IGF-1R
Les inhibiteurs d'IGF-1R sont des composés qui ciblent spécifiquement le récepteur du facteur de croissance analogue à l'insuline 1 (IGF-1R), une tyrosine kinase réceptrice impliquée dans la croissance, le développement et la survie cellulaires. La signalisation IGF-1R joue un rôle important dans la progression du cancer, ce qui rend ces inhibiteurs précieux pour la recherche en oncologie. Chez CymitQuimica, nous proposons des inhibiteurs d'IGF-1R pour soutenir vos recherches en biologie du cancer, endocrinologie et développement de thérapies ciblées.
Produits appartenant à la catégorie "IGF-1R"
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GSK1838705A
CAS :GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formule :C27H29FN8O3Degré de pureté :100% - 99.63%Couleur et forme :SolidMasse moléculaire :532.57MSDC 0160
CAS :MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.Formule :C19H18N2O4SDegré de pureté :99.45% - 99.53%Couleur et forme :SolidMasse moléculaire :370.42Ref: TM-T2607
1mg35,00€2mg50,00€5mg77,00€10mg99,00€25mg154,00€50mg197,00€100mg350,00€1mL*10mM (DMSO)82,00€Ginsenoside Rg5
CAS :Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.Formule :C42H70O12Degré de pureté :98% - 98.07%Couleur et forme :SolidMasse moléculaire :767Ref: TM-T6S1487
1mg113,00€5mg265,00€10mg426,00€25mg702,00€50mg938,00€100mg1.320,00€1mL*10mM (DMSO)360,00€IGF1R/CD221 Protein, Mouse, Recombinant (His)
IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Couleur et forme :Lyophilized PowderMasse moléculaire :105.2 kDa (predicted); 172.5 kDa, 117.1 kDa and 49.8 kDa, corresponding to the single chain, α subunit and β subunit respectively (reducing condition, due to glycosylation)Tyrphostin AG 538
CAS :Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.Formule :C16H11NO5Degré de pureté :99.73%Couleur et forme :SoildMasse moléculaire :297.26AG1024
CAS :AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).Formule :C14H13BrN2ODegré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :305.17AZ7550
CAS :AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formule :C27H31N7O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :485.58WAY-270250
CAS :WAY-270250 is an IGF-1R/SRC inhibitor.Formule :C18H16N2O2Degré de pureté :99.77%Couleur et forme :SoildMasse moléculaire :292.33XL228
CAS :XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formule :C22H31N9ODegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :437.54Ref: TM-T17267
1mg56,00€2mg78,00€5mg99,00€10mg149,00€25mg258,00€50mg393,00€100mg582,00€1mL*10mM (DMSO)110,00€PQ401
CAS :PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formule :C18H16ClN3O2Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :341.79PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Formule :C18H17Cl2N3O2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :378.25Ref: TM-T4324
2mg35,00€5mg48,00€10mg63,00€25mg99,00€50mg172,00€100mg286,00€200mg418,00€1mL*10mM (DMSO)63,00€BMS-754807
CAS :BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.Formule :C23H24FN9ODegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :461.49Ref: TM-T2349
1mg49,00€2mg70,00€5mg96,00€10mg166,00€25mg328,00€50mg537,00€100mg772,00€1mL*10mM (DMSO)116,00€AZD-3463
CAS :AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formule :C24H25ClN6ODegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :448.95AZ7550 hydrochloride
CAS :AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formule :C27H32ClN7O2Degré de pureté :97.07%Couleur et forme :SolidMasse moléculaire :522.04NVP-AEW541
CAS :NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-basedFormule :C27H29N5ODegré de pureté :96.03% - 99.55%Couleur et forme :SolidMasse moléculaire :439.55MAZ51
CAS :MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.Formule :C21H18N2ODegré de pureté :98.53%Couleur et forme :SolidMasse moléculaire :314.38IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisCouleur et forme :Lyophilized PowderMasse moléculaire :105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.MID-1
CAS :MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Formule :C12H11N3O4SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :293.3Ref: TM-T8773
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)109,00€IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisCouleur et forme :Lyophilized PowderMasse moléculaire :80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.Indirubin Derivative E804
CAS :Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Formule :C20H19N3O4Degré de pureté :98.75%Couleur et forme :SolidMasse moléculaire :365.38Ref: TM-T11654
1mg44,00€5mg93,00€10mg131,00€25mg207,00€50mg309,00€100mg459,00€200mg657,00€1mL*10mM (DMSO)93,00€
