JNK
Les JNK (c-Jun N-terminal kinases) sont un sous-groupe de la famille MAPK qui répondent aux stimuli de stress, tels que les cytokines, les radiations ultraviolettes et les chocs thermiques, et sont impliqués dans le contrôle de l'apoptose, de l'inflammation et des réponses immunitaires. La signalisation JNK est cruciale pour la régulation des réponses cellulaires au stress et a été impliquée dans diverses maladies, y compris les troubles neurodégénératifs, le cancer et les affections inflammatoires. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie JNK pour soutenir vos recherches sur la signalisation du stress, l'apoptose et la pathologie des maladies.
Produits appartenant à la catégorie "JNK"
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JNK-1-IN-3
JNK-1-IN-3 (Compound 9e) acts as a JNK1 inhibitor, both reducing JNK1 gene expression and lowering the protein levels of its phosphorylated form. It concurrently diminishes the expression of downstream targets c-Jun and c-Fos in tumors, while also restoring p53 activity. Exhibiting broad-spectrum antiproliferative effects, JNK-1-IN-3 is particularly effective against renal and breast cancer cell lines, showing significant anticancer activity both in vivo and in vitro.Formule :C19H17FN4O3Couleur et forme :SolidMasse moléculaire :368.36JNK1 Protein, Human, Recombinant (GST)
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family.Couleur et forme :Lyophilized PowderMasse moléculaire :75 kDa (predicted); 65 kDa (reducing conditions)JNK3 inhibitor-3
CAS :JNK3 Inhibitor-3 selectively blocks JNK3 (>4.1 nM), crosses the blood-brain barrier, is orally active, and improves memory in dementia mice.Formule :C26H25N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :467.52WHI-P258
CAS :WHI-P258, a weak JAK3 inhibitor, is used as a negative control in drug development.Formule :C16H15N3O2Degré de pureté :99.64% - 99.95%Couleur et forme :SolidMasse moléculaire :281.31Chloramphenicol
CAS :Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.Formule :C11H12Cl2N2O5Degré de pureté :99.6% - 99.84%Couleur et forme :Needles Or Elongated Plates From Water Or Ethylene Dichloride SolidMasse moléculaire :323.13JNK-IN-11
CAS :JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formule :C12H11NO3S2Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :281.35Fasudil
CAS :Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Formule :C14H17N3O2SDegré de pureté :99.79% - 99.84%Couleur et forme :SolidMasse moléculaire :291.37Epieriocalyxin A
CAS :Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Formule :C20H24O5Degré de pureté :97.00%Couleur et forme :SolidMasse moléculaire :344.4JNK-IN-13
CAS :JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Formule :C13H7ClN4SDegré de pureté :98.74%Couleur et forme :SolidMasse moléculaire :286.74SR-3306
CAS :SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.Formule :C28H26N8ODegré de pureté :99.50% - 99.81%Couleur et forme :SolidMasse moléculaire :490.56Ref: TM-T16927
1mg52,00€5mg103,00€10mg160,00€25mg304,00€50mg550,00€100mg882,00€500mg1.768,00€1mL*10mM (DMSO)114,00€Juglanin
CAS :Juglanin is a JNK activator. Juglanin with inflammation and anti-tumor activities. It can induce apoptosis and autophagy on human breast cancer cells.Formule :C20H18O10Degré de pureté :98.8% - 99.33%Couleur et forme :SolidMasse moléculaire :418.35NBDHEX
CAS :NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).Formule :C12H15N3O4SDegré de pureté :97.38%Couleur et forme :SolidMasse moléculaire :297.33BI-78D3
CAS :BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.Formule :C13H9N5O5S2Degré de pureté :100% - 97.89%Couleur et forme :SolidMasse moléculaire :379.37SP600125
CAS :SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitiveFormule :C14H8N2ODegré de pureté :97.63% - 99.58%Couleur et forme :SolidMasse moléculaire :220.23JNK-IN-7
CAS :JNK-IN-7 (JNK inhibitor) is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM).Formule :C28H27N7O2Degré de pureté :99.53% - 99.58%Couleur et forme :SolidMasse moléculaire :493.56Ref: TM-T3598
1mg87,00€2mg158,00€5mg226,00€10mg290,00€25mg522,00€50mg752,00€100mg1.026,00€1mL*10mM (DMSO)245,00€Ezatiostat hydrochloride
CAS :Ezatiostat HCl (TLK199) inhibits glutathione S-transferase, GSTP1-1 specifically, and may treat cytopenias.Formule :C27H36ClN3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :566.11Ref: TM-T22776
2mg58,00€5mg82,00€10mg120,00€25mg200,00€50mg306,00€100mg517,00€200mg777,00€500mg1.165,00€1mL*10mM (DMSO)118,00€IQ-1S free acid
CAS :IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity.Formule :C15H9N3ODegré de pureté :97.92% - 99.05%Couleur et forme :SolidMasse moléculaire :247.25Ref: TM-T3627
5mg47,00€10mg52,00€25mg96,00€50mg169,00€100mg304,00€200mg454,00€500mg733,00€1mL*10mM (DMSO)50,00€TC ASK 10
CAS :TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.Formule :C21H23Cl2N5ODegré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :432.35Ref: TM-T13099
1mg34,00€5mg90,00€10mg131,00€25mg250,00€50mg393,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)90,00€CC-90001
CAS :CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.Formule :C16H27N5O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :321.42Ref: TM-T9688
1mg157,00€5mg323,00€10mg510,00€25mg825,00€50mg1.130,00€100mg1.510,00€1mL*10mM (DMSO)354,00€TCS JNK 5a
CAS :TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).Formule :C20H16N2OSDegré de pureté :97.88% - 99.5%Couleur et forme :SolidMasse moléculaire :332.42
