
NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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Sodium Aescinate
CAS :Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.Formule :C54H83NaO23Degré de pureté :95.17%Couleur et forme :SolidMasse moléculaire :1123.21Dehydrodiisoeugenol
CAS :Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.Formule :C20H22O4Degré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :326.39Deoxyelephantopin
CAS :Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Formule :C19H20O6Degré de pureté :99.6% - 99.71%Couleur et forme :SolidMasse moléculaire :344.36EUK-134
CAS :EUK-134, a synthetic SOD/catalase mimetic, exhibits potent antioxidant activities, and inhibits the formation of β-amyloid and related amyloid fibril.Formule :C18H18ClMnN2O4Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :416.74Ref: TM-T6495
10mg35,00€25mg66,00€50mg104,00€100mg160,00€200mg230,00€500mg378,00€1mL*10mM (DMSO)47,00€GSK-872
CAS :GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity and inhibits kinase activity.Formule :C19H17N3O2S2Degré de pureté :99.3%Couleur et forme :SolidMasse moléculaire :383.49Ref: TM-T4074
1mg38,00€5mg79,00€10mg119,00€25mg188,00€50mg321,00€100mg494,00€200mg705,00€1mL*10mM (DMSO)86,00€Anatabine dicitrate
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier.Formule :C22H28N2O14Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :544.46Necrostatin-34
CAS :Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying aFormule :C18H16N4O2S2Degré de pureté :98.66% - 98.80%Couleur et forme :SolidMasse moléculaire :384.48Ref: TM-T9095
1mg52,00€5mg116,00€10mg170,00€25mg305,00€50mg442,00€100mg615,00€200mg832,00€1mL*10mM (DMSO)135,00€HOIPIN-1
CAS :HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-Formule :C17H13NaO4Degré de pureté :98.83%Couleur et forme :SoildMasse moléculaire :304.27Mangiferin
CAS :Mangiferin (Hedysarid) is used for antidiabetes. Extracted from Mangifera indica L.Formule :C19H18O11Degré de pureté :96.74% - 98.30%Couleur et forme :Light Yellow PowderMasse moléculaire :422.34Anti-inflammatory agent 48
Anti-inflammatory agent 48 functions by inhibiting the NF-κB signaling pathway and activating HO-1 expression, characterizing its role as an anti-inflammatoryFormule :C24H21Cl2NO3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :442.33CIB-1476
CIB-1476, a caspase-1 inhibitor, effectively reduces joint swelling in mouse models of arthritis and demonstrates lasting anti-inflammatory effects. This compound achieves its benefits by blocking IL-1β production, NF-κB activation, and GSDMD-mediated pyroptosis, all of which are triggered by the NLRP3 inflammasome.Formule :C28H28N2O6SCouleur et forme :SolidMasse moléculaire :520.6GTCpFE
CAS :GTCpFE, a compound synthesized from Dimethyl fumarate (DMF) and Aspirin (ASA), inhibits IKKα/β in the NF-κB pathway, exhibiting anti-inflammatory activity by preventing p65 from entering the nucleus. It selectively inhibits cancer stem cell (CSC) activity by reducing the growth of mammospheres and the expression of the CD44+CD24- immune phenotype. Furthermore, GTCpFE targets breast cancer stem cells, crucial in aggressive cancer phenotypes that depend on NFκB and PGE2.Formule :C22H20O8Couleur et forme :SolidMasse moléculaire :412.39Oxaprozin
CAS :Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug.Formule :C18H15NO3Degré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :293.32Rucaparib Phosphate
CAS :Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP that is used in clinical therapy to sensitize cancer cells to chemotherapy.Formule :C19H18FN3O·H3PO4Degré de pureté :99.1%Couleur et forme :SolidMasse moléculaire :421.36Ref: TM-T6127
1mg38,00€2mg49,00€5mg79,00€10mg115,00€25mg188,00€50mg248,00€100mg393,00€200mg585,00€1mL*10mM (DMSO)79,00€Dehydroevodiamine
CAS :Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressantFormule :C19H15N3ODegré de pureté :99.54%Couleur et forme :SolidMasse moléculaire :301.34GSK583
CAS :GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).Formule :C20H19FN4O2SDegré de pureté :98.68% - 99.06%Couleur et forme :SolidMasse moléculaire :398.45Ref: TM-T3537
1mg50,00€2mg71,00€5mg116,00€10mg190,00€25mg319,00€50mg465,00€100mg690,00€500mg1.444,00€1mL*10mM (DMSO)116,00€Moslosooflavone
CAS :Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.Formule :C17H14O5Degré de pureté :98% - 99.78%Couleur et forme :SolidMasse moléculaire :298.29IKK2-IN-4
CAS :IKK2-IN-4(IKK2 Inhibitor VI) is a highly potent IKK-2 inhibitor with an IC50 value of 25 nM. IKK2-IN-4 inhibited the production of TNF-α in PBMC induced by LPS.Formule :C12H11N3O2SDegré de pureté :100%Couleur et forme :SolidMasse moléculaire :261.3Ref: TM-T36524
1mg163,00€5mg395,00€10mg605,00€25mg938,00€50mg1.264,00€100mg1.700,00€200mg2.270,00€500µg111,00€Astilbin
CAS :Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.Formule :C21H22O11Degré de pureté :97% - 99.76%Couleur et forme :White PowderMasse moléculaire :450.39Ref: TM-T2794
5mg52,00€10mg77,00€25mg140,00€50mg224,00€100mg334,00€200mg477,00€500mg778,00€1mL*10mM (DMSO)51,00€Rucaparib monocamsylate
CAS :Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor. Rucaparib Camsylate also displays binding affinity to eight other PARP domains.Formule :C29H34FN3O5SDegré de pureté :99.82%Couleur et forme :SolidMasse moléculaire :555.66Ref: TM-T16807
5mg60,00€10mg96,00€25mg160,00€50mg235,00€100mg354,00€200mg522,00€1mL*10mM (DMSO)74,00€