MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
Produits appartenant à la catégorie "MAPK"
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JNK-IN-14
JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.Formule :C27H31N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.63BI-2493
CAS :BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth.Cost-effective and quality-assured.Formule :C24H27N7OSDegré de pureté :97.03% - 99.51%Couleur et forme :SoildMasse moléculaire :461.58Jolkinolide B
CAS :Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud.Formule :C20H26O4Degré de pureté :99.39% - 99.7%Couleur et forme :SolidMasse moléculaire :330.42Effusanin A
CAS :Effusanin A: antibacterial, damages DNA, inhibits DU145 cells at 3.16 μM and LoVo cells at 3.02 μM.Formule :C20H28O5Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :348.43Regorafenib Hydrochloride
CAS :Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Formule :C21H16Cl2F4N4O3Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :519.28pan-KRAS degrader 1
CAS :Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.Formule :C22H26N8OSCouleur et forme :SolidMasse moléculaire :450.56Deltonin
CAS :Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).Formule :C45H72O17Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :885.04Galangin
CAS :Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.Formule :C15H10O5Degré de pureté :98.24% - 99.93%Couleur et forme :Yellowish Needle-Like CrystalMasse moléculaire :270.24ERK5-IN-2
CAS :ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.Formule :C17H11BrFN3O2Degré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :388.19Ref: TM-T5535
1mg48,00€5mg96,00€10mg169,00€25mg283,00€50mg424,00€100mg612,00€200mg842,00€1mL*10mM (DMSO)111,00€CC-401 Hydrochloride
CAS :CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formule :C22H25ClN6ODegré de pureté :99.53% - ≥95%Couleur et forme :SolidMasse moléculaire :424.93Anti-ERK2 Antibody (9C922)
Anti-ERK2 Antibody (9C922) is a Mouse antibody targeting ERK2. Anti-ERK2 Antibody (9C922) can be used in WB,ELISA.Couleur et forme :Odour LiquidSB220025
CAS :SB220025 is a P38 mitogen-activated protein kinase inhibitor that inhibits p56Lck and PKC, and inhibits angiogenesis.Formule :C18H19FN6Degré de pureté :99.44%Couleur et forme :SolidMasse moléculaire :338.38JNK-1-IN-3
JNK-1-IN-3 (Compound 9e) acts as a JNK1 inhibitor, both reducing JNK1 gene expression and lowering the protein levels of its phosphorylated form. It concurrently diminishes the expression of downstream targets c-Jun and c-Fos in tumors, while also restoring p53 activity. Exhibiting broad-spectrum antiproliferative effects, JNK-1-IN-3 is particularly effective against renal and breast cancer cell lines, showing significant anticancer activity both in vivo and in vitro.Formule :C19H17FN4O3Couleur et forme :SolidMasse moléculaire :368.362,5-Dihydroxyacetophenone
CAS :2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formule :C8H8O3Degré de pureté :99.75%Couleur et forme :Yellow PowderMasse moléculaire :152.15Losmapimod
CAS :Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).Formule :C22H26FN3O2Degré de pureté :98.56% - 99.05%Couleur et forme :SolidMasse moléculaire :383.46Ref: TM-T2277
2mg35,00€5mg52,00€10mg78,00€25mg139,00€50mg225,00€100mg406,00€500mg920,00€1mL*10mM (DMSO)55,00€Doramapimod
CAS :Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Formule :C31H37N5O3Degré de pureté :97.73% - 98.80%Couleur et forme :SolidMasse moléculaire :527.66Ref: TM-T6277
1g562,00€5mg37,00€10mg55,00€25mg79,00€50mg92,00€100mg127,00€200mg225,00€500mg379,00€1mL*10mM (DMSO)44,00€BIX02189
CAS :BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.Formule :C27H28N4O2Degré de pureté :98% - 99.86%Couleur et forme :SolidMasse moléculaire :440.54Ref: TM-T2416
1mg40,00€2mg52,00€5mg87,00€10mg123,00€25mg221,00€50mg378,00€100mg648,00€200mg904,00€500mg1.320,00€1mL*10mM (DMSO)96,00€Manassantin A
CAS :Manassantin A: potent HIF-1 inhibitor, guards stomach lining, curbs iNOS/NF-κB, may help treat airway diseases, reduces melanin by affecting MITF/tyrosinase.Formule :C42H52O11Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :732.867SOS1-IN-15
CAS :SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.Formule :C28H27F3N6O2Degré de pureté :98.32%Couleur et forme :SolidMasse moléculaire :536.548Vem-L-Cy5
Vem-L-Cy5 (compound 3), a Vemurafenib-based BRAF inhibitor conjugated with the near-infrared (NIR) fluorophore cyanine-5 (Cy5), selectively targets the BRAFFormule :C63H68F5N7O9SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1194.31
