
Cycle cellulaire/point de contrôle
Les inhibiteurs du cycle cellulaire/des points de contrôle sont des composés qui perturbent la progression normale du cycle cellulaire, en particulier aux points de contrôle régulateurs clés. Ces inhibiteurs sont cruciaux pour étudier la division cellulaire, comprendre la prolifération des cellules cancéreuses et développer des thérapies anticancéreuses. En ciblant des phases spécifiques du cycle cellulaire, ces inhibiteurs peuvent induire un arrêt du cycle cellulaire, conduisant à l'apoptose ou à la sénescence des cellules à division rapide. Chez CymitQuimica, nous offrons une large gamme d'inhibiteurs de haute qualité du cycle cellulaire/des points de contrôle pour soutenir vos recherches en biologie du cancer, biologie cellulaire et développement de médicaments.
Sous-catégories appartenant à la catégorie "Cycle cellulaire/point de contrôle"
- Aurora Kinase
- CDK
- Arrêt du cycle cellulaire
- Chk
- c-Myc
- Dynamine
- DYRK
- Ferroptose
- HSP
- Intégrine
- Kinésine
- KSP
- LIM Kinase
- Microtubules associés
- PKC
- PLK
- Rho
- ROCK
- Wee1
Affichez 11 plus de sous-catégories
Produits appartenant à la catégorie "Cycle cellulaire/point de contrôle"
Trier par
2'-O-(2-Azidoethyl)adenosine
CAS :2'-O-(2-azidoethyl)adenosine is a purine nucleoside analog with potential antitumor activity.Formule :C12H16N8O4Degré de pureté :95%Couleur et forme :SolidMasse moléculaire :336.31N-desmethyl Netupitant
CAS :N-desmethyl Netupitant is a metabolite of Netupitant and a potential Substance-P receptor agonist.Formule :C29H30F6N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :564.57PKMYT1-IN-4
PKMYT1-IN-4 (compound 27) functions as a PKMYT1 inhibitor with an IC50 value under 50 nM.Formule :C19H15F3N4O2Couleur et forme :SolidMasse moléculaire :388.34NSC23005
CAS :NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Formule :C13H17NO4SDegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :283.34WEE1-IN-3
CAS :WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.Formule :C28H31N7O2Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :497.59Ref: TM-T8916
1mg70,00€5mg156,00€10mg239,00€25mg419,00€50mg562,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€A-286982
CAS :A 286982 blocks the LFA-1 and ICAM-1 integrin-ligand interaction.Formule :C24H27N3O4SDegré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :453.55Ref: TM-T21781
1mg35,00€2mg50,00€5mg74,00€10mg107,00€25mg210,00€50mg350,00€100mg522,00€1mL*10mM (DMSO)81,00€CDK2-IN-19
CDK2-IN-19 (Compound 32) is a selective, orally active inhibitor of CDK2 (K i: 0.18 nM) that exhibits anticancer activity in mice with OVCAR3 tumors [1].Formule :C20H21FN6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :460.48CC-671
CAS :CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.Formule :C28H28N6O4Degré de pureté :98.35% - 98.65%Couleur et forme :SolidMasse moléculaire :512.56Ref: TM-T4482
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg540,00€100mg775,00€500mg1.596,00€1mL*10mM (DMSO)127,00€Rhosin
CAS :Rhosin is a specific inhibitor of RhoA GTPases (Kd: ~0.4 uM), blocking RhoA-GEF interaction, not affecting Cdc42/Rac1/LARG, and induces apoptosis.Formule :C20H18N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :358.43MB-PP1
CAS :3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor.Formule :C17H21N5Degré de pureté :99.97%Couleur et forme :White SolidMasse moléculaire :295.38Ref: TM-T21678
5mg52,00€10mg96,00€25mg170,00€50mg269,00€100mg394,00€500mgÀ demander1mL*10mM (DMSO)58,00€2-Chloropyrazine
CAS :2-Chloropyrazine is used in chemical industry.Formule :C4H3ClN2Degré de pureté :98.98% - 99.81%Couleur et forme :Clear Colorless To Yellowish LiquidMasse moléculaire :114.53Trilaciclib
CAS :Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).Formule :C24H30N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :446.55NG 52
CAS :NG 52 (NG-52) is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase.Formule :C16H19ClN6ODegré de pureté :98% - 99.36%Couleur et forme :SolidMasse moléculaire :346.81Ref: TM-T2028
1mg74,00€2mg97,00€5mg158,00€10mg269,00€25mg515,00€50mg743,00€100mg1.035,00€500mg2.080,00€1mL*10mM (DMSO)158,00€5-Bromouridine
CAS :5-Bromouridine is a antitumor uracil derivative that induces apoptosis in cancer cells by inhibiting DNA synthesis and is also a marker for DNA and RNA.Formule :C9H11BrN2O6Degré de pureté :99.89%Couleur et forme :White PowderMasse moléculaire :323.1CDK9-IN-15
CAS :CDK9-IN-15: potent CDK9 inhibitor, blocks P-TEFb phosphorylation, inhibits transcription, reduces mRNA, induces tumor cell apoptosis.Formule :C16H11N3OSDegré de pureté :97.24%Couleur et forme :SolidMasse moléculaire :293.34Ref: TM-T60619
2mg42,00€5mg64,00€10mg97,00€25mg183,00€50mg273,00€100mg393,00€200mg550,00€1mL*10mM (DMSO)62,00€Fosifloxuridine nafalbenamide
CAS :Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.Formule :C29H29FN3O9PDegré de pureté :95.87%Couleur et forme :SolidMasse moléculaire :613.53Ref: TM-T33762
1mg88,00€5mg160,00€10mg216,00€25mg393,00€50mg550,00€100mg753,00€500mg1.549,00€1mL*10mM (DMSO)210,00€Retifanlimab
CAS :Retifanlimab (MGA-012) is a monoclonal antibody targeting programmed cell death protein 1 (PD-1). Retifanlimab is used in studies of Merkel cell carcinoma.Degré de pureté :95% - 95%Couleur et forme :Liquid2'-O-Methyl-2-thiouridine
CAS :2'-O-Methyl-2-thiouridine, a purine nucleoside analog present in synthetic thermophilic bacterial tRNAs, is more selective for A than unmodified U.Formule :C10H14N2O5SDegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :274.292'-O-Methylinosine
CAS :2'-O-Methylinosine (2'-(o-Methyl)-inosine) is an orally bioavailable purine nucleoside analog with antihypertensive activity.Formule :C11H14N4O5Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :282.25B I09
CAS :B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells.Formule :C16H17NO5Degré de pureté :99.23%Couleur et forme :SolidMasse moléculaire :303.31Activated Protein C (390-404), human acetate
Activated Protein C (390-404), human acetate (Activated Protein C ) inhibits APC anticoagulant activity.Formule :C93H134N22O25Degré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :1960.19ML-60218
CAS :ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.Formule :C19H15Cl2N3O2S2Degré de pureté :98.1%Couleur et forme :SolidMasse moléculaire :452.38Ref: TM-T40661
1mg56,00€5mg119,00€10mg187,00€25mg411,00€50mg638,00€100mg908,00€200mg1.225,00€1mL*10mM (DMSO)131,00€Filanesib
CAS :Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.Formule :C20H22F2N4O2SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :420.48Rabusertib
CAS :Rabusertib (IC-83) is a chk1 inhibitor in trials for various cancers, including pancreatic and non-small cell lung cancer.Formule :C18H22BrN5O3Degré de pureté :98.86% - 99.63%Couleur et forme :SolidMasse moléculaire :436.3BMS-1166
CAS :BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.Formule :C36H33ClN2O7Degré de pureté :99.22%Couleur et forme :SolidMasse moléculaire :641.11Ref: TM-T5697
1mg74,00€5mg155,00€10mg225,00€25mg429,00€50mg635,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)208,00€6-AZATHYMINE
CAS :6-azathymine inhibits D-3-aminoisobutyrate-pyruvate aminotransferase; 6-azauracil competes with beta-alanine, uncompetitive with pyruvic acid, Ki ~8.9 mM.Formule :C4H5N3O2Degré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :127.1CHK1-IN-3
CAS :CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM).Formule :C20H23N9ODegré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :405.46Ref: TM-T10791
1mg185,00€2mg279,00€5mg424,00€10mg627,00€25mg938,00€50mg1.311,00€100mg1.795,00€1mL*10mM (DMSO)470,00€Y16 acetate(429653-73-6 free base)
Y16 acetate(429653-73-6 free base) is a G-protein-coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoAFormule :C51H74N14O13Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1091.24Sangivamycin
CAS :Sangivamycin (NSC-65346) inhibits PKC (Ki=10μM) and hinders growth in various human cancers.Formule :C12H15N5O5Degré de pureté :98.11%Couleur et forme :SolidMasse moléculaire :309.28Ref: TM-T9605
1mg126,00€5mg274,00€10mg416,00€25mg677,00€50mg944,00€100mg1.264,00€1mL*10mM (DMSO)360,00€Thiarabine
CAS :Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.Formule :C9H13N3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :259.28CP-07
CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formationFormule :C45H48N6O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :800.95,6-Dihydro-5-methyluracil
CAS :5,6-Dihydro-5-methyluracil (Dihydrothymine) is an intermediate breakdown product of thymine.Formule :C5H8N2O2Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :128.13Dostarlimab
CAS :Dostarlimab (TSR-042) is an immune checkpoint inhibitor targeting PD-1, blocking its interaction with its ligands PD-L1 and PD-L2.Degré de pureté :>95%Couleur et forme :LiquidGW406108X(Z/E)
CAS :GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .Formule :C20H11Cl2NO4Degré de pureté :98.23%Couleur et forme :SolidMasse moléculaire :400.21Ref: TM-T9207L
1mg131,00€5mg286,00€10mg430,00€25mg647,00€50mg969,00€100mg1.301,00€1mL*10mM (DMSO)283,00€MBQ-167
CAS :MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formule :C22H18N4Degré de pureté :98.07% - 98.74%Couleur et forme :SolidMasse moléculaire :338.41Ref: TM-T16021
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg208,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)87,00€RP-6685
CAS :RP-6685 is a potent, selective DNA Polθ inhibitor with strong oral efficacy, an IC50 of 5.8 nM, and marked antitumor effects in mice.Formule :C22H14F7N5ODegré de pureté :98.34%Couleur et forme :SoildMasse moléculaire :497.37Ref: TM-T60187
1mg88,00€5mg160,00€10mg230,00€25mg378,00€50mg538,00€100mg755,00€1mL*10mM (DMSO)170,00€dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formule :C52H53Cl2FN8O12Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :1071.93CDK9-IN-35
CDK9-IN-35 (compound 10j) acts as an inhibitor of CDK9/CyclinT1, exhibiting an IC50 of 10.2 nM. It also shows an IC50 of 20 nM against the HCT-116 cell line.Formule :C26H24ClFN4O4SCouleur et forme :SolidMasse moléculaire :543.01Anticancer agent 73
CAS :Anticancer agent 73 inhibits TRBP, disrupting TRBP-Dicer, and hinders HCC growth and spread by altering HCC miRNA and protein expression.Formule :C14H15NO4Degré de pureté :99.19%Couleur et forme :SolidMasse moléculaire :261.27Rifaximin
CAS :Rifaximin: an oral semi-synthetic antibiotic from rifamycin SV; targets bacterial RNA polymerase to halt growth.Formule :C43H51N3O11Degré de pureté :98.05% - 99.40%Couleur et forme :Red-Orange Crystalline PowderMasse moléculaire :785.88Men 10376
CAS :Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.Formule :C57H68N12O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1081.22Nivolumab
CAS :Nivolumab is a monoclonal antibody, a humanized IgG4 antibody to PD-1. Nivolumab has antitumor activity. Cost-effective and quality-assured.Degré de pureté :98% - 98%Couleur et forme :LiquidMasse moléculaire :146 kDa2',3'-Bis-(O-t-butyldimethylsilyl)uridine
CAS :2',3'-Bis-(O-t-butyldimethylsilyl)uridine is a nucleoside derivative protect the NH2/OH groups of nucleosides.inhibitory on viral replication,AIDS and herpes.Formule :C21H40N2O6Si2Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :472.72Ref: TM-TNU1182
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Vitamin D2
CAS :Ergocaliferol (Vitamin D2), derived from ergosterol by UV, inhibits bladder tumor promotion and leukemia, and blocks DNA Polymerase.Formule :C28H44ODegré de pureté :98.73% - ≥98%Couleur et forme :Prisms From Acetone 1998)Masse moléculaire :396.65Aurora Kinases-IN-4
CAS :Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Formule :C26H28N8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.55P8RI acetate
P8RI acetate mimics CD31, activates CDP8RI, and suppresses the immune response by restoring CD31 pathway.Formule :C53H81N13O11Degré de pureté :99.61%Couleur et forme :SolidMasse moléculaire :1076.29Beaucage reagent
CAS :Beaucage reagent, which is found to be effective in causing DNA cleavage.Formule :C7H4O3S2Degré de pureté :95.19%Couleur et forme :White To Off-White PowderMasse moléculaire :200.23Abemaciclib metabolite M20
CAS :Abemaciclib metabolite M20 (CDK4/6-IN-4) 是 Abemaciclib 的活性代谢物。 Abemaciclib metabolite M20 是一种特异性 CDK4/6 抑制剂,可用于癌症治疗的相关研究。Formule :C27H32F2N8ODegré de pureté :98.32% - 99.29%Couleur et forme :SolidMasse moléculaire :522.59CDK2/Bcl2-IN-1
CDK2/Bcl2-IN-1 (compound 1) is a saponin-based inhibitor of CDK-2 (IC50=117.6 nM) that exhibits potent cytotoxic effects on cancer cells.Formule :C35H56O10SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :668.88RAD51-IN-1
CAS :Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.Formule :C22H16ClN3ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :373.833-Deazauridine
CAS :3-Deazauridine (NSC-126849), a uridine analog, blocks CTP synthesis by competing with CTP synthetase.Formule :C10H13NO6Degré de pureté :98.55%Couleur et forme :SolidMasse moléculaire :243.21Mevociclib
CAS :Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both hematological and solid tumors.Formule :C31H35ClN8O2Degré de pureté :98.02% - 98.02%Couleur et forme :SolidMasse moléculaire :587.112-Methylbutyrylcarnitine chloride
2-Methylbutyrylcarnitine (chloride) acts as a gut microbial metabolite that targets integrin α2β1 on platelets, facilitating the activation of cytosolic phospholipase A2 (cPLA2) and enhancing platelet hyperresponsiveness. This compound further augments platelet hyperreactivity and promotes thrombus formation in mice. It is also characterized as a branched-chain acylcarnitine.Formule :C12H24ClNO4Couleur et forme :SolidMasse moléculaire :281.78GS-443902
CAS :Remdesivir triphosphate (GS-443902) inhibits RSV/HCV RdRp with IC50s: 1.1/5 µM.Formule :C12H16N5O13P3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :531.2MU1409
CAS :MU1409 is an MRE11 nuclease inhibitor with an IC50 of 12.1 μM. It also inhibits FEN1 and EXO1, with IC50 values of 24.2 μM and 176.4 μM, respectively. MU1409 impacts cellular DNA repair and prevents the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for studying BRCA2 mutation-induced cancers.Formule :C20H14BrN3O3SCouleur et forme :SolidMasse moléculaire :456.312Senexin A
CAS :Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Formule :C17H14N4Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :274.32Ref: TM-T5673
1mg37,00€5mg77,00€10mg99,00€25mg187,00€50mg340,00€100mg485,00€200mg657,00€1mL*10mM (DMSO)74,00€Centrinone-B
CAS :Centrinone-B (LCR-323) is a Plk4 inhibitor with potential anticancer activity for the study of triple-negative breast cancer.Formule :C27H27F2N7O5S2Degré de pureté :98.71%Couleur et forme :SolidMasse moléculaire :631.67PD-1/PD-L1-IN-9
CAS :PD-1/PD-L1-IN-9, with an IC50 of 3.8 nM, is a potent and orally active inhibitor of the PD-1/PD-L1 interaction.Formule :C22H24N2O2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T9651
1mg60,00€2mg89,00€5mg134,00€10mg188,00€25mg314,00€50mg429,00€100mg565,00€500mg1.121,00€1mL*10mM (DMSO)148,00€T7 RNA polymerase
CAS :T7 RNA polymerase, expressed by Escherichia coli from the T7 bacteriophage RNA polymerase gene, is a highly specific enzyme utilized for in vitro transcriptionDegré de pureté :98%Couleur et forme :SolidPD-L1-IN-7
CAS :PD-L1-IN-7 (compound CB31) serves as a PD-L1 inhibitor, effectuating PD-L1 internalization and retention within cells. It restrains the PD-1/PD-L1 interaction (IC 50: 0.2 nM), alters glycosylation patterns, and facilitates PD-L1 degradation. Additionally, PD-L1-IN-7 enhances T cell infiltration, boosts T cell function, and augments the capacity to destroy tumor cells.Formule :C46H50N6O7Couleur et forme :SolidMasse moléculaire :798.93BET/Aurora kinase-IN-1
CAS :BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.Formule :C25H30FN7OCouleur et forme :SolidMasse moléculaire :463.555-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS :5-ETHYL-4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE targets PLK1.Formule :C8H13N3SDegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :183.27PD-1/PD-L1 inhibitory peptide C8
PD-1/PD-L1 inhibitory peptide C8 disrupts the PD-1/PD-L1 interaction, leading to the activation of CD8+ and CD4+ T cells and an increase in IFN-γ secretion. In mouse models, PD-1/PD-L1 inhibitory peptide C8 has demonstrated antitumor activity.Formule :C51H72N14O14S2Couleur et forme :SolidMasse moléculaire :1169.33MRK-952
MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.Formule :C20H20ClF3N6Couleur et forme :SolidMasse moléculaire :436.861CKK-E12
CAS :CKK-E12 is an ionizable lipid for RNA delivery via lipid nanoparticles, with high liver cell selectivity in vivo.Formule :C60H120N4O6Degré de pureté :98.328%Couleur et forme :SolidMasse moléculaire :993.62AZA197
CAS :AZA197 (AZA-197) is a selective Cdc42 inhibitor.Formule :C24H36N6Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :408.58Lobucavir
CAS :Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).Formule :C11H15N5O3Couleur et forme :SolidMasse moléculaire :265.27CCG-257081
CAS :CCG-257081 blocks Rho/MRTF/SRF pathway; prevents fibrosis in mice; useful in cancer and fibrosis research.Formule :C24H19ClF3N3O2Degré de pureté :98% - 99.92%Couleur et forme :SolidMasse moléculaire :473.87TCS7010
CAS :TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.Formule :C31H31ClFN7O2Degré de pureté :98.49% - 99.62%Couleur et forme :SolidMasse moléculaire :588.07Risdiplam
CAS :Risdiplam (RG7916) is a centrally and peripherally distributed and orally administrable small molecule SMN2 pre-mRNA splicing modifier.Cost-effective and quality-assured.Formule :C22H23N7ODegré de pureté :98.68% - 99.43%Couleur et forme :SolidMasse moléculaire :401.46GSK3335103
CAS :GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59(S)-DI-87
CAS :(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor,reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.Formule :C23H30N6O3S2Degré de pureté :99.42%Couleur et forme :SoildMasse moléculaire :502.65Ref: TM-T39550L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€KWR095
CAS :KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.Formule :C33H31ClF3N9O4Couleur et forme :SolidMasse moléculaire :710.105Thymectacin
CAS :Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.Formule :C21H25BrN3O9PDegré de pureté :98.41% - 99.82%Couleur et forme :SolidMasse moléculaire :574.32Voruciclib
CAS :Voruciclib: oral, selective CDK inhibitor (Ki: 0.626-9.1 nM), reduces MCL-1, targets CDK9 in diffuse large B-cell lymphoma.Formule :C22H19ClF3NO5Degré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :469.84CDK4/6-IN-6
CAS :CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.Formule :C22H27ClFN5O3Degré de pureté :95.63%Couleur et forme :SolidMasse moléculaire :463.93Ref: TM-T39957
Produit arrêtéDNA polymerase-IN-3
CAS :DNA polymerase-IN-3 (Compd 5b), a coumarin derivative, demonstrates inhibitory activity against Taq DNA polymerase and has potential applications inFormule :C13H12O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :232.23ARB-272572 hydrochloride
CAS :ARB-272572 hydrochloride is a PD-L1 inhibitor that inhibits PD-1/PD-L1 cell signaling by inducing PD-L1 protein homology interactions.Formule :C32H36N6O4·xClHDegré de pureté :99%Couleur et forme :SoildMasse moléculaire :568.68(Free base)5-OHdU
CAS :5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.Formule :C9H12N2O6Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :244.2Ref: TM-T19152
1mg47,00€2mg60,00€5mg89,00€10mg131,00€25mg212,00€50mg316,00€100mg474,00€1mL*10mM (DMSO)90,00€Palbociclib
CAS :Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.Formule :C24H29N7O2Degré de pureté :98% - 99.9%Couleur et forme :SolidMasse moléculaire :447.53Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Formule :C10H10ClFN5Na3O9P2Couleur et forme :SolidMasse moléculaire :529.58BRD9876
CAS :BRD9876 is a selective inhibitor of MM1S growth.Formule :C16H14N2Degré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :234.3Bractoppin
CAS :Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibitsFormule :C25H23FN4ODegré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :414.47Ref: TM-T8873
1mg49,00€5mg104,00€10mg166,00€25mg325,00€50mg490,00€100mg737,00€500mg1.483,00€1mL*10mM (DMSO)115,00€Werner syndrome RecQ helicase-IN-4
CAS :Werner syndrome RecQ helicase-IN-4 is a WRN inhibitor with anticancer and anti-proliferative activity, used in colorectal and gastric cancer research.Formule :C32H33F3N8O5Degré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :666.65YKL-5-124
CAS :YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displaysFormule :C28H33N7O3Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :515.61Ref: TM-T22461
1mg96,00€2mg135,00€5mg188,00€10mg341,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)225,00€SNX7
CAS :SNX7 (WAY-323879) inhibits CDKI pathway; useful for studying aging and related diseases.Formule :C15H14N2ODegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :238.28MIRA-1
CAS :MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activityFormule :C8H9NO4Degré de pureté :99.38%Couleur et forme :SolidMasse moléculaire :183.16CDK4/6/1 Inhibitor
CAS :CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM).Formule :C28H30F2N6Degré de pureté :97.99% - 99.26%Couleur et forme :SolidMasse moléculaire :488.57TAK-632
CAS :TAK-632 is a potent pan-Raf inhibitor.Formule :C27H18F4N4O3SDegré de pureté :98% - 98.92%Couleur et forme :SolidMasse moléculaire :554.52bio-THZ1
CAS :bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).Formule :C52H65ClN12O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1053.67Roxifiban acetate
CAS :Roxifiban acetate(DMP 754 acetate) is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used inFormule :C23H33N5O8Degré de pureté :99.33% - 99.56%Couleur et forme :SolidMasse moléculaire :507.54CDK2-IN-31
CAS :CDK2-IN-31 (compound I-125A) is an inhibitor of CDK2 and is utilized in cancer research.Formule :C37H52N6O5Couleur et forme :SolidMasse moléculaire :660.85Levomefolate calcium
CAS :Levomefolate calcium is an artificial form of folate. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.Formule :C20H23CaN7O6Degré de pureté :97.35% - 98%Couleur et forme :Off-White To Pale Yellow SolidMasse moléculaire :497.52Deoxycytidine triphosphate trisodium salt
CAS :Deoxycytidine triphosphate trisodium salt (2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE TRISODI) contributes to antibiotic lethality in stationary-phase mycobacteria.Formule :C9H13N3Na3O13P3Degré de pureté :99.80%Couleur et forme :SolidMasse moléculaire :533.1ZYN57939
CAS :ZYN57939 (MTR-106), an RNA polymerase I inhibitor, treats related diseases with a 0.855 μM IC50 against HT-29 cells.Formule :C28H27N7O2SDegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :525.62Trifluridine/tipiracil hydrochloride mixture
CAS :Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and Tipiracil hydrochloride (TTP) in aFormule :C29H34Cl2F6N8O12Degré de pureté :99.37% - ≥98%Couleur et forme :SolidMasse moléculaire :871.53Ref: TM-T3658
2mg39,00€5mg57,00€10mg87,00€25mg157,00€50mg250,00€100mg378,00€200mg568,00€500mg889,00€1mL*10mM (DMSO)78,00€PD173952
CAS :PD173952 is a Src kinase and Myt1 inhibitor with antitumor activity, inhibits Lyn, Abl and Csk, and induces Bcr-Abl-dependent hematopoietic cell apoptosis.Formule :C24H21Cl2N5O2Degré de pureté :99.5%Couleur et forme :SolidMasse moléculaire :482.36BMS-3
CAS :BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.Formule :C17H12Cl2F2N4OSDegré de pureté :99.19% - 99.31%Couleur et forme :SolidMasse moléculaire :429.27Avotaciclib
CAS :Avotaciclib (BEY1107) is a potent and orally active cyclin dependent kinase 1 (CDK1) inhibitor.Avotaciclib can be used to study locally advanced or metastaticFormule :C13H11N7ODegré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :281.27