Anhydrase carbonique
L'anhydrase carbonique est une enzyme qui catalyse la conversion réversible du dioxyde de carbone et de l'eau en bicarbonate et protons. Cette enzyme joue un rôle crucial dans le maintien de l'équilibre acido-basique, la respiration et le transport du dioxyde de carbone dans le sang. Les inhibiteurs de l'anhydrase carbonique sont utilisés dans le traitement du glaucome, de l'épilepsie et du mal des montagnes, ainsi que dans la recherche sur l'homéostasie acido-basique et les échanges gazeux. Chez CymitQuimica, nous offrons une gamme d'inhibiteurs de l'anhydrase carbonique et de réactifs de haute qualité pour soutenir vos recherches en enzymologie, physiologie respiratoire et développement thérapeutique.
Produits appartenant à la catégorie "Anhydrase carbonique"
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Carbonic anhydrase inhibitor 15
Carbonic Anhydrase Inhibitor 15 (Compound 8), with an inhibitory constant (K_i) of 8.5 nM for hCA II, exhibits analgesic effects [1].Formule :C27H33N5O2S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :523.71SH7s
SH7s is an effective carbonic anhydrase inhibitor, exhibiting Ki values of 15.9 nM for hCA IX and 55.2 nM for hCA XII. Additionally, SH7s acts as a hypoxia-mediated chemosensitizer in colorectal cancer cells.Formule :C24H19ClF3N5O4SCouleur et forme :SolidMasse moléculaire :565.95Polmacoxib
CAS :Polmacoxib, a first-class NSAID, dual inhibitor of CA and COX-2, may hinder colorectal cancer growth in mice.Formule :C18H16FNO4SDegré de pureté :97.88%Couleur et forme :SolidMasse moléculaire :361.39Ref: TM-T21294
2mg47,00€5mg70,00€10mg107,00€25mg173,00€50mg259,00€100mg378,00€200mg563,00€1mL*10mM (DMSO)77,00€ALP/Carbonic anhydrase-IN-1
CAS :Compound 1e, also known as ALP/Carbonic anhydrase-IN-1, is a dual inhibitor targeting both carbonic anhydrase (CA) isozymes II, IX, and XII, as well as alkalineFormule :C15H16N2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :224.3CAIX/CAXII-IN-4
CAIX/CAXII-IN-4 (Compound 7h) is an inhibitor of carbonic anhydrase (CA) that binds to CAIX, CA XII, and CAII with Ki values of 1.324 μM, 0.435 μM, and 3.035 μM, respectively. This compound exhibits broad-spectrum anti-tumor activity and inhibits the proliferation of central nervous system tumor cells U251, with a GI50 of 0.361 μM.Formule :C23H21N5O3SCouleur et forme :SolidMasse moléculaire :447.51CAIX/CAXII-IN-3
CAIX/CAXII-IN-3 (compound 11) serves as an inhibitor for CAIX/CAXII, exhibiting an IC50 value of less than 65 nM. Additionally, this compound effectively inhibits the proliferation of human melanoma cells.Couleur et forme :Odour SolidWES-1
CAS :WES-1 (Compound 8g), a carbonic anhydrase IX inhibitor (Ki: 55.9 μM), exhibits broad-spectrum antiproliferative activity against various cancer cell lines,Formule :C20H20N4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :396.46Zonisamide
CAS :Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures.Formule :C8H8N2O3SDegré de pureté :99.05% - 99.9%Couleur et forme :Off-White PowderMasse moléculaire :212.23hCAII/XII-IN-1
hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Ki values of 8.4 nM and 9.4 nM, respectively. It plays a significant role in cancer research.Formule :C22H20N4O6S2Masse moléculaire :500.547Chlorothiazide
CAS :Chlorothiazide (Diuril) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.Formule :C7H6ClN3O4S2Degré de pureté :95.42%Couleur et forme :Crystals Physical Description Crystals; White Powder (Ntp 1992)Masse moléculaire :295.72hCAII-IN-9
CAS :hCAII-IN-9 inhibits hCA II/IX/XII with IC50s of 1.18, 0.17, 2.99 μM; not BBB permeable.Formule :C15H16ClN3O5S2Degré de pureté :98.63%Couleur et forme :SolidMasse moléculaire :417.89Carbonic anhydrase inhibitor 12
CAS :CA Inhibitor 12 strongly blocks CA II (K_i 1.72 nM), also inhibits CA I (271 nM), shows anticancer effects.Formule :C27H22BrN5O5S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :640.53CA Ⅱ-IN-1
CAⅡ-IN-1 (compound 2i) is an inhibitor of the CA Ⅱ isozyme, exhibiting an IC50 of 0.44 µM. This compound is utilized in metabolic research.Formule :C18H19NO6SCouleur et forme :SolidMasse moléculaire :377.41U-104
CAS :U-104 (NSC-213841) is an effective carbonic anhydrase (CA) inhibitor for CA IX( Ki=45.1 nM) and CA XII(Ki=4.5 nM).Formule :C13H12FN3O3SDegré de pureté :100% - 99.6%Couleur et forme :SolidMasse moléculaire :309.32Ref: TM-T2017
5mg35,00€10mg52,00€25mg87,00€50mg142,00€100mg250,00€200mg399,00€500mg652,00€1mL*10mM (DMSO)58,00€Dichlorphenamide
CAS :Dichlorphenamide (Diclofenamide) is a carbonic anhydrase inhibitor that is used in the treatment of glaucoma.Formule :C6H6Cl2N2O4S2Degré de pureté :96.87% - 98.51%Couleur et forme :Needles From Dimethylsulfoxide + Water SolidMasse moléculaire :305.16Ref: TM-T6469
5mg50,00€10mg65,00€25mg87,00€50mg96,00€100mg140,00€200mg202,00€500mg340,00€1mL*10mM (DMSO)59,00€CAIX Inhibitor S4
CAS :CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively.Formule :C15H17N3O4SDegré de pureté :98.35%Couleur et forme :SolidMasse moléculaire :335.38Ref: TM-T36758
2mg40,00€5mg60,00€10mg96,00€25mg188,00€50mg354,00€100mg528,00€500mg1.159,00€1mL*10mM (DMSO)66,00€EMAC10101d
CAS :compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with anFormule :C17H15Cl2N3O2S2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :428.36hCAI/II/IV-IN-28
CAS :hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity.Formule :C14H15N3O3SDegré de pureté :96.48%Couleur et forme :SolidMasse moléculaire :305.35Carbonic anhydrase inhibitor 26
Compound 6T, designated as Carbonic anhydrase inhibitor26, acts as an inhibitor of Carbonic Anhydrase II (Carbonic AnhydraseII), exhibiting an IC50 value of 9.10 ± 0.26 μM.Formule :C17H14N6O4Couleur et forme :SolidMasse moléculaire :366.33Perfluorohexane sulfonamide
CAS :Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.Formule :C6H2F13NO2SCouleur et forme :SolidMasse moléculaire :399.13
