Cellules souches
Les inhibiteurs de cellules souches sont des composés qui ciblent spécifiquement les cellules souches et leurs voies de signalisation, affectant leur capacité à s'auto-renouveler et à se différencier. Ces inhibiteurs sont essentiels dans la recherche axée sur le contrôle du comportement des cellules souches, la compréhension des processus de développement et le développement de thérapies pour des maladies comme le cancer, où les cellules souches sont censées jouer un rôle clé. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de cellules souches pour soutenir vos recherches en médecine régénérative, biologie du développement et oncologie.
Produits appartenant à la catégorie "Cellules souches"
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BP-1-102
CAS :BP-1-102 is an orally active, effective and specific STAT3 inhibitor.Formule :C29H27F5N2O6SDegré de pureté :99.25% - 99.81%Couleur et forme :SolidMasse moléculaire :626.59Ref: TM-T3708
1mg39,00€2mg51,00€5mg84,00€10mg119,00€25mg210,00€50mg354,00€100mg522,00€1mL*10mM (DMSO)104,00€IMR-1
CAS :IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formule :C15H15NO5S2Degré de pureté :97.96% - 98.38%Couleur et forme :SolidMasse moléculaire :353.41CHIR-99021 HCl
CAS :CHIR-99021 HCl is a selective GSK-3α/β inhibitor (IC50: 10/6.7 nM), 500x selective over other kinases, boosts Wnt pathway, and enhances stem cell renewal.Formule :C22H19Cl3N8Degré de pureté :98.07% - 98.44%Couleur et forme :SolidMasse moléculaire :501.8Ref: TM-T2310L
1mg35,00€2mg52,00€5mg77,00€10mg96,00€25mg163,00€50mg240,00€100mg465,00€200mg675,00€500mg1.026,00€1mL*10mM (DMSO)86,00€BIP-135
CAS :BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.Formule :C21H13BrN2O3Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :421.24Ref: TM-T14613
1mg34,00€5mg80,00€10mg116,00€25mg221,00€50mg329,00€100mg472,00€200mg652,00€1mL*10mM (DMSO)86,00€JAK-IN-28
CAS :JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formule :C20H18ClN7ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.86ABBV-712
CAS :ABBV-712 is a selective Tyrosine Kinase 2 (TYK2) inhibitor, demonstrating an IC50 value of 0.195 μM, and is implicated in the regulation of autoimmune diseasesFormule :C24H28N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :452.5NT219
CAS :NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formule :C16H14BrNO5SDegré de pureté :98.06% - 99.72%Couleur et forme :SolidMasse moléculaire :412.26ROCK2-IN-2
CAS :ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Formule :C18H12N6OSDegré de pureté :98.45%Couleur et forme :SolidMasse moléculaire :360.39Ref: TM-T12747
1mg52,00€5mg117,00€10mg187,00€25mg320,00€50mg472,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)143,00€ROCK-IN-7
CAS :ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Formule :C17H17N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :327.4(Rac)-SIS3 free base
CAS :SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formule :C28H27N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :453.53YAP/TAZ inhibitor-2
CAS :Potent oral TEAD-YAP/TAZ inhibitor-2 with 3 nM EC50; exhibits anti-proliferative and antitumor effects.Formule :C19H14F4N4ODegré de pureté :98.84%Couleur et forme :SoildMasse moléculaire :390.33Ref: TM-T60218
1mg92,00€2mg119,00€5mg187,00€10mg298,00€25mg502,00€50mg725,00€100mg1.017,00€500mg2.023,00€1mL*10mM (DMSO)207,00€IWR-1
CAS :IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Formule :C25H19N3O3Degré de pureté :98.46% - 99.82%Couleur et forme :SolidMasse moléculaire :409.44IWP 12
CAS :IWP 12 is a potent inhibitor of porcupine (Porcn), blocking Wnt signaling and inhibiting fin regeneration in adult and juvenile fish.Formule :C18H18N4O2S3Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :418.56JBJ-02-112-05
CAS :JBJ-02-112-05 is a potent, mutant-selective, allosteric and orally active inhibitor of EGFR with an IC 50 of 15 nM for EGFR L858R/T790M [1].Formule :C27H20N4O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :464.54Netarsudil Dihydrochloride
CAS :Netarsudil Dihydrochloride (AR-13324 Dihydrochloride) is an inhibitor of Rho-related protein kinase (ROCK) and norepinephrine transporter (NET) and is effective in reducing intraocular pressure (IOP).Cost-effective and quality-assured.Formule :C28H29Cl2N3O3Degré de pureté :99.94% - 99.98%Couleur et forme :SolidMasse moléculaire :526.45Bikinin
CAS :Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.Formule :C9H9BrN2O3Degré de pureté :100% - 99.86%Couleur et forme :SolidMasse moléculaire :273.08Ref: TM-T1965
10mg47,00€25mg77,00€50mg119,00€100mg187,00€200mg279,00€500mg472,00€1mL*10mM (DMSO)34,00€Kartogenin
CAS :Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.Formule :C20H15NO3Degré de pureté :96.25% - 97.79%Couleur et forme :SolidMasse moléculaire :317.34MRT-10
CAS :MRT-10 is a Smoothened (Smo) receptor antagonist.Formule :C24H23N3O5SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :465.52Ref: TM-T23027
1mg47,00€2mg63,00€5mg96,00€10mg135,00€25mg265,00€50mg378,00€100mg530,00€200mg720,00€1mL*10mM (DMSO)87,00€GDC-9918
CAS :GDC-9918 (compound GDC-9918) is an inhibitor of Janus kinases.Formule :C20H18F2N6O5SCouleur et forme :SolidMasse moléculaire :492.46JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Couleur et forme :Odour SolidFM-381
CAS :FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Formule :C24H24N6O2Degré de pureté :98.44%Couleur et forme :SolidMasse moléculaire :428.49MNK8
CAS :MNK8 is a potent STAT3 inhibitor, impairs DNA binding, and inhibits liver cancer cell growth.Formule :C15H12N2O2Degré de pureté :99.74%Couleur et forme :SolidMasse moléculaire :252.27JAK1-IN-8
CAS :JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).Formule :C22H23FN4O3SDegré de pureté :98.36%Couleur et forme :SolidMasse moléculaire :442.51Ref: TM-T35899
5mg47,00€10mg79,00€25mg144,00€50mg250,00€100mg424,00€200mg568,00€1mL*10mM (DMSO)50,00€Jervine
CAS :Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.Formule :C27H39NO3Degré de pureté :99.20% - 99.86%Couleur et forme :Needles From Methanol + Water SolidMasse moléculaire :425.6Ref: TM-T3363
5mg70,00€10mg119,00€25mg259,00€50mg499,00€100mg715,00€500mg1.444,00€1mL*10mM (DMSO)74,00€CJJ300
CAS :CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.Formule :C30H33N3Degré de pureté :99.41%Couleur et forme :SolidMasse moléculaire :435.6Ref: TM-T62483
2mg35,00€5mg51,00€10mg90,00€25mg164,00€50mg259,00€100mg393,00€200mg552,00€1mL*10mM (DMSO)57,00€S-Ruxolitinib
CAS :S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.Formule :C17H18N6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :306.37BDP9066
CAS :BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.Formule :C20H24N6Degré de pureté :98.18%Couleur et forme :SolidMasse moléculaire :348.44Ref: TM-T14521
1mg57,00€5mg120,00€10mg188,00€25mg432,00€50mg747,00€100mg1.293,00€500mg2.585,00€1mL*10mM (DMSO)133,00€GNF-6231
CAS :GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.Formule :C24H25FN6O2Degré de pureté :100% - 99.54%Couleur et forme :SolidMasse moléculaire :448.49WDR5-0103 hydrochloride[890190-22-4(free base)]
WDR5-0103 hydrochloride[890190-22-4(free base)] (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd:Formule :C21H26ClN3O4Degré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :419.9Londamocitinib
CAS :Londamocitinib (JAK1-IN-7) is a selective and potent JAK1 inhibitor with anti-inflammatory activity.Formule :C28H31F2N7O4SDegré de pureté :99.47%Couleur et forme :SolidMasse moléculaire :599.65Ref: TM-T11706
1mg180,00€5mg439,00€10mg597,00€25mg905,00€50mg1.169,00€100mg1.568,00€1mL*10mM (DMSO)567,00€NRX-103094
CAS :NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.Formule :C20H11Cl2F3N2O4SDegré de pureté :99.50%Couleur et forme :SolidMasse moléculaire :503.28JI051
CAS :JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Formule :C22H24N2O3Degré de pureté :≥98% - ≥98.0%Couleur et forme :SolidMasse moléculaire :364.44AZD8542
CAS :AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formule :C25H24N4O2Degré de pureté :99.96%Couleur et forme :SolidMasse moléculaire :412.48Tyk2-IN-22
CAS :Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formule :C16H16ClN5O2Couleur et forme :SolidMasse moléculaire :345.78NIBR-LTSi
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.Formule :C18H20N4ODegré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :308.38JAK-STAT-IN-1
CAS :JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formule :C21H21N5O2Degré de pureté :99.21%Couleur et forme :SolidMasse moléculaire :375.42SB-747651A Dihydrochloride
CAS :SB-747651A dihydrochloride, an MSK1 inhibitor (IC50=11 nM), also targets PRK2, RSK1, p70S6K, ROCK-II; potential in inflammation study.Formule :C16H24Cl2N8ODegré de pureté :97.02%Couleur et forme :SolidMasse moléculaire :415.32Ref: TM-T9652
1mg73,00€5mg155,00€10mg220,00€25mg369,00€50mg525,00€100mg712,00€500mgÀ demander1mL*10mM (DMSO)169,00€MSC-1254
MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.Formule :C25H22F2N4O4SCouleur et forme :SolidMasse moléculaire :512.53IHMT-MST1-58
CAS :IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.Formule :C21H22N6O3SDegré de pureté :98% - 98.48%Couleur et forme :SolidMasse moléculaire :438.5STAT3-IN-20
CAS :STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclearFormule :C30H27F4N7SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :593.64BIO-013077-01
CAS :BIO-013077-01 is a potent TGFbeta family type I receptors antagonist.Formule :C17H13N5Degré de pureté :99.87%Couleur et forme :SolidMasse moléculaire :287.32Ref: TM-T8330
1mg50,00€5mg92,00€10mg140,00€25mg273,00€50mg393,00€100mg557,00€200mg753,00€1mL*10mM (DMSO)138,00€CK2-IN-4
CAS :CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM.Formule :C18H11N3O4SDegré de pureté :99.72%Couleur et forme :SolidMasse moléculaire :365.36Ponsegromab
CAS :Ponsegromab (PF 06946860), a humanized anti-GDF15 antibody, may treat cancer cachexia by blocking GDF15/GFRAL signaling.Degré de pureté :100% (SEC-HPLC) - > 95%Couleur et forme :LiquidMasse moléculaire :146.08 kDaFz7-21
CAS :Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.Formule :C83H114N18O23S2Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :1796.03STAT3 degrader-2
CAS :STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and variousFormule :C59H62N9O13PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1136.15CIA-1 (Free base)
CAS :CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formule :C17H19N3O2SDegré de pureté :99%Couleur et forme :SolidMasse moléculaire :329.42Abrocitinib
CAS :Abrocitinib (PF-04965842) (PF-04965842) is a potent, specific and orally-active JAK1 inhibitor (IC50s: 29/803 nM for JAK1/2).Formule :C14H21N5O2SDegré de pureté :99.09% - 99.91%Couleur et forme :SolidMasse moléculaire :323.41Ref: TM-TQ0037
1mg85,00€2mg107,00€5mg167,00€10mg284,00€25mg467,00€50mg692,00€100mg938,00€1mL*10mM (DMSO)188,00€JAK/HDAC-IN-4
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.Formule :C30H32N8O5SCouleur et forme :SolidMasse moléculaire :616.69Gossypolone
CAS :Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.Formule :C30H26O10Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :546.52M3686
CAS :M3686 (Compound 29) is a potent and selective TEAD1 inhibitor with an IC50 value of 51 nM. It exhibits weaker binding activity toward TEAD3. M3686 significantly inhibits the cellular activity of YAP-dependent NCI-H226 cell lines, with an IC50 value of 0.06 μM, and demonstrates strong antitumor effects in the NCI-H226 xenograft model.Formule :C21H18F3N5O2Couleur et forme :SolidMasse moléculaire :429.395
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