PDE
Les phosphodiestérases (PDE) sont des enzymes qui hydrolysent les nucléotides cycliques, tels que l'AMPc et le GMPc, en leurs formes inactives, jouant un rôle clé dans la régulation des voies de signalisation intracellulaire. Les inhibiteurs de PDE sont utilisés dans le traitement de diverses affections, notamment les maladies cardiovasculaires, la dysfonction érectile et les troubles respiratoires, en raison de leur capacité à moduler les niveaux de nucléotides cycliques. Chez CymitQuimica, nous proposons une gamme d'inhibiteurs de PDE pour soutenir vos recherches en signalisation cellulaire, pharmacologie et développement thérapeutique.
Produits appartenant à la catégorie "PDE"
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Olprinone
CAS :Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFormule :C14H10N4ODegré de pureté :99.68%Couleur et forme :SolidMasse moléculaire :250.26Dovramilast
CAS :Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Formule :C24H28N2O6SDegré de pureté :98.75% - 99.74%Couleur et forme :SolidMasse moléculaire :472.55Anagrelide
CAS :Anagrelide (Xagrid) is a Platelet-reducing Agent.Formule :C10H7Cl2N3ODegré de pureté :100%Couleur et forme :SolidMasse moléculaire :256.09Balipodect
CAS :Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Formule :C23H17FN6O2Degré de pureté :98.32% - 98.97%Couleur et forme :SolidMasse moléculaire :428.42Ref: TM-T1745
1mg38,00€2mg49,00€5mg79,00€10mg93,00€25mg156,00€50mg256,00€100mg444,00€1mL*10mM (DMSO)79,00€TPN171
CAS :TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonaryFormule :C24H35N5O3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :441.57PQ-10
CAS :PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.Formule :C22H21N5O3Degré de pureté :99.30%Couleur et forme :SolidMasse moléculaire :403.43Ref: TM-T24656
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg259,00€100mg374,00€200mg545,00€1mL*10mM (DMSO)57,00€Mirodenafil dihydrochloride
CAS :Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Formule :C26H39Cl2N5O5SDegré de pureté :99.64% - 99.78%Couleur et forme :SolidMasse moléculaire :604.59Bay 60-7550
CAS :Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.Formule :C27H32N4O4Degré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :476.57ENPP1 Inhibitor C
CAS :ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Formule :C15H18N6Couleur et forme :SolidMasse moléculaire :282.34Vardenafil dihydrochloride
CAS :Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Formule :C23H34Cl2N6O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :561.52Enoximone
CAS :Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Formule :C12H12N2O2SDegré de pureté :95.52%Couleur et forme :SolidMasse moléculaire :248.3KD-027
CAS :KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Formule :C25H35N7O6SDegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :561.65MY-5445
CAS :MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Formule :C20H14ClN3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :331.8BW-A 78U
CAS :BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Formule :C13H12FN5Degré de pureté :99.45%Couleur et forme :SolidMasse moléculaire :257.27Ref: TM-T5101
1mg39,00€5mg101,00€10mg153,00€25mg249,00€50mg359,00€100mg507,00€200mg695,00€1mL*10mM (DMSO)44,00€Piclamilast
CAS :Piclamilast (RP 73401) is a PDE4 inhibitor.Formule :C18H18Cl2N2O3Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :381.25Filaminast
CAS :Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Formule :C15H20N2O4Degré de pureté :98.44% - 99.64%Couleur et forme :SolidMasse moléculaire :292.33Ref: TM-T31792
1mg226,00€5mg552,00€10mg735,00€25mg1.111,00€50mg1.491,00€100mg2.005,00€200mg2.707,00€1mL*10mM (DMSO)500,00€Senazodan hydrochloride
CAS :Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Formule :C15H15ClN4ODegré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :302.76Ensifentrine
CAS :Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFormule :C26H31N5O4Degré de pureté :98.45% - 99.94%Couleur et forme :SolidMasse moléculaire :477.56Ref: TM-T25376
1mg35,00€5mg96,00€10mg160,00€25mg329,00€50mg533,00€100mg847,00€200mg1.159,00€1mL*10mM (DMSO)105,00€Lodenafil
CAS :Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Formule :C23H32N6O5SDegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :504.6Ref: TM-T7346
2mg35,00€5mg50,00€10mg81,00€25mg129,00€50mg187,00€100mg259,00€200mg373,00€1mL*10mM (DMSO)56,00€BAY 2666605
CAS :BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.Formule :C17H12F4N2O2Degré de pureté :99.98%Couleur et forme :SolidMasse moléculaire :352.28Ref: TM-T9805
1mg97,00€5mg235,00€10mg376,00€25mg828,00€50mg1.320,00€100mg2.118,00€1mL*10mM (DMSO)259,00€
