Ras
Les protéines Ras sont de petites GTPases qui agissent comme des commutateurs moléculaires dans la voie de signalisation MAPK, contrôlant la croissance, la différenciation et la survie cellulaires. Ras activé initie une cascade de signalisation qui inclut Raf, MEK et ERK, conduisant à diverses réponses cellulaires. Les mutations des gènes Ras sont courantes dans les cancers, faisant de Ras un point focal important de la recherche sur le cancer. Chez CymitQuimica, nous offrons une gamme de modulateurs de Ras pour soutenir vos recherches en biologie du cancer, transduction de signaux et développement thérapeutique.
Produits appartenant à la catégorie "Ras"
Trier par
K-Ras(G12C) inhibitor 9
CAS :K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78Ref: TM-T6556
1mg52,00€2mg74,00€5mg123,00€10mg183,00€25mg378,00€50mg547,00€100mg750,00€1mL*10mM (DMSO)183,00€KRAS G12C inhibitor 13
CAS :KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .Formule :C40H46F3N7O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :745.83Pan-RAS-IN-7
CAS :Pan-RAS-IN-7 (Compound D101) is a broad-spectrum RAS inhibitor used in the synthesis of antibody-drug conjugates (ADCs). It is also applicable in cancer research.Formule :C59H76N8O8Couleur et forme :SolidMasse moléculaire :1025.28Ketoconazole
CAS :Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.Formule :C26H28Cl2N4O4Degré de pureté :99.53% - 99.62%Couleur et forme :Crystals From 4-Methylpentanone SolidMasse moléculaire :531.43KRAS inhibitor-9
CAS :KRAS inhibitor-9 (DUN09716) hinders GTP-KRAS formation, with a Kd of 92 μM, causes G2/M arrest, and induces apoptosis in mutated NSC-LC cells.Formule :C13H9ClN2S2Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :292.81Ref: TM-T8756
1mg60,00€2mg86,00€5mg119,00€10mg188,00€25mg354,00€50mg512,00€100mg655,00€1mL*10mM (DMSO)143,00€KRAS G12C inhibitor 60
KRAS G12C Inhibitor 60 (compound 23), a selective inhibitor targeting the Kras-G12C mutation, is utilized in the investigation of lung, colorectal, andFormule :C31H30F5N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :627.61KRASG12C IN-14
KRASG12C IN-14 (compound 15), a potent inhibitor specifically designed for the KRAS G12C mutation, exhibits impressive efficacy in impeding CYPA-dependent KRAS-BRAF interaction and ERK phosphorylation in NCI-H358 cells, both with an IC 50 of 0.002 μM.Formule :C51H65F4N9O9S2Couleur et forme :SolidMasse moléculaire :1088.24SOS1/KRAS-IN-1
CAS :SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].Formule :C24H26F3N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :457.49Eicosapentaenoic Acid
CAS :Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.Formule :C20H30O2Degré de pureté :96.20%Couleur et forme :LiquidMasse moléculaire :302.45Oncrasin-1
CAS :Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrationsFormule :C16H12ClNODegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :269.73(R)-BI-2852
CAS :(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Formule :C31H28N6O2Degré de pureté :97.78%Couleur et forme :SoildMasse moléculaire :516.59MLS-573151
CAS :MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Formule :C21H19N3O2SDegré de pureté :98.80%Couleur et forme :SolidMasse moléculaire :377.46Ref: TM-T22106
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€CASIN
CAS :CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).Formule :C20H22N2ODegré de pureté :100% - 99.86%Couleur et forme :SolidMasse moléculaire :306.4Ref: TM-T3971
1mg38,00€2mg49,00€5mg74,00€10mg120,00€25mg188,00€50mg283,00€100mg435,00€500mg938,00€1mL*10mM (DMSO)74,00€Sotorasib
CAS :Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C.Formule :C30H30F2N6O3Degré de pureté :98% - 99.89%Couleur et forme :SolidMasse moléculaire :560.59Ref: TM-T8684
1g1.359,00€1mg37,00€2mg52,00€5mg79,00€10mg126,00€25mg225,00€50mg374,00€100mg459,00€500mg1.026,00€1mL*10mM (DMSO)87,00€CID-1067700
CAS :CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13 nM).Formule :C18H18N2O4S2Degré de pureté :99.46%Couleur et forme :SolidMasse moléculaire :390.48Ref: TM-T7558
1mg35,00€2mg52,00€5mg74,00€10mg111,00€25mg188,00€50mg246,00€100mg319,00€1mL*10mM (DMSO)82,00€KRAS G12D modulator-1
CAS :KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and isFormule :C30H36FN5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :549.64RBC10
CAS :RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-Formule :C24H25ClN2O2Degré de pureté :98.38%Couleur et forme :SolidMasse moléculaire :408.92Ref: TM-T24706
1mg34,00€2mg52,00€5mg80,00€10mg116,00€25mg259,00€50mg374,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)86,00€Rac1-IN-3
CAS :Rac1-IN-3 (Compound 2) is a Rac1 inhibitor exhibiting an inhibitory concentration 50 (IC50) of 46.1 μM [1].Formule :C21H23N7O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :405.45Antineoplaston A10
CAS :Antineoplaston A10 (NSC-648539) is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.Formule :C13H14N2O3Degré de pureté :99.42%Couleur et forme :SolidMasse moléculaire :246.26Ref: TM-T7131
2mg47,00€5mg71,00€10mg108,00€25mg205,00€50mg311,00€100mg449,00€200mg628,00€1mL*10mM (DMSO)78,00€KRAS inhibitor-38
CAS :KRAS Inhibitor-38 (Example 18) is a potent inhibitor capable of effectively suppressing the activity of KRAS G12C, KRAS G12D, and KRAS G12V in vivo.Formule :C53H68ClF2N9O8SCouleur et forme :SolidMasse moléculaire :1064.68
