Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
Produits appartenant à la catégorie "Ras"
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ARS-1323
CAS :ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.Formule :C21H17ClF2N4O2Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :430.84FTI-277 hydrochloride
CAS :FTI-277 HCl: potent FTase inhibitor, IC50 500 pM, 100x more selective than GGTase I.Formule :C22H30ClN3O3S2Degré de pureté :97.57% - 97.61%Couleur et forme :SolidMasse moléculaire :484.07Ref: TM-T2700
1mg52,00€2mg73,00€5mg96,00€10mg175,00€25mg320,00€50mg537,00€100mg753,00€1mL*10mM (DMSO)111,00€Kobe2602
CAS :Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Formule :C14H9F4N5O4SDegré de pureté :98.36% - 99.39%Couleur et forme :SolidMasse moléculaire :419.31GGTI298 Trifluoroacetate
CAS :GGTI298 trifluoroacetate (GGTI298TFA salt) is a geranylgeranyltransferase I inhibitor that causes cell cycle arrest and induces apoptosis.Formule :C27H33N3O3S·C2HF3O2Degré de pureté :100% - 98.29%Couleur et forme :SolidMasse moléculaire :593.66ARS-1630
CAS :ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formule :C21H17ClF2N4O2Degré de pureté :97.81%Couleur et forme :SolidMasse moléculaire :430.84Ref: TM-T10376
1mg52,00€5mg117,00€10mg170,00€25mg325,00€50mg469,00€100mg615,00€1mL*10mM (DMSO)134,00€SOS2 ligand 1
CAS :SOS2 ligand 1 (compound 2) is a selective ligand for son of sevenless 2 (SOS2), exhibiting a KD value of 4.6 µM.Formule :C19H21N5OCouleur et forme :SolidMasse moléculaire :335.403ML141
CAS :ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).Formule :C22H21N3O3SDegré de pureté :99.36% - 99.56%Couleur et forme :SolidMasse moléculaire :407.49Ref: TM-T2463
1mg39,00€2mg50,00€5mg72,00€10mg110,00€25mg225,00€50mg406,00€100mg582,00€500mg1.254,00€1mL*10mM (DMSO)74,00€ESI-08
CAS :ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.Formule :C20H23N3OSDegré de pureté :99.05%Couleur et forme :SolidMasse moléculaire :353.48NSC 23766 trihydrochloride
CAS :NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs; no inhibitory for RhoA or Cdc42.Formule :C24H35N7·3HClDegré de pureté :96.48% - 99.54%Couleur et forme :SolidMasse moléculaire :530.96MBQ-167
CAS :MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).Formule :C22H18N4Degré de pureté :98.07% - 98.74%Couleur et forme :SolidMasse moléculaire :338.41Ref: TM-T16021
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg208,00€50mg376,00€100mg567,00€1mL*10mM (DMSO)87,00€SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Formule :C29H34F3N5O2Couleur et forme :SolidMasse moléculaire :541.61Rasarfin
CAS :Rasarfin inhibits Ras and ARF6.Formule :C23H24ClN3O3Degré de pureté :97.98%Couleur et forme :SolidMasse moléculaire :425.91Ref: TM-T9407
1mg40,00€5mg80,00€10mg116,00€25mg205,00€50mg340,00€100mg485,00€200mg655,00€1mL*10mM (DMSO)88,00€CCG-222740
CAS :CCG-222740 is an inhibitor of Rho/MRTF pathwayFormule :C23H19ClF2N2O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :444.86Ref: TM-T7764
2mg42,00€5mg65,00€10mg99,00€25mg182,00€50mg279,00€100mg414,00€200mg587,00€1mL*10mM (DMSO)70,00€6H05
CAS :6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).Formule :C20H30ClN3O2S3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :476.12KRAS inhibitor-32
CAS :KRAS inhibitor-32 (compound 139A) is a KRAS inhibitor utilized in cancer research.Formule :C29H35FN10OS2Couleur et forme :SolidMasse moléculaire :622.78Adagrasib
CAS :View and buy Adagrasib (MRTX849) from TargetMol.MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. Cited in 2 publications.Formule :C32H35ClFN7O2Degré de pureté :99.10% - 99.9%Couleur et forme :SolidMasse moléculaire :604.12LUNA18
CAS :LUNA18 is an orally active inhibitor targeting KRAS, exhibiting potent activity with an IC50 value of less than 2 nM against the KRAS G12D-SOS mutation.Formule :C73H105F5N12O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1437.68KRas G12C inhibitor 4
CAS :KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.Formule :C33H38ClN7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :600.15NHTD
CAS :NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formule :C24H26N2O5Couleur et forme :SolidMasse moléculaire :422.47Atranorin
CAS :Atranorin has antinociceptive, anti-inflammatory, can be pro-oxidant or antioxidant, and protects cells from H(2)O(2)-induced oxidative stress.Formule :C19H18O8Degré de pureté :98% - 99.57%Couleur et forme :SolidMasse moléculaire :374.34
