STAT
Les protéines STAT sont des composants critiques de la voie de signalisation JAK/STAT, qui transmet les signaux extracellulaires des cytokines et des facteurs de croissance au noyau cellulaire, influençant ainsi l'expression génique. Les protéines STAT sont impliquées dans la régulation des réponses immunitaires, de la croissance cellulaire, de la différenciation et de la survie. La dérégulation de la signalisation STAT est impliquée dans diverses maladies, y compris le cancer, les troubles auto-immuns et l'inflammation chronique. Chez CymitQuimica, nous proposons une gamme complète de modulateurs de la voie STAT pour soutenir vos recherches en transduction de signal, immunologie et développement thérapeutique.
Produits appartenant à la catégorie "STAT"
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Stafib-2
CAS :Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM,Formule :C28H26N2O12P2Degré de pureté :98.97%Couleur et forme :SolidMasse moléculaire :644.46Ref: TM-T9646
1mg208,00€5mg518,00€10mg740,00€25mg1.093,00€50mg1.473,00€100mg2.015,00€1mL*10mM (DMSO)737,00€AS2863619
CAS :AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Formule :C16H14Cl2N8ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :405.24Ref: TM-T8378
1mg131,00€2mg180,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)303,00€RO8191
CAS :RO8191 (CDM-3008) (CDM-3008) is an agonist of interferon (IFN) receptor.Formule :C14H5F6N5ODegré de pureté :98.85% - ≥98%Couleur et forme :SolidMasse moléculaire :373.21Atractylenolide I
CAS :Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Formule :C15H18O2Degré de pureté :97.55% - 99.83%Couleur et forme :SolidMasse moléculaire :230.3KT-333
CAS :KT-333 is a potent, highly selective, heterobifunctional degrader of STAT3 for the treatment of a variety of STAT3-dependent pathologies, antitumor.Formule :C60H74ClN10O14PSDegré de pureté :98.12%Couleur et forme :SolidMasse moléculaire :1257.78Tetramethylcurcumin
CAS :Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it alsoFormule :C25H28O6Degré de pureté :99.94% - ≥98%Couleur et forme :SolidMasse moléculaire :424.49PMMB-187
CAS :PMMB-187, a selective STAT3 inhibitor, exhibits an IC50 of 1.81 μM in MDA-MB-231 cells. This compound induces apoptosis in MDA-MB-231 cells by inhibiting STAT3 transcriptional activity and nuclear translocation, reducing mitochondrial membrane potential, increasing reactive oxygen species (ROS) production, and upregulating the expression of apoptosis-related proteins. PMMB-187 is useful for research in the field of cancer.Formule :C27H23BrN2O6S2Couleur et forme :SolidMasse moléculaire :615.52Stafia-1
CAS :Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.Formule :C24H27O10PDegré de pureté :98.08%Couleur et forme :SolidMasse moléculaire :506.44Ref: TM-T9339
1mg86,00€5mg187,00€10mg309,00€25mg525,00€50mg757,00€100mg1.035,00€500mg2.110,00€1mL*10mM (DMSO)217,00€Protosappanin A
CAS :Protosappanin A combats brain inflammation, suppresses rat heart transplant rejection, fights MRSA, and inhibits HIV with a 12.6 uM IC50.Formule :C15H12O5Degré de pureté :100% - 99.42%Couleur et forme :SolidMasse moléculaire :272.25Ref: TM-TJS1779
1mg87,00€5mg216,00€10mg354,00€25mg582,00€50mg825,00€100mg1.111,00€1mL*10mM (DMSO)197,00€UC-514321
CAS :UC-514321 directly targets STAT3/5 and represses TET1 expression.Formule :C26H35NO5Degré de pureté :97%Couleur et forme :SolidMasse moléculaire :441.56Ref: TM-T13950
1mg78,00€5mg169,00€10mg264,00€25mg528,00€50mg810,00€100mg1.169,00€200mg1.568,00€1mL*10mM (DMSO)178,00€Morusin
CAS :Morusin shows anti-tumor, antioxidant, and anti-inflammatory properties by inhibiting STAT3, NFκB, and inducing apoptosis.Formule :C25H24O6Degré de pureté :98.68% - 99.8%Couleur et forme :SolidMasse moléculaire :420.45Antitumor agent-73
CAS :Antitumor Agent-73, derived from Diosgenin, blocks STAT3 and activates Pdia3, showing strong cancer cell line efficacy.Formule :C50H82BrO4PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :858.06Picroside I
CAS :Picroside I (6'-Cinnamoylcatalpol), a hepatoprotective agent, is reported to be antimicrobial and used against hepatitis B.Formule :C24H28O11Degré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :492.47SC-43
CAS :SC-43 is a potent and orally active agonist of SHP-1 (PTPN6).Formule :C21H13ClF3N3O2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :431.8S3I-201
CAS :S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.Formule :C16H15NO7SDegré de pureté :97.83%Couleur et forme :SolidMasse moléculaire :365.36BD750
CAS :BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM inFormule :C14H13N3OSDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :271.34Stattic
CAS :Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation.Formule :C8H5NO4SDegré de pureté :98.54% - 99.76%Couleur et forme :SolidMasse moléculaire :211.19Ref: TM-T6308
5mg35,00€10mg51,00€25mg85,00€50mg124,00€100mg187,00€200mg279,00€500mg465,00€1mL*10mM (DMSO)55,00€WP1066
CAS :WP1066 is a inhibitor of JAK2 (IC50: 2.30 μM) and STAT3 (IC50: 2.43 μM) in HEL cells; shows activity to JAK2, STAT3/5, and ERK1/2, not JAK1 and JAK3.Formule :C17H14BrN3ODegré de pureté :98.92% - 99.73%Couleur et forme :SolidMasse moléculaire :356.22SC99
CAS :SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Ref: TM-T8719
1mg46,00€5mg93,00€10mg140,00€25mg240,00€50mg363,00€100mg452,00€200mg630,00€1mL*10mM (DMSO)99,00€AS1517499
CAS :AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nMFormule :C20H20ClN5O2Degré de pureté :98.27% - 98.7%Couleur et forme :SolidMasse moléculaire :397.86Ref: TM-T4476
1mg40,00€2mg52,00€5mg88,00€10mg119,00€25mg235,00€50mg376,00€100mg469,00€500mg1.064,00€1mL*10mM (DMSO)87,00€
