IGF-1R
Les inhibiteurs d'IGF-1R sont des composés qui ciblent spécifiquement le récepteur du facteur de croissance analogue à l'insuline 1 (IGF-1R), une tyrosine kinase réceptrice impliquée dans la croissance, le développement et la survie cellulaires. La signalisation IGF-1R joue un rôle important dans la progression du cancer, ce qui rend ces inhibiteurs précieux pour la recherche en oncologie. Chez CymitQuimica, nous proposons des inhibiteurs d'IGF-1R pour soutenir vos recherches en biologie du cancer, endocrinologie et développement de thérapies ciblées.
Produits appartenant à la catégorie "IGF-1R"
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GSK1904529A
CAS :GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .Formule :C44H47F2N9O5SDegré de pureté :98.07% - 99%Couleur et forme :SolidMasse moléculaire :851.96BMS-536924
CAS :BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity forFormule :C25H26ClN5O3Degré de pureté :99.02%Couleur et forme :SolidMasse moléculaire :479.96AZ7550 trimesylate salt
CAS :AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 inhibits IGF1R activity and can be used in the study of lung cancer.Formule :C30H43N7O11S3Degré de pureté :99.24%Couleur et forme :SolidMasse moléculaire :773.9IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisCouleur et forme :Lyophilized PowderMasse moléculaire :105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.NT157
CAS :NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.Formule :C16H14BrNO5SDegré de pureté :97.55%Couleur et forme :SolidMasse moléculaire :412.26I-OMe-Tyrphostin AG 538
CAS :I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.Formule :C17H12INO5Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :437.19Ref: TM-T11593
1mg56,00€5mg119,00€10mg187,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)131,00€cis-NVP-ADW742
CAS :NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Formule :C28H31N5OCouleur et forme :SolidMasse moléculaire :453.59Linsitinib
CAS :OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.Formule :C26H23N5ODegré de pureté :98.98% - ≥95%Couleur et forme :SolidMasse moléculaire :421.49NVP-TAE 226
CAS :NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Formule :C23H25ClN6O3Degré de pureté :98.07% - 98.78%Couleur et forme :SolidMasse moléculaire :468.94Ref: TM-T1918
1mg48,00€2mg63,00€5mg101,00€10mg163,00€25mg264,00€50mg378,00€100mg567,00€1mL*10mM (DMSO)101,00€AGL-2263
CAS :AGL-2263 is a blocker of insulin receptor (IR)Formule :C17H10N2O5Couleur et forme :SolidMasse moléculaire :322.27Protonstatin-1
CAS :Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.Formule :C8H5NO2S2Degré de pureté :99.77%Couleur et forme :SolidMasse moléculaire :211.26Ref: TM-T71812
1mg96,00€5mg227,00€10mg329,00€25mg567,00€50mg753,00€100mg1.035,00€200mg1.406,00€1mL*10mM (DMSO)250,00€Picropodophyllin
CAS :Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.Formule :C22H22O8Degré de pureté :98.88% - 99.55%Couleur et forme :SolidMasse moléculaire :414.41Ref: TM-T6943
5mg64,00€10mg88,00€25mg170,00€50mg316,00€100mg535,00€500mg1.121,00€1mL*10mM (DMSO)69,00€KW-2450 free base
CAS :KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.Formule :C28H29N5O3SDegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :515.63Ceritinib
CAS :Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Formule :C28H36ClN5O3SDegré de pureté :100% - 99.77%Couleur et forme :SolidMasse moléculaire :558.14CL-A3-7
CAS :CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.Formule :C24H22Br2F2N2O3Couleur et forme :SolidMasse moléculaire :584.25ALK inhibitor 1
CAS :ALK inhibitor 1 is a selective ALK kinase inhibitor.Formule :C23H28BrN7O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :562.48Ref: TM-T10285
1mg52,00€5mg116,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)143,00€Insulin(cattle)
CAS :Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.Formule :C254H377N65O75S6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :5733.49NBI-31772
CAS :NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).Formule :C17H11NO7Degré de pureté :99.83%Couleur et forme :SolidMasse moléculaire :341.27HNMPA
CAS :HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.Formule :C11H11O4PDegré de pureté :99.11%Couleur et forme :SolidMasse moléculaire :238.18Ref: TM-T21761
1mg50,00€2mg65,00€5mg93,00€10mg144,00€25mg301,00€50mg452,00€100mg660,00€500mg1.396,00€1mL*10mM (DMSO)106,00€NVP-ADW742
CAS :NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-AblFormule :C28H31N5ODegré de pureté :99.22% - 99.79%Couleur et forme :SolidMasse moléculaire :453.58
