Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
Produits appartenant à la catégorie "Ras"
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KRAS G12C inhibitor 32
CAS :KRAS G12C Inhibitor 32, an eight-membered heterocyclic compound with nitrogen, acts as a potent inhibitor of KRAS G12C [1].Formule :C29H30Cl3FN6O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :635.94Pan-RAS-IN-1
CAS :Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.Formule :C36H41Cl2F3N6O2Degré de pureté :98.57%Couleur et forme :SolidMasse moléculaire :717.65Ref: TM-T16432
1mg80,00€2mg97,00€5mg144,00€10mg216,00€25mg439,00€50mg660,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)221,00€SOS1-IN-16
CAS :SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 ofFormule :C30H31F3N4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :552.59KRAS inhibitor-8
CAS :KRAS inhibitor-8 is a potent KRAS G12C inhibitor.Formule :C26H24ClF4N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.95KRAS G12C inhibitor 5
CAS :KRAS G12C inhibitor 5 is a KRas G12C inhibitor.Formule :C32H37N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :551.68KB-5246
CAS :KB-5246, displays antibacterial activities.is a tetracyclic quinolone.Formule :C18H17ClFN3O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :425.86ERK-IN-3
CAS :ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Formule :C22H25ClFN7O2Degré de pureté :99.55% - 99.76%Couleur et forme :SolidMasse moléculaire :473.93KRAS inhibitor-37
CAS :KRAS inhibitor-37 (compound 2) is a potent inhibitor of KRAS, exhibiting low dissociation constants (KD) with various KRAS mutations: wild type (0.004 nM), G12D (0.041 nM), G12C (0.019 nM), and G12V (0.144 nM). This compound effectively inhibits cell proliferation, demonstrating half-maximal inhibitory concentrations (IC50) ranging from <2 nM to 14 nM in H358, SW620, and PANC08.13 cell lines. KRAS inhibitor-37 holds potential for cancer research applications.Formule :C32H33ClFN7O3Couleur et forme :SolidMasse moléculaire :618.10ZT-12-037-01
CAS :Zt-12-037-01 is a ATP competitive STK19 inhibitor(IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).Formule :C21H31N5O2Degré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :385.5PROTAC K-Ras Degrader-3
CAS :PROTAC K-Ras Degrader-3 is a PROTAC degrader targeting K-Ras, exhibiting a DC50 value of ≤ 1 nM against SW620 KRAS G12D and a GI50 value of ≤ 10 nM in inhibiting the growth of SW620 3D cells. It is used in cancer research.Formule :C57H67F2N9O6Couleur et forme :SolidMasse moléculaire :1012.20RGT-018
CAS :RGT-018 is a potent oral SOS1 inhibitor with antitumor properties. It exerts its anticancer activity by inhibiting KRAS activation, thereby hindering cancer cell proliferation.Formule :C27H24F3N7O2Couleur et forme :SolidMasse moléculaire :535.52J-104871
CAS :J-104871 (UNII-6137X5QNJF) is an FTase inhibitor that inhibits tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.Formule :C38H32N2O12Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :708.67KRAS inhibitor-7
CAS :KRAS inhibitor-7 is a potent KRAS G12C inhibitor.Formule :C26H27ClF2N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.98ML-098
CAS :ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).Formule :C19H19NO3Degré de pureté :99.06% - 99.52%Couleur et forme :SolidMasse moléculaire :309.36Ref: TM-T4619
1mg39,00€2mg49,00€5mg70,00€10mg99,00€25mg200,00€50mg283,00€100mg394,00€500mg934,00€1mL*10mM (DMSO)88,00€Glecirasib
CAS :Glecirasib (JAB-21822,KRAS G12C inhibitor 36) is an orally active KRAS G12C inhibitor that selectively binds to and inhibits KRAS G12C-dependent signalingFormule :C31H26ClF4N7O2Degré de pureté :100% - 100%Couleur et forme :SolidMasse moléculaire :640.03pan-KRAS-IN-17
CAS :pan-KRAS-IN-17 (Example 34) is an inhibitor that targets multiple forms of the KRAS protein.Formule :C34H33F3N5O8PCouleur et forme :SolidMasse moléculaire :727.623MRTF-A-IN-1
MRTF-A-IN-1 (compound 14) is an inhibitor of MRTF-A. It effectively suppresses cell proliferation and induces senescence in HCC cells.Formule :C22H21N3Couleur et forme :SolidMasse moléculaire :327.42XRP44X
CAS :XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.Formule :C21H21ClN4ODegré de pureté :97.51%Couleur et forme :SolidMasse moléculaire :380.87SOS1-IN-11
CAS :SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).Formule :C22H24F3N5ODegré de pureté :98.79%Couleur et forme :SolidMasse moléculaire :431.45Ref: TM-T60029
1mg75,00€5mg169,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€1mL*10mM (DMSO)180,00€BI-2852
CAS :BI-2852: nanomolar affinity KRAS switch I/II pocket inhibitor; blocks signaling, halts KRAS mutant cell growth.Formule :C31H28N6O2Degré de pureté :98.98%Couleur et forme :SolidMasse moléculaire :516.59Ref: TM-T10533
1mg116,00€5mg276,00€10mg410,00€25mg680,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)314,00€
