NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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NLRP3 agonist 1
CAS :Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.Formule :C15H16N6Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :280.33Salicortin
CAS :Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.Formule :C20H24O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :424.40GGTI 2147
CAS :GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Formule :C28H30N4O3Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :470.56BEC hydrochloride
CAS :BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.Formule :C5H12BNO4S·ClHDegré de pureté :98.65% - 99.28%Couleur et forme :SolidMasse moléculaire :229.49Ref: TM-T6779
1mg39,00€2mg49,00€5mg88,00€10mg153,00€25mg283,00€50mg535,00€100mg747,00€1mL*10mM (DMSO)88,00€Sanggenon A
CAS :Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and itFormule :C25H24O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :436.45Narlumosbart
CAS :Narlumosbart (JMT103) is an IgG4κ monoclonal antibody that selectively binds to the receptor activator of nuclear factor-κB ligand (RANKL)[1].Degré de pureté :98%Couleur et forme :LiquidRIPK1-IN-19
CAS :RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.Formule :C28H25FN6O2Degré de pureté :98.81%Couleur et forme :SolidMasse moléculaire :496.54PK68
CAS :PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Formule :C22H24N4O3SDegré de pureté :98.09% - 98.13%Couleur et forme :SolidMasse moléculaire :424.52Ref: TM-T12493
1mg86,00€5mg170,00€10mg274,00€25mg520,00€50mg750,00€100mg1.026,00€200mg1.388,00€1mL*10mM (DMSO)188,00€IMD-biphenylA
CAS :IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFormule :C35H33N5O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :555.67(Rac)-BAY-985
CAS :(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Formule :C27H30F3N9ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :553.58DCZ0415
CAS :DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Formule :C23H20N2O2Degré de pureté :99.34%Couleur et forme :SolidMasse moléculaire :356.42Ref: TM-T10981
1mg52,00€5mg116,00€10mg188,00€25mg354,00€50mg588,00€100mg873,00€1mL*10mM (DMSO)126,00€Kukoamine A
CAS :Kukoamine A: anticancer, cytoprotective, antioxidant, anti-inflammatory, inhibits trypanothione reductase (mixed inhibitor, Ki=1.8µM).Formule :C28H42N4O6Degré de pureté :97.45% - 99.28%Couleur et forme :SolidMasse moléculaire :530.66Ginsenoside Rk1
CAS :Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Formule :C42H70O12Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :767IRAK4-IN-1
CAS :IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.Formule :C19H23N5ODegré de pureté :98.18% - 99.74%Couleur et forme :SolidMasse moléculaire :337.42Dihydroartemisinin
CAS :Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.Formule :C15H24O5Degré de pureté :99.41% - 99.72%Couleur et forme :White SolidMasse moléculaire :284.35Aspirin
CAS :Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Formule :C9H8O4Degré de pureté :99.78% - 99.91%Couleur et forme :White Solid CrystallineMasse moléculaire :180.16IRAK4-IN-7
CAS :IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.Formule :C21H19N7O3Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :417.42Ref: TM-T5354
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg210,00€50mg354,00€100mg528,00€1mL*10mM (DMSO)87,00€Ginsenoside Rg1
CAS :Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng).Formule :C42H72O14Degré de pureté :99% - 99.74%Couleur et forme :White Crystalline PowderMasse moléculaire :801.01Vamorolone
CAS :Vamorolone (VBP15) is a steroid-like drug that treats muscular dystrophy with fewer side effects and inhibits NF-κB.Formule :C22H28O4Degré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :356.46Ref: TM-T17217
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg188,00€50mg298,00€100mg444,00€200mg640,00€1mL*10mM (DMSO)87,00€Mollugin
CAS :Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.Formule :C17H16O4Degré de pureté :98.31% - ≥95%Couleur et forme :SolidMasse moléculaire :284.31
