STAT
Les protéines STAT sont des composants critiques de la voie de signalisation JAK/STAT, qui transmet les signaux extracellulaires des cytokines et des facteurs de croissance au noyau cellulaire, influençant ainsi l'expression génique. Les protéines STAT sont impliquées dans la régulation des réponses immunitaires, de la croissance cellulaire, de la différenciation et de la survie. La dérégulation de la signalisation STAT est impliquée dans diverses maladies, y compris le cancer, les troubles auto-immuns et l'inflammation chronique. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de la voie STAT pour soutenir vos recherches en transduction de signal, immunologie et développement thérapeutique.
Produits appartenant à la catégorie "STAT"
Trier par
STAT5-IN-1
CAS :STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.Formule :C16H11N3O3Degré de pureté :99.44% - ≥95%Couleur et forme :SolidMasse moléculaire :293.28Antitumor agent-195
Antitumor agent-195 (compound 16c) is a dual-targeting agent that simultaneously targets STAT3 and NQO1. At a concentration of 1 μM, it significantly inhibits the phosphorylation of STAT3 at the Tyr705 site and effectively induces apoptosis in MDA-MB-231 and MDA-MB-468 breast cancer cells. As a substrate of NQO1, Antitumor agent-195 markedly increases ROS production, causing severe DNA damage in a dose-dependent manner. It also demonstrates strong antitumor properties in MDA-MB-231 xenograft models.Formule :C22H22N2O4Couleur et forme :SolidMasse moléculaire :378.42Anticancer agent 259
Anticanceragent 259 (Compound 3g) is a telmisartan-based cell death regulator that disrupts the STAT5 signaling pathway, thereby increasing the sensitivity of resistant cells to imatinib, with an SC50 of 1.5 μM.Formule :C30H26N2O2Couleur et forme :SolidMasse moléculaire :446.54Mogrol
CAS :Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formule :C30H52O4Degré de pureté :98.21% - 99.85%Couleur et forme :SolidMasse moléculaire :476.73Ref: TM-TN2346
1mg37,00€5mg74,00€10mg111,00€25mg180,00€50mg269,00€100mg399,00€500mg905,00€1mL*10mM (DMSO)79,00€SH-4-54
CAS :SH-4-54 is a most potent, small molecule, nonphosphorylated STAT3 inhibitor.Formule :C29H27F5N2O5SDegré de pureté :98% - 99.12%Couleur et forme :SolidMasse moléculaire :610.59Ref: TM-T6669
1mg50,00€2mg66,00€5mg96,00€10mg160,00€25mg311,00€50mg502,00€100mg730,00€1mL*10mM (DMSO)135,00€Compound SC-1
CAS :SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib.Formule :C21H13ClF3N3O2Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :431.8Ref: TM-T22424
1mg90,00€5mg160,00€10mg245,00€25mg444,00€50mg638,00€100mg848,00€200mg1.121,00€1mL*10mM (DMSO)178,00€Stafib-1
CAS :Stafib-1 is a selective inhibitor of STAT5β targeting SH2 domain with an IC50 of 154 nM and a Ki of 44 nM.Formule :C26H24N2O11P2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :602.42Napabucasin
CAS :Napabucasin (BBI608) is an orally available Stat3 and Y cell stemness inhibitor.Formule :C14H8O4Degré de pureté :98.43% - 99.61%Couleur et forme :SolidMasse moléculaire :240.21Angoline
CAS :Angoline hydrochloride: IL6/STAT3 inhibitor, IC50: 11.56 μM, blocks STAT3 phosphorylation and cancer cell growth.Formule :C22H21NO5Degré de pureté :99.43% - 99.96%Couleur et forme :SolidMasse moléculaire :379.41Ref: TM-TN6739
1mg66,00€5mg144,00€10mg207,00€25mg344,00€50mg512,00€100mg740,00€1mL*10mM (DMSO)158,00€AG490
CAS :AG490 inhibits EGFR (0.1 μM IC50), 135x > selective than ErbB2, blocks JAK2, spares Lyn, Lck, Syk, Btk, Src.Formule :C17H14N2O3Degré de pureté :98.6% - 99.39%Couleur et forme :Yellow SolidMasse moléculaire :294.3HODHBt
CAS :HODHBt is a STAT5-SUMO protein-protein interaction inhibitor.Formule :C7H5N3O2Degré de pureté :99.45% - 99.95%Couleur et forme :Off-White To Yellow SolidMasse moléculaire :163.13Ascochlorin
CAS :Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.Formule :C23H29ClO4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :404.93Diosgenin
CAS :Diosgenin (Nitogenin) is a spirostan found in DIOSCOREA and other plants.Formule :C27H42O3Degré de pureté :98.87% - 99.87%Couleur et forme :Flaky Or Needle CrystalMasse moléculaire :414.62ML115
CAS :ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.Formule :C15H15ClN2O4Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :322.74Ref: TM-T35544
1mg95,00€5mg227,00€10mg359,00€25mg630,00€50mg882,00€100mg1.188,00€200mg1.596,00€500mg2.357,00€1mL*10mM (DMSO)251,00€STX-0119
CAS :STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.Formule :C22H14N4O3Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :382.37Ref: TM-T60160
5mg64,00€10mg92,00€25mg177,00€50mg283,00€100mg425,00€500mgÀ demander1mL*10mM (DMSO)64,00€HJC0152 hydrochloride
CAS :HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.Formule :C15H14Cl3N3O4Degré de pureté :98.33% - 98.62%Couleur et forme :SolidMasse moléculaire :406.64STAT3-IN-35
CAS :STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain. This compound inhibits the phosphorylation of STAT3 and exhibits antiproliferative activity in triple-negative breast cancer (TNBC) cell lines. Additionally, STAT3-IN-35 has demonstrated toxicity and potent antitumor activity in TNBC xenograft models.Formule :C21H23NO4Couleur et forme :SolidMasse moléculaire :353.41Artesunate
CAS :Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria.Formule :C19H28O8Degré de pureté :99.53% - 99.91%Couleur et forme :White Crystalline PowderMasse moléculaire :384.42TPCA-1
CAS :TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinasesFormule :C12H10FN3O2SDegré de pureté :95.03% - 97.86%Couleur et forme :SolidMasse moléculaire :279.29Curculigoside
CAS :1.Formule :C22H26O11Degré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :466.44
