Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
Produits appartenant à la catégorie "Ras"
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Antifungal agent 46
CAS :Compound 2f (Antifungal Agent 46) is a potent antifungal that inhibits Ras signaling by targeting protein farnesyltransferase [1].Formule :C26H28BrF3N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :565.43Phellodendrine chloride
CAS :Phellodendrine chloride combats kidney inflammation by blocking macrophage and T cell activity in glomeruli.Formule :C20H24ClNO4Degré de pureté :98.85% - 99.05%Couleur et forme :SolidMasse moléculaire :377.86AMG410
CAS :AMG410 is a non-covalent, bimodal GDP (OFF) and GTP (ON)-binding pan-KRAS inhibitor , binds on the variegated pocket, in KRAS G12D, G12V, G12C, G13D.Formule :C31H32ClF2N7O5Couleur et forme :SoildMasse moléculaire :656.08AM-001
CAS :AM-001 is a non-competitive inhibitor of Epac1, preventing the activation of its downstream effector Rap1 in cultured cells. This compound is utilized in research related to cardiac diseases.Formule :C24H16FN3OS2Couleur et forme :SolidMasse moléculaire :445.53KRAS G12D inhibitor 25
CAS :KRAS G12D inhibitor 25 (Compound 148) acts as an inhibitor for KRAS G12C and HSP90α, displaying IC50 values of <0.1 μM and 0.1-1 μM respectively. Additionally, it suppresses the proliferation of MIA PaCa-2 and NCI-H358 cell lines, with EC50 values of <0.1 μM and 0.1-1 μM correspondingly. This compound also promotes the degradation of ERBB2, exhibiting a DC50 of 0.1-1 μM.Formule :C56H62ClN11O6Couleur et forme :SolidMasse moléculaire :1020.62ZCL278
CAS :ZCL278 is a selective Cdc42 GTPase inhibitor.Formule :C21H19BrClN5O4S2Degré de pureté :96.29% - 99.72%Couleur et forme :SolidMasse moléculaire :584.89Ref: TM-T1855
5mg50,00€10mg79,00€25mg136,00€50mg221,00€100mg310,00€200mg497,00€500mg805,00€1mL*10mM (DMSO)79,00€KRAS inhibitor-34
CAS :KRAS inhibitor-34 (compound 27) is a KRAS inhibitor with an IC50 of 6.4 nM and is utilized in oncological research.Formule :C43H41F3N6O3Couleur et forme :SolidMasse moléculaire :746.82ARS-1620
CAS :ARS-1620 is a covalent inhibitor of K-RASG12C.Formule :C21H17ClF2N4O2Degré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :430.84Ref: TM-T7609
1mg92,00€2mg117,00€5mg188,00€10mg274,00€25mg543,00€50mg780,00€100mg938,00€1mL*10mM (DMSO)212,00€K-Ras(G12C) inhibitor 12
CAS :K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formule :C15H17ClIN3O3Degré de pureté :97.16%Couleur et forme :SolidMasse moléculaire :449.67MRTX-1257
CAS :MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formule :C33H39N7O2Degré de pureté :96.59% - 99.07%Couleur et forme :SolidMasse moléculaire :565.71Ref: TM-T16143
1mg64,00€2mg89,00€5mg131,00€10mg220,00€25mg371,00€50mg557,00€100mg797,00€1mL*10mM (DMSO)170,00€Kobe0065
CAS :Kobe0065: novel small-molecule, inhibits Ras-Raf, Ki=46±13 μM, blocks H-Ras·GTP/c-Raf-1 RBD binding.Formule :C15H11ClF3N5O4SDegré de pureté :100% - 99.58%Couleur et forme :SolidMasse moléculaire :449.79BAY-293
CAS :BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formule :C25H28N4O2SDegré de pureté :96.8%Couleur et forme :SolidMasse moléculaire :448.586H05 (TFA)
CAS :6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.Formule :C22H31ClF3N3O4S3Degré de pureté :≥95%Couleur et forme :SolidMasse moléculaire :590.14Ref: TM-T7326
1mg69,00€2mg95,00€5mg134,00€10mg230,00€25mg378,00€50mg568,00€100mg807,00€1mL*10mM (DMSO)170,00€TH-Z835
CAS :TH-Z835 is a selective inhibitor for the KRAS (G12D) mutation, demonstrating an inhibitory concentration (IC50) of 1.6 μM.Formule :C30H38N6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.66RMC-6236
CAS :RMC-6236 is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Formule :C44H58N8O5SDegré de pureté :98.24% - 99.92%Couleur et forme :SolidMasse moléculaire :811.05K-Ras(G12C) Inhibitor 6
CAS :Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.33Ref: TM-T3725
1mg63,00€2mg88,00€5mg133,00€10mg230,00€25mg477,00€50mg667,00€100mg932,00€1mL*10mM (DMSO)133,00€BI1701963
BI1701963 is an orally effective inhibitor that targets the SOS1 and KRAS interaction, specifically inhibiting the activation of KRAS by blocking its GTP loading. This compound is utilized in cancer research to explore potential therapeutic effects against KRAS-driven malignancies.Formule :C47H62N8O4SCouleur et forme :SolidMasse moléculaire :835.11MLS000532223
CAS :MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).Formule :C15H9NO3Degré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :251.24Ref: TM-T8473
1mg130,00€2mg183,00€5mg306,00€10mg462,00€25mg755,00€50mg1.035,00€100mg1.415,00€1mL*10mM (DMSO)319,00€1A-116
CAS :1A-116 is a specific Rac1 inhibitor.Formule :C16H16F3N3Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :307.31Ref: TM-T14004
1mg50,00€5mg111,00€10mg166,00€25mg283,00€50mg444,00€100mg655,00€200mg924,00€1mL*10mM (DMSO)123,00€(S)-AMG-510
CAS :(S)-AMG-510 is the S-type compound of AMG-510 (Sotorasib), which effectively and selectively inhibits KRASG12C.Cost-effective and quality-assured.Formule :C30H30F2N6O3Degré de pureté :98.01% - 99.76%Couleur et forme :SolidMasse moléculaire :560.59Ref: TM-T22258
2mg37,00€5mg52,00€10mg85,00€25mg156,00€50mg274,00€100mg426,00€500mg938,00€1mL*10mM (DMSO)77,00€
