: TM-T3700
1mg49,00€2mg70,00€5mg96,00€10mg155,00€25mg264,00€50mg424,00€100mg627,00€1mL*10mM (DMSO)114,00€Senexin C
CAS :Senexin C is a CDK8/19 inhibitor with anticancer activity.Senexin C inhibits the growth of MV4-11 leukemia cells.Formule :C28H27N5ODegré de pureté :97.91%Couleur et forme :SolidMasse moléculaire :449.55DAM-IN-1
CAS :DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor with an IC50 value of 48 μM.Formule :C16H17NO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :287.31Aminopurvalanol A
CAS :Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1Formule :C19H26ClN7ODegré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :403.91Ref: TM-T22260
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg284,00€100mg411,00€200mg585,00€1mL*10mM (DMSO)65,00€Sintilimab
CAS :Sintilimab (IBI308), an IgG4 monoclonal antibody, blocks PD-1, enhancing T-cell anti-tumor response; treats Hodgkin's, lung, and esophageal cancers.Degré de pureté :> 95%Couleur et forme :LiquidMasse moléculaire :144.04 kDaAtuveciclib S-Enantiomer
CAS :Atuveciclib S-Enantiomer is a (S)-form of BAY-1143572; a potent, selective CDK9 inhibitor with an IC50 of 16 nM.Formule :C18H18FN5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :387.43PD-1-IN-22
CAS :PD-1-IN-22 is a potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor(IC50 of 92.3 nM).Formule :C25H25N5O4Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :459.5Ref: TM-T12379
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)299,00€CFI-402257
CAS :CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.Formule :C28H30N6O3Degré de pureté :96.66% - 99.51%Couleur et forme :SolidMasse moléculaire :498.58CDK9-Cyclin T1 PPI-IN-1
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBCDegré de pureté :98%Couleur et forme :Odour SolidDamnacanthal
CAS :Damnacanthal is a natural anthraquinone with potential anticancer property, inhibiting a variety of protein kinases such as LIMK1, LIMK2 and Lck.Formule :C16H10O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :282.25RNA polymerase II-IN-1
CAS :RNA polymerase II-IN-1 (19iv), an amatoxin, inhibits Pol II at 36.66 nM IC50, is more toxic to cancer cells, less to normal cells than α-Amanitin.Formule :C38H53N11O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :887.96SAR-020106
CAS :SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.Formule :C19H19ClN6ODegré de pureté :97.78%Couleur et forme :SolidMasse moléculaire :382.85CDK4-IN-1
CAS :CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50Formule :C22H29ClN8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :440.97Aurora A inhibitor 3
Aurora A Inhibitor 3 (Compound 5h) effectively inhibits Aurora-A kinase, exhibiting an IC50 of 0.78 μM, and demonstrates cytotoxicity against MCF-7 and MDA-MB-Degré de pureté :98%Couleur et forme :Odour SolidProguanil
CAS :Proguanil (Chloroguanide) is a prophylactic antimalarial drug that acts primarily through its active metabolite, Cycloguanil, which inhibits the DHFR enzyme .Formule :C11H16ClN5Degré de pureté :99.6%Couleur et forme :SolidMasse moléculaire :253.73KW-2449
CAS :KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Formule :C20H20N4ODegré de pureté :98.43% - 99.89%Couleur et forme :SolidMasse moléculaire :332.45-Aza-7-deazaguanine
CAS :5-Aza-7-deazaguanine is a non-natural substituted nucleobase with potential antiviral activity, used in cancer and bacterial infection research.Formule :C5H5N5ODegré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :151.138-Azaguanosine
CAS :8-Azaguanosine is a purine nucleoside analog with a broad spectrum of antitumor activity and is used in the study of a variety of tumor diseases.Formule :C9H12N6O5Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :284.23BI8622
CAS :BI8622 is a HUWE1 antagonist that restores levels of RP2 mutants in retinal cell lines and inhibits cellular activation of NLRP3 and AIM2 inflammatory vesicles.Formule :C25H26N6ODegré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :426.51(S)-Enitociclib
CAS :(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that inhibits the transcription of anti-apoptotic and pro-survival proteins.Formule :C19H18F2N4O2SDegré de pureté :98.04%Couleur et forme :SolidMasse moléculaire :404.43Nicotinamide N-oxide
CAS :Nicotinamide N-oxide, a metabolite of nicotinamide and precursor to NAD+, is reduced by liver enzyme xanthine oxidase.Formule :C6H6N2O2Degré de pureté :99.61% - 99.9%Couleur et forme :SolidMasse moléculaire :138.12AS2863619
CAS :AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formule :C16H14Cl2N8ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :405.24Ref: TM-T8378
1mg131,00€2mg180,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)303,00€CDK8/19-IN-51
CAS :CDK8/19-IN-51 is a CDK8 and CDK19 inhibitor with anticancer activity, used in research on colorectal and gastric cancers.Formule :C23H22N6O2Degré de pureté :100% - 98.65%Couleur et forme :SoildMasse moléculaire :414.46KOdiA-PC
CAS :KOdiA-PC is a truncated oxidized phospholipid and a CD36-targeting ligand found on oxLDL. It inhibits activation of TLR4 signaling components.Formule :C32H58NO11PCouleur et forme :SolidMasse moléculaire :663.78Envafolimab
CAS :Envafolimab (ASC 22) is a humanized antibody targeting PD-L1, with anticancer activity, blocking the PD-L1 and PD-1 interaction.Degré de pureté :95%Couleur et forme :LiquidLY2880070
CAS :LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy.Formule :C19H23N7O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :381.43Ref: TM-T9252
1mg131,00€5mg286,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)316,00€WAY-647802
CAS :WAY-647802 is a CDK inhibitor.Formule :C11H14N4O3Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :250.25Madrasin
CAS :Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly.Formule :C16H17N5O2Degré de pureté :99.44% - 99.61%Couleur et forme :SolidMasse moléculaire :311.34PD-1/PD-L1-IN-51
PD-1/PD-L1-IN-51 (Compound III-4) is an inhibitor of PD-1/PD-L1 (IC50: hPD-L1 at 2.9 nM). It binds directly to PD-L1, blocking the interaction between PD-1 and PD-L1, and enhancing the release of IFN-γ. Additionally, PD-1/PD-L1-IN-51 exhibits antitumor activity.Couleur et forme :Odour SolidCCT 137690
CAS :CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).Formule :C26H31BrN8ODegré de pureté :98.51% - 99.82%Couleur et forme :SolidMasse moléculaire :551.485'-O-DMT-N4-Bz-5-Me-dC
CAS :5'-O-DMT-N4-Bz-5-Me-dC (DMT-NBZ-5-METHYL DC) is a modified nucleoside used in the synthesis of nucleoside phosphoramidites.Formule :C38H37N3O7Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :647.72Efalizumab
CAS :Efalizumab: humanized monoclonal antibody CD11a; modulates T cell activation/adhesion; for plaque psoriasis, psoriatic arthritis research.Degré de pureté :SDS-PAGE:95% SEC-HPLC:98.77%Couleur et forme :LiquidMasse moléculaire :146.14 kDaSR 11302
CAS :SR 11302 is an inhibitor of activator protein-1 (AP-1).Formule :C26H32O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :376.53Ref: TM-T23384
1mg137,00€5mg492,00€10mg797,00€25mg1.385,00€50mgÀ demander100mgÀ demander1mL*10mM (DMSO)550,00€Nedaplatin
CAS :Nedaplatin, a cisplatin derivative, induces tumor DNA damage (IC50: 94 μM) through platinum-DNA cross-links, causing apoptosis.Formule :C2H8N2O3PtDegré de pureté :100% - 98.69%Couleur et forme :Straw Yellow PowderMasse moléculaire :303.17A-205804
CAS :A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.Formule :C15H12N2OS2Degré de pureté :98.07% - 98.52%Couleur et forme :SolidMasse moléculaire :300.4Ref: TM-T2254
2mg44,00€5mg52,00€10mg81,00€25mg160,00€50mg271,00€100mg532,00€500mg1.169,00€1mL*10mM (DMSO)71,00€N-6-Furfurylguanosine
CAS :N-6-Furfurylguanosine (kinetin riboside) is a purine nucleoside analog with cytotoxicity, inhibiting the growth of cancer cells.Formule :C15H18N6O5Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :362.34Ancitabine hydrochloride
CAS :Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity.Formule :C9H12ClN3O4Degré de pureté :99.02% - 99.37%Couleur et forme :White SolidMasse moléculaire :261.66Uridine-5-acetic acid
CAS :Uridine-5-acetic acid (5-Carboxymethyluridine) is a nucleoside formed during RNA transfer processes in yeast and wheat embryos.Formule :C11H14N2O8Degré de pureté :99.59%Couleur et forme :SolidMasse moléculaire :302.24PolQi2
CAS :PolQi2 is a Polθ inhibitor that suppresses the helicase activity of Polθ, and when combined with AZD7648.Formule :C21H16ClN5O3SDegré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :453.9Ref: TM-T84770
1mg92,00€5mg188,00€10mg313,00€25mg603,00€50mg840,00€100mg1.169,00€200mg1.586,00€1mL*10mM (DMSO)216,00€CHK1 inhibitor
CAS :CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.Formule :C17H21BrN4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :377.28Saccharin 1-methylimidazole
CAS :Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.Formule :C7H5NO3S·C4H6N2Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :265.29THZ1
CAS :THZ1 (CDK7 inhibitor) is a selective inhibitor of CDK7, binding to the Cys residue located at the outer end of the classical kinase domain. Cost-effective and quality-assured.Formule :C31H28ClN7O2Degré de pureté :95.09% - 99.27%Couleur et forme :SolidMasse moléculaire :566.05Antiviral agent 36
Antiviral agent 36 (compound 27), a potent inhibitor of both dengue (DENV) and Zika (ZIKV) viruses, demonstrates replication inhibition with EC50 values of 100Formule :C30H32N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :496.6m-Se3
CAS :m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].Formule :C29H23IN2SeDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :605.37CDK2-IN-4
CAS :CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A.Formule :C23H18N6O2SDegré de pureté :97.24% - 99.10%Couleur et forme :SolidMasse moléculaire :442.49Ref: TM-T14916
1mg87,00€5mg202,00€10mg321,00€25mg550,00€50mg753,00€100mg1.074,00€1mL*10mM (DMSO)240,00€Bersiporocin
CAS :Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.Formule :C15H19Cl2N3ODegré de pureté :100% - 98.88%Couleur et forme :SolidMasse moléculaire :328.24ON-013100
CAS :ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Formule :C19H22O7SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :394.44Ref: TM-T16391
1mg50,00€5mg74,00€10mg105,00€25mg182,00€50mg283,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)64,00€ICAM-1-IN-1
CAS :ICAM-1-IN-1 is a potent and selective E-selectin(IC50 = 7 nM) and ICAM-1(IC50 = 5 nM) inhibitor.Formule :C15H11BrN2O2SDegré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :363.23Ref: TM-T13147
1mg185,00€5mg393,00€10mg587,00€25mg935,00€50mg1.264,00€100mg1.700,00€500mg3.410,00€1mL*10mM (DMSO)432,00€CDK2-IN-40
CAS :CDK9-IN-40 is an inhibitor of CDK2 (Cyclin-dependent kinase 2). It effectively inhibits CDK2/Cyclin E1, with an IC50 of ≤ 10 nM.Formule :C16H21N7O2Couleur et forme :SolidMasse moléculaire :343.384MYCi361
CAS :MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).Formule :C26H16ClF9N2O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :594.86Dimethylenastron
CAS :Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.Formule :C16H18N2O2SDegré de pureté :98.07%Couleur et forme :SolidMasse moléculaire :302.39Ref: TM-T3118
1mg35,00€2mg48,00€5mg62,00€10mg87,00€25mg156,00€50mg235,00€100mg354,00€1mL*10mM (DMSO)67,00€Ribociclib succinate
CAS :Ribociclib succinate (LEE011 succinate) is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively).Formule :C27H36N8O5Degré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :552.63Ref: TM-T15732
2mg35,00€5mg51,00€10mg73,00€25mg97,00€50mg115,00€100mg168,00€200mg271,00€500mg484,00€1mL*10mM (DMSO)64,00€HAMNO
CAS :HAMNO (NSC-111847) is a protein interaction inhibitor of replication protein A (RPA).Formule :C17H13NO2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :263.29BML-259
CAS :BML-259 inhibits CDK5/CDK2 (IC50: 64/98 nM) for cancer and neurodegeneration research.Formule :C14H16N2OSDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :260.35Ref: TM-T36964
5mg50,00€10mg85,00€25mg169,00€50mg279,00€100mg487,00€500mg1.035,00€1mL*10mM (DMSO)52,00€WRN inhibitor 14
WRN inhibitor 14 (compound S35) is an orally administered WRN inhibitor with anticancer properties. It effectively suppresses tumor growth in the SW48 xenograft model in BALB/c nude mice.Formule :C35H40F4N10O5Couleur et forme :SolidMasse moléculaire :756.75Bimosiamose disodium
CAS :Bimosiamose disodium (TBC-1269Z), a pan-selectin inhibitor, has IC50s: E-selectin 88 μM, P-selectin 20 μM, L-selectin 86 μM; anti-inflammatory.Formule :C46H52Na2O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :906.888-Bromoadenosine
CAS :8-Bromoadenosine is an adenosine derivative. 8-Br-Adenosine inhibitis mitochondrial membrane potential, cytoplasmic Ca²⁺ levels, and RNA and protein synthesis.Formule :C10H12BrN5O4Degré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :346.14SEL120-34A
CAS :SEL120-34A inhibits CDK8 (IC50: 4.4 nM) & CDK19 (10.4 nM), less on CDK9 (1070 nM), has antitumor properties.Formule :C15H18Br2N4Degré de pureté :100% - 99.7%Couleur et forme :SolidMasse moléculaire :414.14NSAH
CAS :NSAH (2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide) is a nonnucleoside inhibitor of human ribonucleotide reductase (hRR).with cell-Formule :C18H14N2O3Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :306.32Ref: TM-T8800
5mg70,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)77,00€CDK8-IN-1
CAS :CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).Formule :C11H8F3N3ODegré de pureté :97.09%Couleur et forme :SolidMasse moléculaire :255.2Ref: TM-T10740
1mg87,00€5mg216,00€10mg311,00€25mg525,00€50mg707,00€100mg944,00€1mL*10mM (DMSO)240,00€Rifalazil
CAS :Rifalazil (KRM-1648) is a benzophenazine antibiotic with antibacterial activity, useful for research on chlamydia infections.Formule :C51H64N4O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :941.07GTSE1-IN-1
CAS :GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.Formule :C21H24FN7Couleur et forme :SolidMasse moléculaire :393.46Rifapentine
CAS :Rifapentine (Rifapentinum) is a long-acting, cyclopentyl-substituted derivative of rifamycin used to treat mycobacterium infections.Formule :C47H64N4O12Degré de pureté :95.74% - ≥98%Couleur et forme :SolidMasse moléculaire :877.032-Methylbiphenyl-oxadiazole-NH-Ph-CHO
CAS :2-Methylbiphenyl-oxadiazole-NH-Ph-CHO functions as a PD-L1 ligand for AUTACPD-L1degrader-3. It is also applicable in the synthesis of AUTAC.Formule :C22H17N3O2Couleur et forme :SolidMasse moléculaire :355.39Ganciclovir
CAS :Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus.Formule :C9H13N5O4Degré de pureté :99.4% - 99.55%Couleur et forme :White PowderMasse moléculaire :255.23Werner syndrome RecQ helicase-IN-2
CAS :Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.Formule :C32H34F3N9O5Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :681.67Digeranyl bisphosphonate
CAS :Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.DigeranylFormule :C21H34Na4O6P2Degré de pureté :98.5%Couleur et forme :SolidMasse moléculaire :536.4Cyclapolin 9
CAS :Cyclapolin 9: Selective PLK1 inhibitor, IC50 500 nM, ATP-competitive, inactive against other kinases.Formule :C9H4F3N3O4SDegré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :307.21Ref: TM-T22700
1mg92,00€5mg216,00€10mg338,00€25mg540,00€50mg747,00€100mg1.017,00€500mg2.043,00€1mL*10mM (DMSO)240,00€Seliciclib
CAS :Seliciclib (Roscovitine) is a potent inhibitor of Cdk2/cyclin E, also inhibits Cdk7, Cdk5 and Cdc2. Seliciclib has antitumor effect. Cost-effective, quality assurance.Formule :C19H26N6ODegré de pureté :97.15% - 99.88%Couleur et forme :White To Off-White SolidMasse moléculaire :354.45NVP-LCQ195
CAS :NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Formule :C17H19Cl2N5O4SDegré de pureté :100% - 99.36%Couleur et forme :SolidMasse moléculaire :460.33Ref: TM-TQ0068
1mg48,00€5mg97,00€10mg145,00€25mg269,00€50mg395,00€100mg563,00€200mg743,00€1mL*10mM (DMSO)99,00€Deoxyguanosine triphosphate trisodium salt
CAS :Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) is a nucleotide precursor for DNA synthesis in cells and can beFormule :C10H13N5Na3O13P3Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :573.13WRN inhibitor 18
CAS :WRN inhibitor 18 (compound 306) is an orally active inhibitor of WRN with demonstrated anticancer activity in vivo.Formule :C35H35F6N5O5SCouleur et forme :SolidMasse moléculaire :751.747-Methylxanthine
CAS :7-Methylxanthine, a xanthine methyl derivative, prevents FDM by altering the sclera in rabbits. It's a purine in kidney stones.Formule :C6H6N4O2Degré de pureté :97.66% - 98.58%Couleur et forme :SolidMasse moléculaire :166.14sAJM589
CAS :sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels and inhibiting the cellular proliferation.Formule :C16H10N2ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :246.266-Mercaptopurine hydrate
CAS :6-Mercaptopurine hydrate is a leukemia treatment; it blocks purine metabolism, affecting DNA synthesis.Formule :C5H6N4OSDegré de pureté :97.54% - 99.14%Couleur et forme :Light Yellow Crystalline PowderMasse moléculaire :170.19Nusinersen
CAS :Nusinersen (nusinersen) is a antisense oligonucleotide (ASO) for the treatment of pediatric and adult spinal muscular atrophy (SMA) and increases SMN proteinss.Couleur et forme :SolidMirvetuximab soravtansine
CAS :Mirvetuximab soravtansine (IMGN853) is an antibody-drug coupling that targets FRα, inhibits cell growth, and can be used to study drug-resistant ovarian cancerDegré de pureté :95%Couleur et forme :LiquidButyrolactone I
CAS :Butyrolactone I (Olomoucin) inhibits CDKs, blocks cdc2 kinases, and shows antitumor activity in lung and prostate cancers.Formule :C24H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :424.44CDK4/6-IN-17
CAS :CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells.Formule :C27H28F4N8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :540.56CDK9-IN-24
CDK9-IN-24 (compound 21a) is a potent and selective inhibitor of CDK9 that exhibits a pronounced inhibitory impact on tumor proliferation.Formule :C27H31N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :461.55PD-1/PD-L1-IN-34
CAS :PD-1/PD-L1-IN-34 (Compound (1S,2S)-A25) effectively inhibits the PD-1/PD-L1 interaction (IC 50 = 0.029 μM) and demonstrates selective binding affinity to PD-L1Formule :C35H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.1CDK9-IN-28
PROTAC CDK9/CycT1 Degrader-1 (compounds 10), a potent CDK9 inhibitor, serves as a target protein ligand for PROTAC synthesis.Formule :C32H40N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :640.81
