
NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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11-Keto-β-boswellic acid
CAS :11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor, exerts dose dependent cardioprotective effect manifested.Formule :C30H46O4Degré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :470.68Ref: TM-TN1182
1mg60,00€5mg137,00€10mg210,00€25mg356,00€50mg525,00€100mg750,00€1mL*10mM (DMSO)140,00€RIPA-56
CAS :RIPA-56 is an inhibitor of RIP1Formule :C13H19NO2Degré de pureté :99.53% - 99.95%Couleur et forme :SolidMasse moléculaire :221.3Ref: TM-T7795
5mg38,00€10mg52,00€25mg94,00€50mg136,00€100mg213,00€200mg316,00€500mg532,00€1mL*10mM (DMSO)55,00€oxLig-1
CAS :OxLig-1 (7-Ketocholesteryl-9-carboxynonanoate) constitutes a lipid component of oxidized low-density lipoprotein (oxLDL) and serves as a critical ligand for β-glycoprotein I (β(2)-GPI). It induces nuclear translocation by activating the NF-κB pathway. Additionally, oxLig-1 is utilized in the study of atherosclerosis (AS).Formule :C36H58O5Couleur et forme :SolidMasse moléculaire :570.84N,N-Dimethylacetamide
CAS :N,N-Dimethylacetamide (DMAc) is a drug excipient with anti-inflammatory activity, acting through the inhibition of the NF-κB signaling pathway.Formule :C4H9NODegré de pureté :99.13%Couleur et forme :Colourless LiquidMasse moléculaire :87.12Hentriacontane
CAS :Hentriacontane is a natural product with various pharmacological effects including anti-inflammatory, antitumor, and antimicrobial activities.Formule :C31H64Degré de pureté :95.85%Couleur et forme :SolidMasse moléculaire :436.84NBD peptide
CAS :NBD peptide inhibits the NF-κB signaling pathway by preventing the binding of the NEMO-IKK complex. It exhibits anti-inflammatory activity by blocking the production of pro-inflammatory cytokines. Additionally, NBD peptide demonstrates immunosuppressive effects through the regulation of immune cells. It enhances transmembrane capacity by conjugating with the cell-penetrating peptide HIV-TAT.Formule :C62H88N14O20Couleur et forme :SolidMasse moléculaire :1349.44Ginsenoside Rd
CAS :Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.Formule :C48H82O18Degré de pureté :99.13% - 99.8%Couleur et forme :SolidMasse moléculaire :947.15Ref: TM-T2878
1mg39,00€5mg81,00€10mg127,00€25mg205,00€50mg304,00€100mg455,00€500mg998,00€1mL*10mM (DMSO)131,00€IRAK4-IN-24
IRAK4-IN-24 (compound 16), a potent IRAK4 inhibitor, exhibits high clearance (Cl) and low oral bioavailability.Formule :C19H19N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :365.39Embelin
CAS :Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).Formule :C17H26O4Degré de pureté :97.07% - 99.88%Couleur et forme :SolidMasse moléculaire :294.39RIPK1-IN-27
RIPK1-IN-27 (compound 19) is an inhibitor of RIPK1.Formule :C27H28N4O3Couleur et forme :SolidMasse moléculaire :456.54Schisantherin A
CAS :Schisantherin A, a lignan from Schisandra fruit, is used as an antitussive, tonic, and sedative.Formule :C30H32O9Degré de pureté :98% - 99.96%Couleur et forme :SolidMasse moléculaire :536.57Cudraflavone B
CAS :Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells andFormule :C25H24O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :420.45Sabialimon P
CAS :Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.Formule :C31H50O4Couleur et forme :SolidMasse moléculaire :486.73BAY-985
CAS :BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.Formule :C27H30F3N9ODegré de pureté :99.62%Couleur et forme :SolidMasse moléculaire :553.58Ref: TM-T10477
1mg172,00€5mg354,00€10mg567,00€25mg905,00€50mg1.225,00€100mg1.644,00€1mL*10mM (DMSO)430,00€SU1261
SU1261, an IKK inhibitor, exhibits Ki values of 10 nM for IKKα and 680 nM for IKKβ. It effectively inhibits non-canonical NF-κB signaling in U2OS osteosarcoma cells.Couleur et forme :Odour SolidGLPG2534
CAS :GLPG2534 is an orally active, selective and potent IRAK4 inhibitor with anti-inflammatory activity. GLPG2534 can be used in psoriasis and atopic dermatitis.Formule :C21H24N6O4Degré de pureté :98.89% - 99.61%Couleur et forme :SolidMasse moléculaire :424.45GSK3145095
CAS :GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.Formule :C20H17F2N5O2Degré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :397.38Ref: TM-T15437
1mg96,00€5mg246,00€10mg344,00€25mg553,00€50mg727,00€100mg938,00€1mL*10mM (DMSO)240,00€SC-514
CAS :SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Formule :C9H8N2OS2Degré de pureté :100% - 99.88%Couleur et forme :SolidMasse moléculaire :224.3Ginsenoside Rg5
CAS :Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Formule :C42H70O12Degré de pureté :98% - 98.07%Couleur et forme :SolidMasse moléculaire :767Ref: TM-T6S1487
1mg113,00€5mg265,00€10mg426,00€25mg702,00€50mg938,00€100mg1.320,00€1mL*10mM (DMSO)360,00€Sodium salicylate
CAS :Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.Formule :C7H5NaO3Degré de pureté :99.36% - 99.77%Couleur et forme :White Solid AmorphousMasse moléculaire :160.11