Wnt/beta-caténine
Les inhibiteurs de la voie Wnt/beta-caténine sont des composés qui ciblent et inhibent la voie de signalisation Wnt/beta-caténine, essentielle pour la régulation du développement embryonnaire, de la prolifération cellulaire et du maintien des cellules souches. La dérégulation de cette voie est liée à divers cancers et maladies dégénératives. Les inhibiteurs de la signalisation Wnt/beta-caténine sont précieux pour la recherche visant à comprendre le rôle de cette voie dans les maladies et à développer des thérapies ciblées. Chez CymitQuimica, nous proposons des inhibiteurs de Wnt/beta-caténine pour soutenir vos recherches en biologie des cellules souches, biologie du développement et recherche sur le cancer.
Produits appartenant à la catégorie "Wnt/beta-caténine"
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Ipafricept
CAS :Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Couleur et forme :LiquidSKL2001
CAS :SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Formule :C14H14N4O3Degré de pureté :97.46% - 99.5%Couleur et forme :SolidMasse moléculaire :286.29Ref: TM-T6989
5mg40,00€10mg60,00€25mg107,00€50mg185,00€100mg339,00€200mg510,00€500mg797,00€1mL*10mM (DMSO)66,00€KY1220
CAS :KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.Formule :C14H10N4O3SDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :314.32Ref: TM-T15677
2mg46,00€5mg80,00€10mg117,00€25mg259,00€50mg374,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)73,00€NRX-252262
CAS :NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)Formule :C23H17Cl2F3N2O4SDegré de pureté :99.10% - 99.87%Couleur et forme :SolidMasse moléculaire :545.36Ref: TM-T9182
1mg114,00€5mg273,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)329,00€MSAB
CAS :MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.Formule :C15H15NO4SDegré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :305.35Ref: TM-T8710
1mg37,00€2mg49,00€5mg73,00€10mg119,00€25mg235,00€50mg354,00€100mg535,00€500mg1.121,00€1mL*10mM (DMSO)82,00€LP-922056
CAS :LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.Formule :C11H9ClN2O2S2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :300.78DK419
CAS :DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Formule :C16H8ClF6N3ODegré de pureté :98.15%Couleur et forme :SolidMasse moléculaire :407.7NRX-252114
CAS :NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).Formule :C22H12Cl2F3N3O2SDegré de pureté :98.26%Couleur et forme :SolidMasse moléculaire :510.32Dendrobium phenol
CAS :Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.Formule :C16H18O4Degré de pureté :98.66% - 99.48%Couleur et forme :SolidMasse moléculaire :274.31Ref: TM-TL0008
1mg49,00€2mg65,00€5mg97,00€10mg156,00€25mg255,00€50mg373,00€100mg555,00€1mL*10mM (DMSO)165,00€Pamidronic acid
CAS :Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem CellsFormule :C3H11NO7P2Degré de pureté :97.72%Couleur et forme :SolidMasse moléculaire :235.07Wnt pathway activator 2
CAS :Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Formule :C17H15NO4Degré de pureté :98.28%Couleur et forme :SolidMasse moléculaire :297.31Ref: TM-T13345
1mg49,00€5mg105,00€10mg169,00€25mg344,00€50mg562,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)116,00€JW74
CAS :JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Formule :C24H20N6O2SDegré de pureté :95.00%Couleur et forme :SolidMasse moléculaire :456.52BML-284
CAS :BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Formule :C19H18N4O3Degré de pureté :99.66% - 99.91%Couleur et forme :SolidMasse moléculaire :350.37Ref: TM-T3144
5mg60,00€10mg88,00€25mg140,00€50mg253,00€100mg427,00€200mg615,00€500mg938,00€1mL*10mM (DMSO)66,00€WAY-262611
CAS :WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.Formule :C20H22N4Degré de pureté :98.09% - 99.09%Couleur et forme :SolidMasse moléculaire :318.42Adavivint
CAS :Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.Formule :C29H24FN7ODegré de pureté :98.27% - 98.6%Couleur et forme :SolidMasse moléculaire :505.55CCT 031374 hydrobromide
CAS :CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Formule :C23H20BrN3ODegré de pureté :98.61%Couleur et forme :SolidMasse moléculaire :434.33Ref: TM-T21685
1mg38,00€5mg71,00€10mg105,00€25mg207,00€50mg329,00€100mg472,00€200mg620,00€1mL*10mM (DMSO)87,00€IWP-4
CAS :IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.Formule :C23H20N4O3S3Degré de pureté :100.00%Couleur et forme :SolidMasse moléculaire :496.62Cardiogenol C hydrochloride
CAS :Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).Formule :C13H17ClN4O2Degré de pureté :99.89% - 99.94%Couleur et forme :SolidMasse moléculaire :296.75TNIK-IN-7
CAS :TNIK-IN-7 is a Traf2 and Nck interacting kinase (TNIK) inhibitor with antitumor activity for the study of signaling and proliferation in colorectal cancer cellsFormule :C23H22N4O2Degré de pureté :99.87%Couleur et forme :SoildMasse moléculaire :386.45Tankyrase-IN-2
CAS :Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectivelyFormule :C17H14F2N2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :316.3BML-286
CAS :BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.Formule :C22H18N2O4Couleur et forme :SolidMasse moléculaire :374.39Carboxylesterase-IN-2
CAS :Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.Formule :C13H12N4OSDegré de pureté :100%Couleur et forme :SoildMasse moléculaire :272.33Ref: TM-T77524
1mg62,00€5mg140,00€10mg215,00€25mg369,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)156,00€IWP-O1
CAS :IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formule :C26H20N6ODegré de pureté :99.12%Couleur et forme :SolidMasse moléculaire :432.48Ref: TM-T5342
2mg39,00€5mg64,00€10mg101,00€25mg163,00€50mg226,00€100mg320,00€200mg459,00€1mL*10mM (DMSO)70,00€Wnt pathway inhibitor 3
CAS :Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studiesFormule :C21H17BrN2O5Degré de pureté :99.69%Couleur et forme :SoildMasse moléculaire :457.27NRX-103095
CAS :NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.Formule :C22H16Cl2F3N3O3SDegré de pureté :99.16% - 99.60%Couleur et forme :SolidMasse moléculaire :530.35Ref: TM-T63730
1mg150,00€5mg364,00€10mg588,00€25mg1.169,00€50mg1.882,00€100mg2.822,00€1mL*10mM (DMSO)426,00€KY-05009
CAS :KY-05009 blocks TGF-β1 EMT in lung cancer cells, inhibits TNIK, Wnt genes, induces apoptosis, and is an ATP-competitive TNIK inhibitor (Ki = 100 nM).Formule :C18H16N4O2SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :352.41Ref: TM-T11793
5mg50,00€10mg71,00€25mg117,00€50mg170,00€100mg245,00€200mg354,00€1mL*10mM (DMSO)51,00€CCT251545
CAS :CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Formule :C23H24ClN5ODegré de pureté :98.2% - 98.69%Couleur et forme :SolidMasse moléculaire :421.92β-catenin modulator IIa-661
CAS :β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Formule :C19H23ClN2O3SDegré de pureté :99.53%Couleur et forme :SoildMasse moléculaire :394.92ETC-159
CAS :ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.Formule :C19H17N7O3Degré de pureté :96.87% - 99.30%Couleur et forme :SolidMasse moléculaire :391.38Wnt pathway activator 1
CAS :Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.Formule :C18H16O4Degré de pureté :99.94%Couleur et forme :SolidMasse moléculaire :296.32Ref: TM-T17256
2mg34,00€5mg52,00€10mg80,00€25mg131,00€50mg212,00€100mg316,00€200mg454,00€1mL*10mM (DMSO)52,00€Blosozumab
CAS :Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Degré de pureté :>95% - >95%Couleur et forme :Liquid
