MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
Produits appartenant à la catégorie "MAPK"
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CHPG hydrochloride
CHPG hydrochloride is a selective agonist of mGluR5.Formule :C8H9Cl2NO3Degré de pureté :98.1%Couleur et forme :SoildMasse moléculaire :238.07Ref: TM-T10809L
1mg56,00€5mg116,00€10mg168,00€25mg269,00€50mg383,00€100mg510,00€200mg692,00€1mL*10mM (DMSO)101,00€SB 202190 hydrochloride
CAS :SB 202190 hydrochloride is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor ,differentiation to cardiomyocytes.Formule :C20H15ClFN3ODegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :367.8Ref: TM-T35592
2mg49,00€5mg66,00€10mg90,00€25mg145,00€50mg207,00€100mg309,00€200mg459,00€1mL*10mM (DMSO)71,00€Raf inhibitor 3
CAS :Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formule :C18H19FN8O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :430.46Lupalbigenin
CAS :Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.Formule :C25H26O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.47Xl-281
CAS :XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Formule :C24H19ClN4O4Degré de pureté :95.77% - 98.60%Couleur et forme :SolidMasse moléculaire :462.89ERK5-IN-5
CAS :ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formule :C19H16ClN3ODegré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :337.8Ref: TM-T77734
1mg86,00€2mg111,00€5mg180,00€10mg279,00€25mg562,00€50mg917,00€100mg1.454,00€500mg2.822,00€Farrerol
CAS :Farrerol shows antioxidative effects, modulates genes, fights S. aureus in cows, protects cells, and may prevent heart disease.Formule :C17H16O5Degré de pureté :99.89% - 99.96%Couleur et forme :SolidMasse moléculaire :300.31Ref: TM-T6S0525
2mg43,00€5mg59,00€10mg85,00€25mg120,00€50mg170,00€100mg253,00€200mg375,00€1mL*10mM (DMSO)71,00€B-Raf IN 16
CAS :B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formule :C20H19N5O3SDegré de pureté :98.59% - 99.56%Couleur et forme :SolidMasse moléculaire :409.46Gardenin A
CAS :Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.Formule :C21H22O9Degré de pureté :95.15% - 95.15%Couleur et forme :SolidMasse moléculaire :418.39Ref: TM-TN4114
1mg187,00€5mg467,00€10mg693,00€25mg1.074,00€50mg1.454,00€100mg1.882,00€500mg3.924,00€1mL*10mM (DMSO)502,00€1-(4-methansulfinylphenyl)ethanone
CAS :The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Formule :C9H10O2SDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :182.24Ref: TM-T8870
1mg51,00€5mg153,00€10mg207,00€25mg288,00€50mg404,00€100mg562,00€200mg758,00€1mL*10mM (DMSO)101,00€p38-α MAPK-IN-10
CAS :p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.Formule :C27H34Cl2N6Couleur et forme :SolidMasse moléculaire :513.505Corylifol C
CAS :Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factorFormule :C20H18O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :338.35SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Formule :C29H34F3N5O2Couleur et forme :SolidMasse moléculaire :541.61JWG-071
CAS :JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.Formule :C34H44N8O3Degré de pureté :98.33%Couleur et forme :SolidMasse moléculaire :612.77Rasarfin
CAS :Rasarfin inhibits Ras and ARF6.Formule :C23H24ClN3O3Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :425.91Ref: TM-T9407
1mg40,00€5mg80,00€10mg116,00€25mg205,00€50mg340,00€100mg485,00€200mg655,00€1mL*10mM (DMSO)88,00€DB07268
CAS :DB07268 is a potent and selective JNK1 inhibitor.Formule :C17H15N5O2Degré de pureté :98.2% - 98.91%Couleur et forme :SolidMasse moléculaire :321.33Laxiflorin B-4
Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].Degré de pureté :98%Couleur et forme :Odour SolidPS-166276
CAS :PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.Formule :C20H30N8OCouleur et forme :SolidMasse moléculaire :398.51NCB-0846
CAS :NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Formule :C21H21N5O2Degré de pureté :97.04% - 99.46%Couleur et forme :SolidMasse moléculaire :375.42LJI308
CAS :LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.Formule :C21H18F2N2O2Degré de pureté :98.86% - 99.73%Couleur et forme :SolidMasse moléculaire :368.38
