PKC
Les inhibiteurs de la protéine kinase C (PKC) ciblent la famille des kinases PKC, qui sont impliquées dans un large éventail de processus cellulaires, notamment la régulation du cycle cellulaire, l'apoptose et la différenciation. La PKC joue un rôle clé dans les voies de transduction du signal qui influencent la prolifération et la survie des cellules. L'inhibition de la PKC peut entraîner des changements dans la progression du cycle cellulaire, ce qui rend ces inhibiteurs précieux dans la recherche sur le cancer, la neurobiologie et les maladies cardiovasculaires. Chez CymitQuimica, nous offrons une sélection diversifiée d'inhibiteurs de PKC de haute qualité pour soutenir vos recherches en transduction du signal, régulation du cycle cellulaire et développement thérapeutique.
Produits appartenant à la catégorie "PKC"
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Protein Kinase C (19-31)
CAS :Protein Kinase C (19-31), a PKC inhibitor derived from PKCa, has a serine at position 25 and tests PKC activity.Formule :C67H118N26O16Degré de pureté :98%Couleur et forme :Lyophilized PowderMasse moléculaire :1543.82Psychosine
CAS :Psychosine (Galactosylsphingosine) is a PKC inhibitor, and is highly cytotoxic, inducing cell death in a variety of cells.Formule :C24H47NO7Degré de pureté :98%Couleur et forme :White PowderMasse moléculaire :461.63Bisindolylmaleimide VIII acetate
CAS :Bisindolylmaleimide VIII acetate is a selective PKC inhibitor with an IC50 of 158 nM in rat brain and varying IC50s for different PKC isoforms.Formule :C26H26N4O4Degré de pureté :99.27%Couleur et forme :SolidMasse moléculaire :458.51LY 379196
LY 379196, a potent PKC-β inhibitor (IC 50: 50 nM for PKC βI and 30 nM for PKC βII), effectively suppresses the proliferation of bovine retinal microvascular endothelial cells (BREC) induced by VEGF, IGF-1, and bFGF. This compound serves as an antiproliferative agent for proliferative retinopathy.Formule :C30H34N4O5SCouleur et forme :SolidMasse moléculaire :562.68Mitoxantrone
CAS :Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.Formule :C22H28N4O6Degré de pureté :97.97% - 98.74%Couleur et forme :Blue PowderMasse moléculaire :444.48DCPLA-ME
CAS :DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerativeFormule :C21H38O2Degré de pureté :98.16%Couleur et forme :SolidMasse moléculaire :322.53Ref: TM-T10980
1mg65,00€5mg133,00€10mg180,00€25mg369,00€50mg605,00€100mg815,00€200mg1.111,00€1mL*10mM (DMSO)145,00€PKC β pseudosubstrate acetate
PKC β pseudosubstrate acetate (PKC β pseudosubstrate acetate (172308-76-8 Free base)) is a selective cell-permeable inhibitor of PKC.Degré de pureté :95.01%Couleur et forme :SoildSotrastaurin
CAS :Sotrastaurin (AEB071) is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ).Formule :C25H22N6O2Degré de pureté :98% - 99.70%Couleur et forme :SolidMasse moléculaire :438.48Ref: TM-T6278
1mg49,00€5mg96,00€10mg166,00€25mg313,00€50mg553,00€100mg790,00€500mg1.578,00€1mL*10mM (DMSO)115,00€YM-53601
CAS :YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.Formule :C21H22ClFN2ODegré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :372.86Protein Kinase C (19-31) (TFA)(121545-65-1,free)
Protein Kinase C (19-31) TFA is a serine-modified PKCa-derived inhibitor for testing PKC activity.Formule :C69H119F3N26O18Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1657.84Bisindolylmaleimide V
CAS :Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.Formule :C21H15N3O2Degré de pureté :90%Couleur et forme :Red SolidMasse moléculaire :341.36Mitoxantrone dihydrochloride
CAS :Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.Formule :C22H30Cl2N4O6Degré de pureté :100% - 99.85%Couleur et forme :Blue-Black Solid From Water Ethanol SolidMasse moléculaire :517.4Desmethylglycitein
CAS :Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFormule :C15H10O5Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :270.24Ref: TM-TN1299
1mg178,00€5mg540,00€10mg715,00€25mg1.103,00€50mg1.491,00€100mg2.005,00€500mg4.010,00€1mL*10mM (DMSO)442,00€PKCβ inhibitor 1
CAS :PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,Formule :C24H21N5O2Degré de pureté :99.33%Couleur et forme :SolidMasse moléculaire :411.46Ref: TM-T8376
1mg154,00€5mg424,00€10mg605,00€25mg920,00€50mg1.216,00€100mg1.673,00€200mg2.252,00€500µg93,00€1mL*10mM (DMSO)401,00€Ingenol
CAS :Ingenol mebutate treats actinic keratosis, has anticancer properties, and may reactivate latent HIV.Formule :C20H28O5Degré de pureté :99.78% - 99.87%Couleur et forme :SolidMasse moléculaire :348.43Ref: TM-T5S2017
1mg52,00€5mg95,00€10mg127,00€25mg246,00€50mg467,00€100mg640,00€500mg1.359,00€1mL*10mM (DMSO)96,00€Darovasertib
CAS :Darovasertib (LXS196) is a potent PKC inhibitor, orally active, with IC50 of 1.9 nM (PKCα), 0.4 nM (PKCθ), 3.1 μM (GSK3β).Formule :C22H23F3N8ODegré de pureté :98.72% - ≥95%Couleur et forme :SolidMasse moléculaire :472.47Ref: TM-T5600
1mg52,00€5mg136,00€10mg188,00€25mg350,00€50mg522,00€100mg750,00€200mg1.026,00€1mL*10mM (DMSO)149,00€Procyanidin A1
CAS :Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+.Formule :C30H24O12Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :576.5Taurochenodeoxycholic Acid
CAS :Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Formule :C26H45NO6SDegré de pureté :99.69% - 99.86%Couleur et forme :SolidMasse moléculaire :499.7Afuresertib
CAS :Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFormule :C18H17Cl2FN4OSDegré de pureté :97.51% - 99.17%Couleur et forme :SolidMasse moléculaire :427.32Ref: TM-T1911
1mg39,00€2mg50,00€5mg79,00€10mg97,00€25mg170,00€50mg274,00€100mg477,00€500mg1.035,00€1mL*10mM (DMSO)79,00€Ζ-Stat
CAS :ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis inFormule :C10H8O10S3Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :384.36
