JNK
Les JNK (c-Jun N-terminal kinases) sont un sous-groupe de la famille MAPK qui répondent aux stimuli de stress, tels que les cytokines, les radiations ultraviolettes et les chocs thermiques, et sont impliqués dans le contrôle de l'apoptose, de l'inflammation et des réponses immunitaires. La signalisation JNK est cruciale pour la régulation des réponses cellulaires au stress et a été impliquée dans diverses maladies, y compris les troubles neurodégénératifs, le cancer et les affections inflammatoires. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie JNK pour soutenir vos recherches sur la signalisation du stress, l'apoptose et la pathologie des maladies.
Produits appartenant à la catégorie "JNK"
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n-Butyl α-D-fructofuranoside
CAS :N-Butyl α-D-fructofuranoside, extracted from the root barks of Ulmus davidiana var.Formule :C10H20O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :236.26Astragaloside IV
CAS :Astragaloside IV suppresses ERK1/2, JNK, MMP-2/9 in breast cancer; inhibits adenovirus and protects cardiovascular, immune, digestive, nervous systems.Formule :C41H68O14Degré de pureté :99% - 99.84%Couleur et forme :Hydroscopic Brown Or Yellow PowderMasse moléculaire :784.97IMM-H007
CAS :IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormule :C22H23N5O8Degré de pureté :97.73%Couleur et forme :SolidMasse moléculaire :485.45Ref: TM-T9010
1mg40,00€5mg96,00€10mg135,00€25mg226,00€50mg320,00€100mg434,00€200mg602,00€1mL*10mM (DMSO)131,00€Vacquinol-1
CAS :Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.Formule :C21H21ClN2ODegré de pureté :98.67%Couleur et forme :SolidMasse moléculaire :352.86Ezatiostat
CAS :Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.Formule :C27H35N3O6SDegré de pureté :97.95%Couleur et forme :SolidMasse moléculaire :529.65Urolithin B
CAS :Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pomegranates, berries, walnuts, tropicalFormule :C13H8O3Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :212.2IQ-3
CAS :IQ3 inhibits JNK3 (Kd 66 nM), JNK1/2, NF-κB/AP1 in THP1-Blue cells (IC50 1.4 μM), and reduces TNF-α/IL-6 production.Formule :C20H11N3O3Degré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :341.32Guggulsterone
CAS :Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.Formule :C21H28O2Degré de pureté :99.40% - 99.8%Couleur et forme :Light Yellow PowderMasse moléculaire :312.45Ref: TM-T5574
1mg35,00€5mg55,00€10mg93,00€25mg178,00€50mg245,00€100mg360,00€200mg532,00€1mL*10mM (DMSO)60,00€Taurochenodeoxycholic Acid
CAS :Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.Formule :C26H45NO6SDegré de pureté :99.69% - 99.86%Couleur et forme :SolidMasse moléculaire :499.7JNK-IN-8
CAS :JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Formule :C29H29N7O2Degré de pureté :100% - 99.59%Couleur et forme :SolidMasse moléculaire :507.59Ref: TM-T2668
2mg47,00€5mg77,00€10mg119,00€25mg207,00€50mg344,00€100mg510,00€200mg722,00€1mL*10mM (DMSO)87,00€p38 Kinase inhibitor 8
CAS :p38 Kinase inhibitor 8 (Compound CCLXXVIII) is an orally active inhibitor targeting p38β and JNK2α2, with IC50 values of 6.3 nM and 53.6 nM, respectively. It has demonstrated anti-inflammatory effects in a rat model of collagen-induced arthritis.Formule :C22H21FN6O2Couleur et forme :SolidMasse moléculaire :420.44Mefloquine
CAS :Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.Formule :C17H16F6N2ODegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :378.31Ref: TM-T0860L
1mg70,00€5mg154,00€10mg225,00€25mg376,00€50mg538,00€100mg755,00€200mg1.017,00€1mL*10mM (DMSO)160,00€(±)-Perillaldehyde
CAS :(±)-Perillaldehyde exhibits antidepressant effects in mice with stress-induced depressive-like behavior by modulating the olfactory nervous system. Additionally, it demonstrates anti-inflammatory activity by activating JNK in RAW264.7 cells and suppressing the expression of TNF-α, with an IC50 value of 171.7 μM.Formule :C10H14OCouleur et forme :SolidMasse moléculaire :150.22PROTAC JNK1-targeted-1
PROTAC JNK1-targeted-1 (PA2) is a JNK1 PROTAC degrader with a DC50 of 10 nM. It effectively reduces fibronectin levels and is useful in lung fibrosis research. [Pink: JNK1 inhibitor; Black: linker; Blue: CRBN Ligand]Formule :C35H32BrN9O6Masse moléculaire :754.589Anisomycin
CAS :Anisomycin (NSC-76712), an antibiotic from Streptomyces, blocks protein/DNA synthesis by targeting peptidyl transferase/80S ribosomes.Formule :C14H19NO4Degré de pureté :98.33% - 99.81%Couleur et forme :White Crystalline SolidMasse moléculaire :265.3Tanzisertib
CAS :Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Formule :C21H23F3N6O2Degré de pureté :98.66% - 99.28%Couleur et forme :SolidMasse moléculaire :448.44Ref: TM-T14895
1mg42,00€5mg87,00€10mg145,00€25mg283,00€50mg558,00€100mg743,00€200mg1.026,00€1mL*10mM (DMSO)96,00€JNK-1-IN-2
"JNK-1-IN-2 (Compound c6) is a potent inhibitor of JNK-1 with an IC50 of 33.5 nM, and also exhibits inhibitory effects on JNK-2 and JNK-3 with IC50 values ofFormule :C16H20BrN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :378.27Bentamapimod
CAS :Bentamapimod (AS 602801) is a novel, orally active inhibitor of JNK.Formule :C25H23N5O2SDegré de pureté :95.21% - 99.92%Couleur et forme :SolidMasse moléculaire :457.55Ref: TM-T2675
1g2.080,00€2g2.802,00€2mg46,00€5mg66,00€10mg99,00€25mg162,00€50mg197,00€100mg350,00€500mg1.149,00€Isovitexin
CAS :1.Formule :C21H20O10Degré de pureté :98.24% - 99.79%Couleur et forme :SolidMasse moléculaire :432.38Ref: TM-T6S1371
1mg52,00€5mg97,00€10mg140,00€25mg274,00€50mg411,00€100mg597,00€500mg1.225,00€1mL*10mM (DMSO)105,00€AS601245
CAS :AS601245 is an inhibitor of the c-Jun NH2-terminal kinase (JNK), with neuroprotective properties.Formule :C20H16N6SDegré de pureté :98% - 99.02%Couleur et forme :SolidMasse moléculaire :372.45
