
NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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Supercinnamaldehyde
CAS :Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ionFormule :C12H11NO2Degré de pureté :98.89%Couleur et forme :SolidMasse moléculaire :201.22Stachydrine
CAS :Stachydrine, found in leonurus herb, aids blood flow, blocks NF-κB pathway, and indicates citrus intake.Formule :C7H13NO2Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :143.18OPHIOPOGONIN D
CAS :Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.Formule :C44H70O16Degré de pureté :99.46% - ≥95%Couleur et forme :SolidMasse moléculaire :855.02Ergolide
CAS :Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Formule :C17H22O5Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :306.35Ref: TM-T13686
1mg74,00€5mg146,00€10mg243,00€25mg394,00€50mg548,00€100mg735,00€1mL*10mM (DMSO)170,00€Nitidine chloride
CAS :1.Formule :C21H18ClNO4Degré de pureté :96.59% - 98.91%Couleur et forme :SolidMasse moléculaire :383.82IRAK inhibitor 1
CAS :IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).Formule :C17H19N5Degré de pureté :100% - 97.78%Couleur et forme :SolidMasse moléculaire :293.37Ref: TM-T5094
1mg95,00€2mg125,00€5mg202,00€10mg283,00€25mg472,00€50mg687,00€100mg938,00€1mL*10mM (DMSO)135,00€Erdosteine
CAS :Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.Formule :C8H11NO4S2Degré de pureté :99.43% - 99.94%Couleur et forme :White Or Almost White Crystalline PowderMasse moléculaire :249.31CTP-NBD
CAS :CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].Formule :C121H194N46O32Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :2805.12Phorbol 12-myristate 13-acetate
CAS :Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Formule :C36H56O8Degré de pureté :100% - 99.5%Couleur et forme :White To Off-White SolidMasse moléculaire :616.83Mevastatin
CAS :Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Formule :C23H34O5Degré de pureté :99.12%Couleur et forme :White-Yellowish To Yellow Powder Solid PowderMasse moléculaire :390.51Muramyl dipeptide
CAS :MDP is a synthetic peptide promoting bone formation by modulating osteoclasts, osteoblasts, and Runx2 expression via MAPK pathways.Formule :C19H32N4O11Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :492.48Ref: TM-T16159
1mg88,00€5mg178,00€10mg279,00€25mg545,00€50mg777,00€100mg1.064,00€200mg1.415,00€1mL*10mM (DMSO)188,00€Bay 11-7085
CAS :Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).Formule :C13H15NO2SDegré de pureté :99.76% - 99.83%Couleur et forme :White SolidMasse moléculaire :249.33Ref: TM-T1934
2mg35,00€5mg50,00€10mg66,00€25mg85,00€50mg124,00€100mg197,00€200mg255,00€1mL*10mM (DMSO)62,00€Andrographolide
CAS :Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potentialFormule :C20H30O5Degré de pureté :100% - 99.97%Couleur et forme :PowderMasse moléculaire :350.45Delanzomib
CAS :Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Formule :C21H28BN3O5Degré de pureté :95.52% - 99.46%Couleur et forme :SolidMasse moléculaire :413.28Ref: TM-T6027
1mg46,00€5mg96,00€10mg140,00€25mg274,00€50mg439,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)95,00€IRAK4-IN-4
CAS :IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4)Formule :C22H16N2O2Degré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :340.37Ref: TM-T11673
1mg64,00€5mg145,00€10mg212,00€25mg378,00€50mg567,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)160,00€Demethyleneberberine chloride
CAS :Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Formule :C19H18ClNO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :359.8RIPK1-IN-4
CAS :RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50sFormule :C23H23N5O2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :401.46DMAPT
CAS :DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Formule :C17H27NO3Degré de pureté :100.00%Couleur et forme :SolidMasse moléculaire :293.4Triptolide
CAS :Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.Formule :C20H24O6Degré de pureté :97.19% - 99.97%Couleur et forme :White To Off-White SolidMasse moléculaire :360.4Ref: TM-T2179
1mg44,00€2mg58,00€5mg96,00€10mg137,00€25mg310,00€50mg462,00€100mg553,00€1mL*10mM (DMSO)85,00€Tomatidine
CAS :Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Formule :C27H45NO2Degré de pureté :98.38% - 99.98%Couleur et forme :SolidMasse moléculaire :415.65