MAPK
Les MAPK sont une famille de kinases protéiques impliquées dans une variété de processus cellulaires, y compris la croissance, la prolifération, la différenciation et les réponses au stress. La voie de signalisation MAPK comprend plusieurs niveaux, y compris ERK, JNK et p38 MAPK, chacun jouant des rôles distincts dans la fonction cellulaire. La dérégulation de la signalisation MAPK est liée au cancer, aux maladies inflammatoires et aux troubles métaboliques. Chez CymitQuimica, nous offrons un large éventail d'inhibiteurs et d'activateurs de MAPK pour soutenir vos recherches en biologie cellulaire, transduction de signaux et mécanismes des maladies.
Produits appartenant à la catégorie "MAPK"
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6-Acetonyldihydrochelerythrine
CAS :6-Acetonyldihydrochelerythrine: anti-HIV, antioxidant, induces apoptosis, cytotoxic to HCT116/SW620 cells, more effective than 5-FU. EC50=1.77µg/mL, TI=14.6.Formule :C24H23NO5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.44Bohemine
CAS :Bohemine is a cyclin-dependent kinase inhibitor.Formule :C18H24N6ODegré de pureté :99.09% - 99.53%Couleur et forme :SolidMasse moléculaire :340.42Antimicrobial agent-21
CAS :Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormule :C18H13N3OSDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :319.38Ref: TM-T67942
1mg81,00€5mg170,00€10mg259,00€25mg419,00€50mg562,00€100mg770,00€200mg1.035,00€1mL*10mM (DMSO)271,00€GSK2008607
CAS :GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.Formule :C31H28F3N7O3S2Degré de pureté :99%Couleur et forme :SolidMasse moléculaire :667.72Ref: TM-T27454
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€Lambertellin
CAS :Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.Formule :C14H8O5Couleur et forme :SolidMasse moléculaire :256.216,4'-Dihydroxy-7-methoxyflavanone
CAS :Active compound from Dalbergia odorifera with antioxidant, anti-inflammatory, neuroprotective properties, may treat bone diseases.Formule :C16H14O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :286.28KRAS inhibitor-8
CAS :KRAS inhibitor-8 is a potent KRAS G12C inhibitor.Formule :C26H24ClF4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.95A-674563
CAS :A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.Formule :C22H22N4ODegré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :358.44KRAS G12C inhibitor 5
CAS :KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Formule :C32H37N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :551.68PD184161
CAS :PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Formule :C17H13BrClF2IN2O2Degré de pureté :99.40%Couleur et forme :SolidMasse moléculaire :557.56Ref: TM-T21635
1mg38,00€2mg52,00€5mg79,00€10mg126,00€25mg273,00€50mg454,00€100mg653,00€200mg938,00€500mg1.406,00€KB-5246
CAS :KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Formule :C18H17ClFN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.86Belvarafenib
CAS :Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.Formule :C23H16ClFN6OSDegré de pureté :99.44% - ≥98%Couleur et forme :SolidMasse moléculaire :478.93SJ-C1044
CAS :SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF(V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.Formule :C25H14F7N7OCouleur et forme :SolidMasse moléculaire :561.41ERK-IN-3
CAS :ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Formule :C22H25ClFN7O2Degré de pureté :99.55% - 99.76%Couleur et forme :SolidMasse moléculaire :473.93JNK-IN-11
CAS :JNK-IN-11 inhibits JNK1/2/3 (IC50: 2.2/21.4/1.8 μM); promising for Alzheimer's/Parkinson's research.Formule :C12H11NO3S2Degré de pureté :98.82%Couleur et forme :SolidMasse moléculaire :281.35AZD8330
CAS :AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formule :C16H17FIN3O4Degré de pureté :98.72%Couleur et forme :SolidMasse moléculaire :461.23p38 Kinase inhibitor 7
CAS :p38 Kinase inhibitor 7 (Comp:XXXIX) is an inhibitor of p38α, with an IC50 value of 5.25 nM. It also effectively suppresses TNFα production in THP-1 cells, demonstrating an IC50 of 5.88 nM.Formule :C22H25FN6OCouleur et forme :SolidMasse moléculaire :408.472B-Raf IN 2
CAS :B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Formule :C20H17F2N5O4SDegré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :461.44Nisin Z
CAS :Nisin Z has anti-inflammatory activity and reduces the release of pro-inflammatory cytokines.Formule :C141H229N41O38S7Couleur et forme :SolidMasse moléculaire :3331.03Plx-4032
CAS :Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Formule :C23H18ClF2N3O3SDegré de pureté :98.53% - 99.36%Couleur et forme :SolidMasse moléculaire :489.92
