Récepteur des androgènes
Le récepteur aux androgènes (AR) est un récepteur hormonal nucléaire activé par la liaison aux androgènes, tels que la testostérone et la dihydrotestostérone. Ce récepteur joue un rôle crucial dans le développement et le maintien des caractéristiques masculines, ainsi que dans la régulation de plusieurs processus physiologiques, notamment la croissance musculaire, la libido et la densité osseuse. Les inhibiteurs du récepteur aux androgènes sont largement étudiés dans le contexte du cancer de la prostate, où la signalisation de l'AR est souvent régulée à la hausse. Chez CymitQuimica, nous offrons une gamme de modulateurs du récepteur aux androgènes de haute qualité pour soutenir vos recherches en endocrinologie, biologie du cancer et régulation hormonale.
Produits appartenant à la catégorie "Récepteur des androgènes"
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AR antagonist 10
CAS :AR antagonist 10 (Compound Y5) is a potent, orally active androgen receptor (AR) antagonist with an IC50 value of 0.04 μM. It demonstrates a dual mechanism of action: antagonizing AR by disrupting AR dimerization and inducing AR degradation through the ubiquitin-proteasome pathway. This compound shows excellent activity against various resistant AR mutants and effectively inhibits the growth of LNCaP xenograft tumors. AR antagonist 10 is applicable for research in resistant prostate cancer.Formule :C18H17ClN4O3SCouleur et forme :SolidMasse moléculaire :404.871Dehydroisoandrosterone 3-acetate
CAS :Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.Formule :C21H30O3Degré de pureté :100% - 99.81%Couleur et forme :SolidMasse moléculaire :330.46ONC1-13B
CAS :ONC1-13B, an androgen receptor antagonist, is used potentially for the treatment of prostate cancer.Formule :C22H16F4N4O3SDegré de pureté :99.45% - 99.85%Couleur et forme :SolidMasse moléculaire :492.45ARD-2585
CAS :ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.Formule :C41H43ClN8O5Couleur et forme :SolidMasse moléculaire :763.28LY2452473
CAS :LY2452473 (OPK 88004) is an orally available and selective androgen receptor modulator with potential anticancer activity for the study of prostate cancer.Formule :C22H22N4O2Degré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :374.44Ref: TM-T15804
1mg35,00€5mg74,00€10mg97,00€25mg149,00€50mg188,00€100mg281,00€200mg429,00€1mL*10mM (DMSO)81,00€p,p'-DDE
CAS :p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDTFormule :C14H8Cl4Degré de pureté :99.68%Couleur et forme :White Crystalline Solid Physical Description White Crystalline Solid Or White Powder (Ntp 1992)Masse moléculaire :318.03Androgen receptor antagonist 12
CAS :Compound EF2 (Androgen receptor antagonist 12) is an orally active antagonist of the androgen receptor (AR) with an IC50 of 0.30 µM. It inhibits the transcriptional activity of mutant AR and the proliferation of AR-positive PCa (prostate cancer) cell lines. Additionally, Compound EF2 blocks the nuclear translocation of AR and suppresses tumor growth in the C4-2B xenograft mouse model. This compound is used for research in prostate cancer.Formule :C12H8F3N3O2Couleur et forme :SolidMasse moléculaire :283.21LX1
CAS :LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.Formule :C22H15F6NO2Couleur et forme :SolidMasse moléculaire :439.35CTK8A3536
CAS :CTK8A3536 ((2-MORPHOLIN-4-YL-4-PHENYL-1,3-THIAZOL-5-YL)METHANOL) is an inhibitor of Androgen receptor.Formule :C14H16N2O2SDegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :276.35Ref: TM-T8592
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)169,00€Pentomone
CAS :Pentomone (LY-113935) is an anti-androgen compound that acts as a prostate growth inhibitor.Formule :C24H26O5Couleur et forme :SolidMasse moléculaire :394.46Zanoterone
CAS :Zanoterone is an AR antagonist (androgen receptor).Zanoterone has antitumor activity for the treatment of genitourinary disorders and oncological disorders andFormule :C23H32N2O3SDegré de pureté :99.85% - 99.96%Couleur et forme :SoildMasse moléculaire :416.58Bavdegalutamide
CAS :Bavdegalutamide (ARV-110) is a PROTAC degrader of androgen receptor (AR).Formule :C41H43ClFN9O6Degré de pureté :97.17% - 99.04%Couleur et forme :SolidMasse moléculaire :812.29ARD-2128
CAS :ARD-2128: potent oral PROTAC that degrades AR, curbing prostate cancer growth with no toxicity.Formule :C45H50ClN7O6Degré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :820.37Bifluranol
CAS :Bifluranol (BX341) has anti-androgenic activity and has shown significant anti-prostatic activity in in vivo studies for the treatment of benign prostaticFormule :C17H18F2O2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :292.32Gridegalutamide
CAS :Gridegalutamide exhibits anti-androgen and anti-tumor activities.Formule :C41H45F3N8O5SCouleur et forme :SolidMasse moléculaire :818.91Vosilasarm
CAS :RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.Formule :C20H16ClN5O2Degré de pureté :99.01% - 99.6%Couleur et forme :A Crystalline SolidMasse moléculaire :393.82(+)-JJ-74-138
CAS :(+)-JJ-74-138 is a novel non-competitive androgen receptor (AR) antagonist capable of inhibiting enzalutamide-resistant castration-resistant prostate cancer (CRPC).Formule :C22H22F8N2OSCouleur et forme :SolidMasse moléculaire :514.48YXG-158
CAS :YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1Formule :C30H36FN3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :473.62ACP-105
CAS :ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgenFormule :C16H19ClN2ODegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :290.79Ref: TM-T14116
2mg38,00€5mg58,00€10mg90,00€25mg164,00€50mg226,00€100mg325,00€200mg455,00€1mL*10mM (DMSO)65,00€MI-136
CAS :MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.Formule :C23H21F3N6SDegré de pureté :97.08% - 98.63%Couleur et forme :SolidMasse moléculaire :470.51Ref: TM-T6889
1mg47,00€5mg87,00€10mg147,00€25mg279,00€50mg472,00€100mg730,00€200mg1.017,00€1mL*10mM (DMSO)97,00€
