CFTR
Le CFTR est une protéine canal chlorure qui régule le transport des ions chlorure et bicarbonate à travers les membranes des cellules épithéliales, jouant un rôle crucial dans le maintien de l'équilibre hydrique dans les tissus. Les mutations du gène CFTR entraînent la mucoviscidose, une maladie génétique caractérisée par la production de mucus épais pouvant obstruer les voies respiratoires et causer de graves problèmes respiratoires et digestifs. Chez CymitQuimica, nous proposons une sélection de modulateurs CFTR pour soutenir vos recherches sur la mucoviscidose, le transport des ions et les troubles génétiques.
Produits appartenant à la catégorie "CFTR"
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UCCF-853
CAS :UCCF-853 是一种小分子 CFTR 调节剂,可用于研究囊性纤维化。Formule :C14H8ClF3N2ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :312.67CFTR corrector 16
CAS :CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.Formule :C27H26ClN5O2SCouleur et forme :SolidMasse moléculaire :520.05Lumacaftor
CAS :Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Formule :C24H18F2N2O5Degré de pureté :99.48% - 99.68%Couleur et forme :SolidMasse moléculaire :452.41PG01
CAS :PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Formule :C28H29N3O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :439.55Ref: TM-T16516
1mg84,00€5mg215,00€10mg324,00€25mg520,00€50mg702,00€100mg950,00€200mg1.283,00€1mL*10mM (DMSO)210,00€Nesolicaftor
CAS :Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Formule :C18H18N4O4Degré de pureté :98.64%Couleur et forme :SolidMasse moléculaire :354.36Ref: TM-T16681
1mg96,00€5mg215,00€10mg378,00€25mg650,00€50mg927,00€100mg1.254,00€1mL*10mM (DMSO)236,00€Crinecerfont tosylate
CAS :Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).Formule :C34H36ClFN2O4S2Couleur et forme :SolidMasse moléculaire :655.242CFTR corrector 8
CAS :CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.Formule :C29H27F2NO7Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :539.52Ref: TM-T63806
1mg52,00€5mg105,00€10mg164,00€25mg320,00€50mg504,00€100mg827,00€200mg1.111,00€1mL*10mM (DMSO)137,00€ARN23765
CAS :ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).Formule :C30H22F5N3O6Couleur et forme :SolidMasse moléculaire :615.504WAY-326766
CAS :WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).Formule :C21H23N3O5Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :397.42Ivacaftor
CAS :Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Formule :C24H28N2O3Degré de pureté :99% - 99.98%Couleur et forme :SolidMasse moléculaire :392.49Ref: TM-T2588
1mg38,00€5mg81,00€10mg127,00€25mg205,00€50mg304,00€100mg455,00€500mg998,00€1mL*10mM (DMSO)88,00€Tezacaftor
CAS :Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Formule :C26H27F3N2O6Degré de pureté :100% - 99.69%Couleur et forme :SolidMasse moléculaire :520.5Ref: TM-T2263
1mg40,00€2mg52,00€5mg82,00€10mg123,00€25mg212,00€50mg343,00€100mg505,00€1mL*10mM (DMSO)88,00€CFTR activator 2
CAS :CFTRactivator 2 (WAY-326769) acts as an activator for the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR).Formule :C27H27N3O3Couleur et forme :SolidMasse moléculaire :441.52KM11060
CAS :KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFormule :C19H17Cl2N3O2SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :422.33CFTR corrector 4
CAS :Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.Formule :C29H27F2NO7Degré de pureté :98.43%Couleur et forme :SolidMasse moléculaire :539.52Ref: TM-T10776
1mg74,00€5mg170,00€10mg264,00€25mg535,00€50mg753,00€100mg1.074,00€500mg2.147,00€1mL*10mM (DMSO)202,00€CFTR corrector 2
CAS :CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Formule :C27H23FN4O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :486.49Ref: TM-T5312
2mg39,00€5mg58,00€10mg85,00€25mg156,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)63,00€SRI-37240
CAS :SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.Formule :C24H23N3O2Degré de pureté :98.73%Couleur et forme :SolidMasse moléculaire :385.46Crofelemer
CAS :Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.Couleur et forme :SolidSRI-41315
CAS :SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.Formule :C22H19N3O2Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :357.41PPQ-102
CAS :PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Formule :C26H22N4O3Degré de pureté :99.17% - ≥95%Couleur et forme :SolidMasse moléculaire :438.48Ref: TM-T1874
1mg40,00€2mg51,00€5mg85,00€10mg135,00€25mg269,00€50mg520,00€100mg745,00€1mL*10mM (DMSO)93,00€DNDS
CAS :DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).Formule :C14H8N2Na2O10S2Degré de pureté :99.88%Couleur et forme :Physical Description White Powder (Ntp 1992)Masse moléculaire :474.33
