MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
Produits appartenant à la catégorie "MAPK"
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AS601245.2TFA (345987-15-7 free base)
CAS :AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formule :C24H18F6N6O4SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :600.50AMG-548 hydrochloride (864249-60-5 free base)
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selectiveFormule :C29H28ClN5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.02J30-8
CAS :J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formule :C17H9ClFN3O2SDegré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :373.794-(3,4-Dimethoxyphenyl)-3-buten-1-ol
CAS :'E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol could boost melanin synthesis through USF1 to treat hypopigmentation.'Formule :C12H16O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :208.25LY-364947
CAS :LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.Formule :C17H12N4Degré de pureté :99.41% - 99.96%Couleur et forme :SolidMasse moléculaire :272.3Ref: TM-T2048
5mg65,00€10mg82,00€25mg143,00€50mg255,00€100mg374,00€200mg560,00€500mg877,00€1mL*10mM (DMSO)72,00€M443
CAS :M443 is a potent small molecule inhibitor of MRK that inhibits radiation-induced activation of p38 and Chk2 and can be used in cancer research.Formule :C31H30F3N7O2Degré de pureté :98.95%Couleur et forme :SolidMasse moléculaire :589.61LY-2584702 tosylate salt
CAS :LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.Formule :C28H27F4N7O3SDegré de pureté :98.5% - 98.51%Couleur et forme :SolidMasse moléculaire :617.62Ref: TM-T1746
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg216,00€50mg359,00€100mg512,00€500mg1.093,00€1mL*10mM (DMSO)96,00€B-Raf IN 15
CAS :B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used to study melanoma and cancer.Formule :C19H15N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :333.41BSc5367
CAS :BSc5367 is a potent inhibitor of the structural domain of Nek1 kinase.cell cycle regulation, DNA repair, and microtubule regulation. ALS, PKD.Formule :C20H15N3O2Degré de pureté :98.72%Masse moléculaire :329.35Ref: TM-T201389
1mg97,00€5mg170,00€10mg269,00€25mg565,00€50mg877,00€100mg1.366,00€1mL*10mM (DMSO)185,00€methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
CAS :methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.Formule :C13H13NO5Degré de pureté :97.69%Couleur et forme :SolidMasse moléculaire :263.25LM22B-10
CAS :LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.Formule :C27H33ClN2O4Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :485.01NHTD
CAS :NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47MHJ-627
MHJ-627, a potent inhibitor of ERK5 (MAPK7) with an IC50 value of 0.91 μM, enhances the mRNA expression of tumor suppressors and anti-metastatic genes, leadingFormule :C34H45BrN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :609.64Anti-ERK2 Antibody (4F551)
Anti-ERK2 Antibody (4F551) is a Rabbit antibody targeting ERK2. Anti-ERK2 Antibody (4F551) can be used in ELISA,FCM.Couleur et forme :Odour LiquidPLX-4720
CAS :PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formule :C17H14ClF2N3O3SDegré de pureté :97.78% - 99.83%Couleur et forme :SolidMasse moléculaire :413.83PH-797804
CAS :PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Formule :C22H19BrF2N2O3Degré de pureté :97.79% - 97.90%Couleur et forme :SolidMasse moléculaire :477.3Ref: TM-T1974
1mg46,00€5mg94,00€10mg144,00€25mg255,00€50mg406,00€100mg628,00€500mg1.320,00€1mL*10mM (DMSO)97,00€MK-8353
CAS :MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)Formule :C37H41N9O3SDegré de pureté :96.15% - 99.89%Couleur et forme :SolidMasse moléculaire :691.84Ref: TM-T12069
1mg81,00€5mg156,00€10mg271,00€25mg620,00€50mg938,00€100mg1.454,00€1mL*10mM (DMSO)230,00€CAY10404
CAS :CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.Formule :C17H12F3NO3SDegré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :367.34Ref: TM-T8656
2mg35,00€5mg52,00€10mg96,00€25mg177,00€50mg304,00€100mg437,00€200mg615,00€1mL*10mM (DMSO)58,00€BSJ-04-122
CAS :BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formule :C15H12ClN5ODegré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :313.74SGX-523
CAS :SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.Formule :C18H13N7SDegré de pureté :100% - 99.49%Couleur et forme :SolidMasse moléculaire :359.41
